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mariaermolaeva.bsky.social
Group Leader @Leibniz Institute on Aging. Discovering novel and unconventional interventions for healthy aging. Interested in metabolism, stress responses and microbiome.
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New fundamental discovery: study suggests that cellular compartments likely have “specialized ribosomes” with unconventional protein compositions that have higher "preference" for mRNAs that are most relevant for a given compartment. www.science.org/doi/10.1126/...

submitted 1 day ago • 0 comments

🚨G-JAM2025 Registration Alert!🚨 Join us in September for an exciting #aging research meeting co-organized by FLI Jena and ERIBA Groningen! We're bringing together top experts to explore aging from mechanistic insights in model organisms to human aging and interventions 1/4

submitted 5 days ago • 1 comment

Human clinical trial shows that semaglutide reduces cigarette smoking and alcohol consumption. It really turns into a drug to treat almost anything.. jamanetwork.com/journals/jam...

submitted 21 days ago • 1 comment

It’s so nice to be able to celebrate something this week. Newest work from the group! How are nuclear contents delivered to the cytosolic autophagy machinery while maintaining nuclear integrity? Nuclear envelope gymnastics! Cool role for Dnm1/Drp1. www.nature.com/articles/s41...

submitted 31 days ago • 3 comments

I'm often asked if I would take an anti-aging drug 💊 discovered in my lab. As of today, the answer is yes! I'm starting a new compound we identified last year, based on insights from the gut microbiome of human centenarians + many tests and screens in worms and human cells (1/2)

submitted 30 days ago • 1 comment

ProtGPS, a protein language model, cracked cellular localization code of human proteins, predicting their destination and finding pathogenic mutations that disrupt localization. Kudos to scores of wet lab biologists whose real-world data made this possible www.science.org/doi/10.1126/...

submitted 31 days ago • 0 comments

More mixed press about intermittent fasting (IF): short-term IF improves glucose tolerance in adult mice, but long-term IF impairs pancreatic beta cell maturation in younger mice with effects comparable to type I diabetes. www.cell.com/cell-reports...

submitted 49 days ago • 0 comments

A healthy diet that kills your hair: intermittent fasting inhibits hair follicle regeneration by disrupting normal metabolism of activated hair follicle stem cells, leading to their selective death through apoptosis. www.cell.com/cell/abstrac...

submitted 50 days ago • 0 comments

Human study suggests that epigenetic aging is driven by somatic mutations. www.nature.com/articles/s43...

submitted 54 days ago • 0 comments

Are tattoos potential inducers of chronic inflammation? Preprint shows that tattoo ink is taken up by macrophages and triggers an inflammatory response that is detectable months later. www.biorxiv.org/content/10.1...

submitted 64 days ago • 0 comments

Pre-new year news feed is full of 2024 resolutions and health and lifestyle advices for 2025. My favourite one: chew gum because (quote) "chewing gum increases the flow of blood to the head/brain". Is this even true?

submitted 70 days ago • 0 comments

Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system. www.nature.com/articles/s43...

submitted 71 days ago • 1 comment

It was great pleasure to speak with Ainur Mukhanbetzhanova about our work on developing molecular mimetics of healthy lifestyle, and especially our recent successful efforts in discovering molecular #mimetics of restorative #sleep youtu.be/T0d0WYbAUxE?...

submitted 74 days ago • 2 comments

✨✨The 2025 Keystone Symposium on Aging and Gerotherapeutics is coming up and early bird registration ends today! Very excited about our speaker lineup. Check it out! www.keystonesymposia.org/conferences/...

submitted 76 days ago • 0 comments

Study shows that neuronal and synaptic excitation are coupled to mitochondria via Ca2+ signaling. This coupling provides energy for memory formation and gets disrupted during aging contributing to cognitive decline. www.science.org/doi/10.1126/...

submitted 77 days ago • 0 comments

2 parallel studies suggest that a bile acid metabolite mediates the anti-aging effects of caloric restriction (CR) by activating sirtuins and AMPK. While healthspan data and the mechanism are impressive, the link to CR appears stretched. www.nature.com/articles/d41...

submitted 79 days ago • 0 comments

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

submitted 81 days ago • 22 comments

Updated Aging Starter Packs to find people and labs who work on aging!! Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ Let me know if you'd like to be added! 😀

submitted 85 days ago • 23 comments

Can one become too old for healthy aging? In our recent review, we explore possible age limitations of the current longevity treatments. www.nature.com/articles/s44...

submitted 88 days ago • 7 comments

🚨🚨Mark your calendars for G-JAM2025 meeting organised be me and Sandro Cellerino. We will discuss human aging, longevity interventions, molecular and systems aging, comparative biology of aging, sex-specific aspects of aging and more. Looking forward! www.leibniz-fli.de/news-events/...

submitted 92 days ago • 0 comments

New to bluesky and looking to re-connect with aging and longevity research community members who transitioned to bsky.

submitted 92 days ago • 0 comments