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markdhumphries.bsky.social
Theoretical systems neuroscientist. Author of “The Spike: An Epic Journey Through the Brain in 2.1 Seconds”: https://tinyurl.com/ymwy9jrh Lab: https://humphries-lab.org Essays on the brain: https://drmdhumphries.medium.com/
43 posts 3,032 followers 222 following
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Terrific example of psychology done rigorously! Well done all; and great to see the outcome of all those people toing and froing outside my office under Dani Ropar’s watchful eye…

Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).

🧠What do random neural networks have in common with the motor cortex? Turns out, a lot! Both exhibit similar low‑dimensional dynamics across sensorimotor tasks.👇🧵

"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."

Because we must build good things while we scream about the bad, I have started a "Data for Good" team @data-for-good-team.bsky.social that partners with organizations needing short-term data science help. We have three projects ongoing & will add more as our capacity grows. data-for-good-team.org

Just look what was waiting for me when I came back from my run. Elusive Cures is now a REAL BOOK!! press.princeton.edu/books/hardco...

Registration is open for UK Neural Computation 2025 10th/11th July! We are offering 8 conference fellowships to support attendance. ***Abstract submission deadline is 12th May!*** neuralcomputation.uk/submission.h... Register here: neuralcomputation.uk/registration... Any q's - get in touch!

Basal ganglia output is a formidable bottleneck Striatum neurons project to output nuclei in a ratio ~16:1; but their targets outnumber them by up to 150 to 1. New paper from me, on how I got to those numbers & the model of basal ganglia output they imply www.eneuro.org/content/12/4...

📢 We have an opportunity for students to join our PhD programme in Theoretical Neuroscience and Machine Learning this September. Application deadline is 27 May 2025. Information & how to apply: www.ucl.ac.uk/gatsby/study-and-work/gatsby-unit-phd-programme

We are super happy to announce the third Workshop of Ideas in Neuroscience! We will once again look critically at assumptions of modern neuroscience: what does it mean that the brain encodes information? Is this a useful approach, or a metaphor that blurs our vision?

Basal ganglia output is a formidable bottleneck Striatum neurons project to output nuclei in a ratio ~16:1; but their targets outnumber them by up to 150 to 1. New paper from me, on how I got to those numbers & the model of basal ganglia output they imply www.eneuro.org/content/12/4...

Conference Fellowships for the UK Neural Computation meeting are now available, to support presenting authors; sponsored by @aria-research.bsky.social Includes fee waiver and attendance expenses Apply here by May 23rd neuralcomputation.uk/fellowships.... p.s. UKNC abstracts due by May 12th!

Useful idea here to talk of “converging evidence” rather than “scientific consensus” Not least because some read “consensus” as a conspiracy to silence alternative voices We’ve other names for similar ideas - Edward Wilson’s “consilience”, “triangulation” - but none so transparent

Registration open for UK Neural Computation 2025 @Imperial neuralcomputation.uk/registration... ECR day: 9 July, ~30 free places Main meeting: 10-11 July Pls share! Sponsors @aria-research.bsky.social @crick.ac.uk Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/

The preliminary program for the 2026 Basal Ganglia Gordon Research Conference is up! www.grc.org/basal-gangli... Super excited about this program and to move the meeting to Europe for the first time - come join us in Tuscany!

Registration open for UK Neural Computation 2025 @Imperial neuralcomputation.uk/registration... ECR day: 9 July, ~30 free places Main meeting: 10-11 July Pls share! Sponsors @aria-research.bsky.social @crick.ac.uk Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social & me

My lab is hiring a pre-doctoral research assistant to work on the neural computations of foraging, seeking common cross-species algorithms. A BBSRC-funded project in collaboration with Matt Apps (Birmingham) & Nathan Lepora (Bristol) Closes May 5th Pls share! jobs.nottingham.ac.uk/vacancy.aspx...

My lab is hiring a pre-doctoral research assistant to work on the neural computations of foraging, seeking common cross-species algorithms. A BBSRC-funded project in collaboration with Matt Apps (Birmingham) & Nathan Lepora (Bristol) Closes May 5th Pls share! jobs.nottingham.ac.uk/vacancy.aspx...

Cognitive scientists who work across levels of analysis should be called Marr's Rovers

Averaging over time hides what a neuron actually sees, what it actually gets to compute with, writes @markdhumphries.bsky.social. #neuroskyence www.thetransmitter.org/neural-codin...

🚨New lab preprint alert!🚨 Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision. (Link at the end of the thread) 1/9

1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!

Neuroscience faces a unique problem: It is the only field of research in which the researcher’s understanding is generated by the very thing it is trying to understand, writes @markdhumphries.bsky.social in his latest column for The Transmitter. www.thetransmitter.org/systems-neur...

"Let’s play the optimist: Perhaps human ingenuity will find a way around the limits to obtaining all knowledge of the brain. Then all we have to do is understand that knowledge, writes @markdhumphries.bsky.social in his latest column for The Transmitter. www.thetransmitter.org/systems-neur...

Latest column from me in @thetransmitter.bsky.social: on the limits of what we can know about the brain Enjoy! www.thetransmitter.org/systems-neur...

Abstract submission is open for UK Neural Computation 2025 @ Imperial College (9-11 July) neuralcomputation.uk/submission.h... Deadline: 12 May Please share All info: neuralcomputation.uk Sponsors: ARIA; Francis Crick Institute Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social

Abstract submission is open for UK Neural Computation 2025 @ Imperial College (9-11 July) neuralcomputation.uk/submission.h... Deadline: 12 May Please share All info: neuralcomputation.uk Sponsors: ARIA; Francis Crick Institute Organisers: @danakarca.bsky.social @neuralreckoning.bsky.social

I have a BSc and MSc in Cognitive Science. I think I basically agree with the article, that it’s not really a field, but I do think the crossover of AI-Psychology-Neuroscience-Philosophy is very valuable as the basis for a lot of other things. If nothing else, it produced psychologists who can code!

I know this site only reaches a subset of neuro/ cog professors. If you know a young professor in the area who would benefit from a week of targeted learning about doing good science, good mentoring, networking etc, it would be great if you could forward them: compneurosci.com/Neuro4Pros/i...

Last few tickets remaining for this one folks! ⬇️

Save the date! UK Neural Computation 2025 will be at Imperial College London 9 July: ECR day 10-11 July: main meeting 9 invited speakers, 4 talks from abstracts and many posters Abstract & registration opening soon Pls share! neuralcomputation.uk

And here we go! First position on my ERC grant is officially open. Fully funded 3.5 years PhD position at NetSI London working with me and the @nplab.bsky.social on modeling and reconstructing higher-order systems. Application deadline: 16th February 2025. Bring your A game!

We are hosting UKNC 2025 @ imperial! 💥 Fantastic set of speakers, see at neuralcomputation.uk Super exciting time to be working at the intersection of comp neuro/AI & applications. Save the dates: 9th July - ECR day 10th & 11th July - Main event Any questions get in touch! Plz share!

Save the date! UK Neural Computation 2025 will be at Imperial College London 9 July: ECR day 10-11 July: main meeting 9 invited speakers, 4 talks from abstracts and many posters Abstract & registration opening soon Pls share! neuralcomputation.uk

Looking forward to this!

New book "Explanation in Biology" with Cambridge University Press is out & open access! Covers (1) causal explanation & (2) non-causal/mathematical explanation in life sciences--bio, neuro, etc 🌿🧬🧠 Introduction to philosophical work on scientific explanation! www.cambridge.org/core/element...

Can confirm this is a true and accurate account of what’s happening to our department’s building Will leave you, dear reader, to consider the variety of ways we may be feeling about our institution at the moment

There's a strong computational neuroscience track, where you could learn with the best in the field (e.g. Srdjan Ostojic, Alex Cayco-Gajic, Boris Gutkin, @stepalminteri.bsky.social, Valentin Wyart) and the mediocre, too (i.e. yours truly).

I never fail to learn something from Mark's excellent round up! thank you for doing this :)