mcbi-amsumc.bsky.social
Researchers in the Department of Molecular Cell Biology and Immunology (MCBI) perform fundamental and preclinical research in the field of Cancer, Neuro and Mucosal Immunology at the
Amsterdam UMC.
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Altogether, this model highlights the potential of lymphoma-on-chip models to study the role of lymph node stromal cells in cancer development and progression. Stay tuned for updates on this project!
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(2) They also potentiated the ability of lymphoma cells to enhance lymphatic vessel permeability, although they did not affect permeability on their own.
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In addition, to survival this model hint at a role of FRCs in contributing to lymphoma cell metastasis in two different ways. (1) They promoted directional migration of lymphoma cells towards the lymphatic vessels.
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The addition of primary FRCs in the model improved the viability of the lymphoma cells, which was linked to increased production of interleukin-6, a known survival factor for hematological cancer cells.
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They describe the construction of a lymphatic vessel (red) surrounded by lymphoma cells (DLBCL, blue) and primary fibroblastic reticular cells (FRCs, green) in a hydrogel.
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Hi! Could you add us to the starter pack too, please? :)
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Hello Lucille! Could you add us to this starter pack, please?
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Hi Jon, could you add us if still possible? :)
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Hi! We’re late to the party but could you add us?
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We’re late to the party but could you add us too?