mgentili.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue @cellcellpress.bsky.social @jswlab.bsky.social @weallen1.bsky.social www.cell.com/cell/fulltex...

submitted 3 days ago • 0 comments

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA @cp-cellreports.bsky.social www.cell.com/cell-reports...

submitted 3 days ago • 0 comments

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫 We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

submitted 5 days ago • 3 comments

Out today in @naturegenet.bsky.social -- PERFF-seq! With @tsionabay.bsky.social , @ronanchaligne.bsky.social, Bob Stickels, Meril Takizawa, + Ansu Satpathy, we describe this new assay to study rare populations with programmable nucleic acid cytometry. 1/n www.nature.com/articles/s41...

submitted 160 days ago • 4 comments

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

submitted 15 days ago • 5 comments

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

submitted 17 days ago • 2 comments

#WeekendRead! #InterferonPower! Stunnenberg Pickkers Kox, Keramati &co show @natimmunol.bsky.org that 2 LPS injections in volunteers mimic the proinflammatory & immunosuppressive phases of #sepsis & found that IFNb treatment restores immune responsiveness in the suppressive phase!

submitted 38 days ago • 0 comments

Gomez-Diaz, @v-hornung.bsky.social et al. show that RNase T2 restricts TLR13-mediated #autoinflammation in vivo. rupress.org/jem/article/... 📘 In JEM #Immunology Collection: rupress.org/jem/collecti... #AAI2025

submitted 42 days ago • 0 comments

"Immune signaling through nucleotide-based second messengers is a widespread defense mechanism observed across organisms, from bacteria to animals. Zeng et al. discovered a base-modified nucleotide, deoxyinosine 5′-triphosphate (dITP), that acts as an antiviral immune signal in bacteria" #Immunology

submitted 52 days ago • 0 comments

#weekendreading📑🔬 Base-modified nucleotides mediate immune signaling in bacteria @science.org #microsky www.science.org/doi/10.1126/...

submitted 53 days ago • 0 comments

ZBP1 senses splicing aberration through Z-RNA to promote cell death www.cell.com/molecular-ce... www.cell.com/molecular-ce...

submitted 55 days ago • 0 comments

AAV vectors trigger DNA damage response-dependent pro-inflammatory signaling in human iPSC-derived CNS models and mouse brain @natcomms.nature.com @kajastelab.bsky.social www.nature.com/articles/s41...

submitted 60 days ago • 0 comments

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

submitted 64 days ago • 0 comments

Setdb2 regulates trained immunity by 2 complementary mechanisms: 1: increase glycolytic & inflammatory pathway genes via enhancer-promoter looping 2: increased promoter associated H3K9 methylation & repressed interferon response papers.ssrn.com/sol3/papers....

submitted 71 days ago • 0 comments

#WeekendRead! #NotOnlyInterferons! @nanyanlab.bsky.social &co show @cp-molecularcell.bsky.social that other than inducing pathogenic IFNs in lysosomal storage disorders, STING also play protective functions as a proton channel activating TFEB & inducing lysosomal repair www.cell.com/molecular-ce...

submitted 73 days ago • 0 comments

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment www.cell.com/cell-genomic...

submitted 82 days ago • 0 comments

THREAD The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X. By quite a lot. Release the Kraken... #AcademicSky #HigherEd #Altmetrics 1/11

submitted 82 days ago • 19 comments

In new study led by Brendan Larsen in collab w Veesler & Crowe labs, we map functional & antigenic landscape of Nipah virus receptor binding protein (RBP) www.biorxiv.org/content/10.1... Results elucidate constraints on RBP function & provide insight into protein’s evolutionary potential

submitted 424 days ago • 1 comment

Wonder which #innate responses in your animal models are shared with or distinct from humans? We did too! To answer, we teamed up with @mcampomd.bsky.social and the Hawn lab to compare human and murine alveolar and monocyte-derived #macrophage responses to #Mtb. (1/4) #TBSky #ImmunoSky #NewPI x 2

submitted 98 days ago • 2 comments

#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!

submitted 102 days ago • 2 comments

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

submitted 127 days ago • 9 comments

Excited to share our latest paper out today in @naturecomms.bsky.social ! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #ImmunoSky #InterferoSky

submitted 144 days ago • 1 comment

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

submitted 160 days ago • 3 comments

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

submitted 173 days ago • 5 comments

VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles www.nature.com/articles/s41...

submitted 568 days ago • 1 comment

1/ Introducing SCimilarity, a new foundation model to explore single-cell RNA-seq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. www.nature.com/articles/s41...

submitted 207 days ago • 2 comments

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS

submitted 211 days ago • 91 comments

@inflammasomelab.bsky.social was the lucky 100th added to this starter pack! Definitely one to follow for all the incredible #inflammasome #inflammation work they do! go.bsky.app/QqJ9AgB

submitted 205 days ago • 10 comments

Starter packs close to my heart (and hopefully others as well). Seen some new faces, here's a place to start! - Immunologists: bsky.app/starter-pack... - Insect Genetics & MolBio: bsky.app/starter-pack... - Drosophila folks: bsky.app/starter-pack... #Drosophila #Genetics #AcademicSky 🧪 🦋

submitted 205 days ago • 4 comments