Profile avatar
michael-erb.bsky.social
Chemical Biologist at The Scripps Research Institute
12 posts 485 followers 212 following
Regular Contributor
Posts 12 Comments 9

Make Thalidomide-for-morning-sickness Great Again

submitted 4 days ago • 0 comments

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start. If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

submitted 12 days ago • 4 comments

Congrats Brian and team. Such an elegant discovery. Small molecules can do it all!

submitted 19 days ago • 1 comment

check out this beautiful science from Xiaoyu, it'll cure your NIH blues for a few minutes

submitted 23 days ago • 1 comment

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support: grants.nih.gov/grants/guide...

submitted 23 days ago • 0 comments

Not more dramatic than MJ

submitted 47 days ago • 0 comments

Thanks for chairing a great session Katherine, really enjoyed it!

submitted 81 days ago • 0 comments

Maybe a good time to plug this awesome book edited by former PhD students Howard Hang (Scripps), Matt Pratt (USC), Jenn Prescher (UC Irvine), featuring chapters by leaders in the field including @jeremybaskin.bsky.social and a forward by yours truly.

submitted 88 days ago • 0 comments

Saturation mutagenesis CRISPR screen to map CREs of PD-L1 + TFs CRISPR LoF screen to identify known & novel trans-regulators + CUT&RUN to confirm new regulators + HiChIP enhancers/promoters contact maps Very impressive work by @nevillesanjana.bsky.social www.biorxiv.org/content/10.1...

submitted 94 days ago • 1 comment

Cool paper from Fleur Ferguson’s lab: onlinelibrary.wiley.com/doi/abs/10.1...

submitted 95 days ago • 0 comments

Dual-ligase PROTACs: a novel approach for enhancing TPD. By recruiting two distinct E3 ligases within a single molecule, we amplify degradation efficacy & potentially mitigate resistance occurrence. Great collabo with the Ciulli lab & friends at Promega. pubs.acs.org/doi/10.1021/...

submitted 95 days ago • 1 comment

Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization! onlinelibrary.wiley.com/doi/abs/10.1...

submitted 96 days ago • 2 comments