mufernando.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change

submitted 10 days ago • 2 comments

Reminder that SSE members in Brazil, Colombia, Mexico, India, and 152 low-income countries around the world can still get FREE registration for the virtual Evolution meeting! Please share with your colleagues: www.evolutionsociety.org/index.php?mo...

submitted 23 days ago • 0 comments

New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...

submitted 25 days ago • 15 comments

Our latest preprint about the effects of rescaling forward-in-time simulations in population genetics - www.biorxiv.org/content/10.1...

submitted 38 days ago • 1 comment

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

submitted 30 days ago • 3 comments

If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...

submitted 26 days ago • 1 comment

I’m old enough to remember when HHMI ran a competition for the best ideas they’d fund for the next 15 years. Some of us put huge efforts into that and went multiple rounds of review only to have the competition cancelled. Then our ideas started showing up in HHMI funded labs…

submitted 27 days ago • 12 comments

What happens to science under autocracy? The rise of the National Socialist Party in 1930s Germany provides an (admittedly extreme) example. Prior to the early 1930s, scientists at German institutions won a third of Nobels. 10 years later, that number was 5%, and has never recovered.

submitted 30 days ago • 14 comments

The PopSim Consortium wants you! Please join us on zoom on May 27 at noon Eastern Time (1600 UTC) to tell us you would like to see in the next version of stdpopsim! DM me for meeting link, or just sign up for our email list: lists.uoregon.edu/mailman/list... (1/3)

submitted 33 days ago • 1 comment

how can a program create a root owned file if my user does not have sudo privileges??? 🤨

submitted 47 days ago • 0 comments

I wonder how many species we could save from extinction with $435 million dollars...

submitted 68 days ago • 0 comments

Ah yes, the morphological species concept, so snakes are lampreys are hagfish! www.newscientist.com/article/2475...

submitted 69 days ago • 3 comments

Excited to see the final version of this paper with @samurscicop.bsky.social and Daniel Matute out in @genomebiolevol.bsky.social! We took a dive into the complicated demographic history of Aedes aegypti mosquitoes and its impact on the distribution of genetic diversity doi.org/10.1093/gbe/...

submitted 69 days ago • 4 comments

Grundler et al propose a new method to infer the geographic position of all our genetic ancestors www.science.org/doi/10.1126/... building on a method by Wohns et al www.science.org/doi/10.1126/.... My thoughts on the approach: www.science.org/doi/epdf/10.....

submitted 79 days ago • 1 comment

stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...

submitted 83 days ago • 0 comments

The collaborative paper on adding selection to stdpopsim is out! Learn about how to easily simulate realistic population genomic data with background selection and sweeps, plus some benchmarking of methods for demographic history, DFE, and sweep inference. www.biorxiv.org/content/10.1...

submitted 83 days ago • 0 comments

Accessible, realistic genome simulation with selection using stdpopsim https://www.biorxiv.org/content/10.1101/2025.03.23.644823v1

submitted 84 days ago • 0 comments

We are excited to share our new preprint describing the inclusion of selection models to stdpopsim, our community-maintained library with an extensive catalog of population genetic models. 1/n www.biorxiv.org/content/10.1...

submitted 83 days ago • 2 comments

To review what we from @washingtonpost.com are reporting out of the IRS today: - Projected tax revenue this year is down 10% ($500 billion) as Trump's downsizing is emboldening tax cheats - IRS is nearing an agreement with ICE to assist on mass deportations

submitted 85 days ago • 64 comments

1. For the past thirty years I've had the best job in the world.  I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

submitted 88 days ago • 39 comments

Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated

submitted 88 days ago • 612 comments

Amid the chaos, it was great to share results from the first Genomic History Inference Strategies Tournament at ProbGen25. Watch the talk to learn about the future of GHIST and @andrewhvaughn.bsky.social's nefarious metagaming of demographic inference. 😀 www.youtube.com/watch?v=3_dv...

submitted 90 days ago • 1 comment

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

submitted 92 days ago • 733 comments

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

submitted 97 days ago • 16 comments

I was once a Republican Limbaugh-watching dittohead, and I'm telling you. If you want to understand, you need to read George Lakoff's book on framing. www.chelseagreen.com/product/the-...

submitted 95 days ago • 1 comment

Hot take: it’s not phylogenomics if you only surveyed mitochondrial DNA.

submitted 96 days ago • 0 comments

As a former Fulbright Scholar (in Chile), I personally understand how terrifying this is. U.S. citizens around the world & foreign nationals in the U.S. — all Fulbright Scholars — have now had their incomes eliminated & are stranded. DOGE is an illegal, criminal operation that must be shut down.

submitted 100 days ago • 64 comments

DOJ, HHS, ED, and GSA Announce Initial Cancellation of Grants and Contracts to Columbia University Worth $400 Million (government press release) www.gsa.gov/about-us/new...

submitted 100 days ago • 18 comments

"No one is coming out of the sky to give you your grant money. Your citation portfolio won’t survive this market crash. Your credentials mean nothing. Everything is going to change." New for @undark.org undark.org/2025/03/06/o...

submitted 101 days ago • 5 comments

New paper early online at GBE: Pervasive conservation of intron number and other genetic elements revealed by a chromosome-level genome assembly of the hyper-polymorphic nematode Caenorhabditis brenneri. doi.org/10.1093/gbe/...

submitted 102 days ago • 0 comments

So weird & inscrutable that Musk & his core ideology keeps having strong connections to eugenics & race science, including the pseudonymous race science account Cremieux revealed to be ran by Jordan Lasker whose race science paper was at the center of a scandal involving NIH data misuse & deception

submitted 104 days ago • 7 comments

Leadership is doubling down, but GOP members are getting nervous about the budget’s extreme unpopularity. You can call your Representative now at 202-224-3121.

submitted 110 days ago • 560 comments

Thanks to Scientific American for featuring Stand Up for Science! 🧪☀️🌎 www.scientificamerican.com/article/stan... #standupforscience2025 #scienceforall

submitted 110 days ago • 0 comments

➡️ NIH grants in '23 included $26B of direct costs and $9B of F&A = 26% of total costs or 35% of total direct costs. These are LOW overhead rates for any R&D-intensive industry. Academic biomedical research is an efficient bargain. ➡️ Every $1 of NIH support generates ~$2.50 of economic activity.

submitted 114 days ago • 0 comments