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muniyappar.bsky.social
Senior Clinician and Endocrinologist NIDDK with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
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Fathers

Counterproductive

Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion academic.oup.com/jes/article/...

In the GRADE study, liraglutide led to the greatest increases in ISR, glucose sensitivity and potentiation, remaining above baseline at study end. However, with all therapies, β-cell function progressively declined after initial improvement #diabetes diabetesjournals.org/care/article...

Functional #insulin secretory defects occur in the remaining mass of beta cells during human #T1D pathogenesis not strictly correlated with the extent of insulitis #islets www.biorxiv.org/content/10.1...

Like many, I believed in this call, But now I see, I’m the fool after all. Won’t make the same mistake with my kids, Like my pops did, even if it’s hid. I’m an old fool, stuck in my ways, bound by beliefs the world forbids. I am an old fool, and I’ll stay this way.

Today's extract from Serving the Reich. What makes it worse is that I don't even need to add any explanatory comment, do I?

Introducing the Adipose Tissue Knowledge Portal integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men @cp-cellmetabolism.bsky.social @ki.se www.cell.com/cell-metabol...

Updated information on the subtyping of Primary Aldosteronism by means of AVS and key issues on the selection and preparation of patients, the optimal performance of the procedure, and the interpretation of its results #Adrenal #Hypertension academic.oup.com/edrv/advance...

"I never thought leopards would eat MY face." slate.com/technology/2...

from “Parable of the Talents” by Octavia Butler

Yep. I now have that from multiple reliable sources. "Retiring" starting, I think, COB tomorrow. For those who don't know Mike Lauer is (for the next day and a half) the NIH Deputy Director for Extramural Activities. This is the position that Sally Rockey had.

"I have never coveted affluence and luxury and even despise them a good deal. My passion for social justice has often brought me into conflict with people, as has my aversion to any obligation and dependence I did not regard as absolutely necessary." A. Einstein (1932) library.yu.edu/c.php?g=1073...

Bluetorial: Potential impact of “NIH” “plan” regarding indirect costs on institutions

Finding something you are good at and can make a living out of is such a privilege, I wish it for everyone. Most of all, I worry whether my generation will be the one that breaks the chain… which does not live up to the legacy of those who came before and the promise of those still to come.

Meritocracy?

I was naively hoping for a quieter day…

He is going to say "pinky swear you will protect our border. And buy more booze and stuff from us. " They will say yes. Won't actually buy the stuff. And he will declare victory Trumpenomics

I’m going to put my rich guy hat on and say I hope that Mexico and Canada issue equal, retaliatory tariffs and stick to them for an extended period. I apologize to all the people it will cost money and the businesses it will hurt. But it’s the only way for tariffs to be seen for what they are

"I have felt, and still feel, that there is no more worthy endeavor than to serve the country, its people, and the science which has given me so much joy.” —Dr. Ruth L. Kirschstein A fantastic thread about a great American👇

National Science Foundation suspends salary payments, leaving researchers unable to pay their bills www.statnews.com/2025/01/30/t... Story by @ericboodman.bsky.social

Not a great sign when Wired says it won't name at least two fo the people Musk has installed to run the Office of Personnel Management because they may be minors www.wired.com/story/elon-m...

I am taking a break from dealing with other issues to post a Bluetorial I had been already working on. This deals with tools for examining inclusion based on gender in the scientific community.

A.M. - Oh, shit, China can science too? [US stocks crash]. P.M. - Fuck it, let’s halt all of science in the U.S [🤪😵‍💫📉… 🤷‍♂️]. Nice one. wapo.st/4gfgcHQ

Want a great slogan for midterms? "If you FAFO and are struggling because of Trump policies, we understand. The Dems are here for you. Tell us how we can help you " You get the point. FAFO will be the theme. Be the solution.

They never understood, and still don't.

This really captures the moment don't you think?

The incoming leadership would be wise to seek counsel from Dr. Berg. His unparalleled experience is exactly what the NIH needs right now. Wish he were still at the NIH during this pivotal time.

simple point i tried to convey in the post I just shared. if someone does a nazi salute at a political rally, i don't need to do a critical biography or do some deep dive on why they did it. if you want a research project, sure, whatever. but that doesn't matter. They did it. Thats all that matters.

Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity www.thelancet.com/journals/lan... open-access

Good, keep it "on the table." Democrats, let them take ownership. This might be the best chance to drive some sense into the MAGA-supporting crowd.

SEOUL, South Korea (AP) - South Korean parliament votes to defy the country's president and immediately lift his martial law declaration.

Characteristically excellent piece by @anilananth.bsky.social on how close LLMs/AI are to AGI. Here AGI is defined as "a machine capable of the whole range of cognitive tasks that human brains can handle." But AGI boosterists (not Anil!) never really mean that... www.nature.com/articles/d41...

Bluetorial: Dealing with Deans 2: Instituting Basic Science

In politics clarity is its own opportunity. The storm of the 2024 election has created great clarity. The richest man in the world, Elon Musk, and 3rd richest man in the world, Jeff Bezos, are currently asking a group of Trump judges to end the right to organize & join a union in the United States.

A classic

Non–Insulin-Mediated Glucose Disposal is a major mechanism of postprandial glucose disposal in people with insulin resistance and inadequate insulin secretion. diabetesjournals.org/care/article...

Dr. Berg should end each of his posts with, "...and now you know the rest of the story." Must follow. I truly wish I had the opportunity to meet this man during his time at the NIH.

Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.