mzilberter.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

What's an acceptable (non-crazy) number of times to refresh a journal's manuscript tracking page while waiting for reviewer comments on a resubmission? Asking for a friend.

submitted 14 hours ago • 0 comments

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

submitted 2 days ago • 0 comments

Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9

submitted 2 days ago • 3 comments

Early neuronal reprogramming and cell cycle reentry shape Alzheimer's disease progression https://www.biorxiv.org/content/10.1101/2025.06.04.653670v1

submitted 6 days ago • 0 comments

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

submitted 8 days ago • 2 comments

What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

submitted 10 days ago • 1 comment

New work from our postdoc Seraphina Solders shows patterns of blood-brain barrier leakage in cognitively normal APOE4 carriers. BBB breakdown correlated with microstructural brain injury only in groups with high Alzheimer's disease risk (APOE4+, amyloid+, women) www.sciencedirect.com/science/arti...

submitted 11 days ago • 1 comment

Should mention that we are fortunate to have funding to support him, but thinking of all the other bright scientists who are not so lucky. No words…

submitted 13 days ago • 0 comments

A brilliant postdoc in my lab just received a final termination notice from NIA on his MOSAIC F32. He got an impact score of 20. Absolutely devastating.

submitted 14 days ago • 5 comments

Finally registered—looking forward to the inaugural Gordon Research Conference on Alzheimer’s Disease next month. Excited to connect with old and new friends in the AD field!

submitted 15 days ago • 0 comments

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

submitted 17 days ago • 2 comments

Exciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...

submitted 48 days ago • 0 comments

Thrilled (and honestly relieved) to receive the NOA from NIA for our project to dig deeper into the neuronal mechanisms of APOE4-induced network dysfunction.

submitted 22 days ago • 0 comments

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

submitted 24 days ago • 5 comments

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

submitted 28 days ago • 0 comments

ATTENTION Has anyone received a NOA this week (other than a no-cost extension? Please DM me or respond on signal jeremymberg.78 THANK YOU

submitted 34 days ago • 4 comments

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2. www.cell.com/neuron/fullt...

submitted 35 days ago • 1 comment

www.nature.com/articles/s41...

submitted 36 days ago • 0 comments

Astrocytic GLUT1 cKO in adult mice causes no pathology or behavioral deficits, increases astrocytic glucose consumption >2x, and reduces infarct size after stroke

submitted 36 days ago • 1 comment

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

submitted 43 days ago • 2 comments

I cite this in every electrophysiology/methods course I teach: a cautionary tale of how flawed assumptions and methodology can mislead an entire field. Case in point: using 10 mM glucose as the sole energy source in ACSF for neonatal neurons - despite their limited capacity to metabolize it. 1/2

submitted 43 days ago • 1 comment

Escaping grant anxiety at Big Sur

submitted 44 days ago • 0 comments

Looks like the final nail in the coffin for the excitatory GABA in development, 15 years after the theory was shown to be based on experimental artifacts (at the same institute, no less): “even during the first post-natal days, the net action of GABA is inhibitory, but not excitatory.” 🧠

submitted 44 days ago • 0 comments

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. www.cell.com/cell/fulltex...

submitted 45 days ago • 2 comments

🧪 The Sjöström Lab in Montreal is looking for a postdoc! We study cortical circuits, synaptic plasticity, and NMDAR signalling using custom 2-photon microscopy and optogenetics. We seek candidates with strong patch-clamp and/or 2-photon imaging expertise, and a relevant publication track record.

submitted 60 days ago • 1 comment

I feel seen

submitted 73 days ago • 0 comments

It’s here!

submitted 76 days ago • 0 comments

Published today in @alzdemjournals.bsky.social! We used connectome-based predictive modeling in autosomal dominant Alzheimer’s to predict tau levels & cognition in carriers years before dementia. Congrats to @vaibhavtripathi.bsky.social and team! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 84 days ago • 1 comment

β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions: Molecular Cell www.cell.com/molecular-ce...

submitted 84 days ago • 1 comment

Super cool. Apoe impact on cell specific landscape in AD. E2 enriched for oligodendrocyte and synaptic genes. www.cell.com/neuron/abstr...

submitted 85 days ago • 0 comments

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

submitted 86 days ago • 96 comments

New: Energy use shapes brain organization and development. We use gene expression maps from the @alleninstitute.bsky.social Human Brain Atlas to map the main energy metabolism pathways in the brain. Led by @moohebatpe.bsky.social @misicbata.bsky.social @goliashf.bsky.social and Justine Hansen 🧵

submitted 86 days ago • 2 comments

New preprint about SWRs, this time in HUMANS! 🤩 With @anna-maslarova.bsky.social and @JiyunShin, from @NYU, we’ve (i) developed a pipeline to analyze SWRs in intracranial EEG, and (ii) created ripmap, an open-source toolbox that allows versatile inspection and curation of events 🧵

submitted 94 days ago • 1 comment

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

submitted 97 days ago • 24 comments

@standupforscience.bsky.social in San Francisco!!!

submitted 97 days ago • 0 comments

Last-minute study section reschedule—better than a cancellation, I guess.

submitted 97 days ago • 0 comments

BREAKING: Federal judge issues a nationwide preliminary injunction blocking NIH from implementing its "Rate Change Notice" that would dramatically cut payments under grants. Judge Angel Kelley had previously issued a TRO blocking the change. storage.courtlistener.com/recap/gov.us...

submitted 99 days ago • 5 comments

Who's going? www.eventbrite.com/e/stand-up-f...

submitted 100 days ago • 0 comments