mzilberter.bsky.social
Neuroscientist at Gladstone Institutes /UCSF: electrophysiology & hippocampal network function, APOE4, and glucose metabolism in Alzheimer’s disease and epilepsy.
ORCID: 0000-0001-7164-8312
100 posts
913 followers
626 following
Prolific Poster
Conversation Starter
comment in response to
post
Huge congrats, Shannon -- can’t wait to see what comes out of this exciting work!
comment in response to
post
One issue I’ve always had with Clampex/700B is the lack of unified Vhold control. Despite telegraphing, 700B has its own Vhold, while Clampex can apply a separate one, especially during Membrane Test,so always have to be careful not to plunge the neuron to -140mV. Might not be your issue here though
comment in response to
post
Thanks for visiting and for the fascinating talk! Hope you enjoyed San Francisco.
comment in response to
post
Interestingly, this mismatch -- and its impact on neuronal function -- opened for us a whole new direction in Alzheimer's disease and epilepsy research - the link between glucose hypometabolism and neuronal hyperexcitability. 2/2
comment in response to
post
The changes are cell type–specific: oxidative stress disrupts glycolysis in neurons, creating a harmful feedback loop—glycolysis fuels the pentose phosphate pathway, their main antioxidant defense
comment in response to
post
Most likely a consequence of inflammation and chronic oxidative stress which we’ve shown to disrupt glucose utilization - with network hyperexcitability as the result.
comment in response to
post
Congratulations, super interesting!
comment in response to
post
Not totally sure what to make of it, but I know of grants within the payline that already received JIT requests after the same status change.
comment in response to
post
See one of @jeremymberg.bsky.social posts about expedited AC review - appears that some applications get fast-tracked through without official full AC meeting
comment in response to
post
comment in response to
post
That really sucks, hope they reschedule soon.
comment in response to
post
Watching post-POTUS speech interviews on C-SPAN—both Rs and Ds flagged AD research as a red line for budget cuts. Hope reason prevails in the end!