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navinbr.bsky.social
Research Fellow, Jay Shin Lab, Genome Inst Singapore PhD Eric Miska & Azim Surani Labs, Gurdon Inst, Cambridge Biochem Grad, Oxford
6 posts 993 followers 603 following
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Posts 17 Comments 4

Ahh it's out!!🤩 Deniz finds new functions for MLL3/4 (KMT2C/D) and H3K4me1 in regulating DNA replication timing and origin activity in ESCs. My unused CUT&Tag data from my PhD found its forever home-- and it was recycled by Deniz in such a brilliant fashion to make these discoveries!! 🥹

submitted 20 days ago • 2 comments

How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review with @gdiensthuber.bsky.social Now live! authors.elsevier.com/a/1kS2f3vVUP...

submitted 34 days ago • 0 comments

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9

submitted 35 days ago • 3 comments

Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...

submitted 36 days ago • 1 comment

I am thrilled to share our latest work, released today 🤩 www-nature-com.insb.bib.cnrs.fr/articles/s41... It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.

submitted 35 days ago • 11 comments

High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans https://www.biorxiv.org/content/10.1101/2025.01.14.632914v1

submitted 41 days ago • 0 comments

An interesting study characterising human embryo gastrulation! rdcu.be/d5VmN

submitted 45 days ago • 0 comments

Couldn't agree more with Paul Nurse that “Research institutes and units play a unique, beneficial role in the UK’s RDI landscape and this sector should be expanded....” So the MRC should rethink their regressive decision to close MRC Units. www.science.org/content/arti...

submitted 66 days ago • 1 comment

In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing #RNA #microRNA #miRNA #siRNA #argonaute🧬🧪 www.science.org/doi/10.1126/...

submitted 67 days ago • 1 comment

First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans Short 🧵 with highlights.

submitted 68 days ago • 3 comments

www.biorxiv.org/content/10.1... Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.

submitted 78 days ago • 5 comments

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

submitted 91 days ago • 12 comments

One enhancer can activate two endogenous genes simultaneously and across a TAD Boundary. Check out our new preprint. www.biorxiv.org/content/10.1...

submitted 112 days ago • 1 comment

Bluesky being added to altmetrics? That’ll be excellent!

submitted 104 days ago • 1 comment

Great hearing from Patrick Hsu this morning in GIS, A*STAR, on Bridge RNAs, AI and the Arc Institute model. Hope there'll be room for a philanthropic centrally-funded bio research institute in Singapore one day!

submitted 104 days ago • 0 comments

Virtual Embryo Shows Organs Forming in Exquisite Detail

submitted 105 days ago • 1 comment

FBXO22 deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature https://www.medrxiv.org/content/10.1101/2024.09.28.24314530v1

submitted 146 days ago • 0 comments