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niethammerlab.bsky.social
Cell biologist interested in how tissues sense and adapt to physical and chemical stress. Wound healing and regeneration. Quantitative imaging approaches. Nuclear mechanotransduction, ROS signaling & metabolism.
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I guess, I will survive buying nothing tmrw 😇 www.axios.com/2025/02/25/e...

Just two more manuscripts out, and I can finally get back to Logical Clustering. This is an innovative, experimentally-informed way for clustering gene expression data and logically integrating them with other mRNAseq exps and functional genomics and scRNAseq databases. github.com/niethamp/Log...

When did synovial joints evolve? @neelimasharma.bsky.social @neilshubin.bsky.social &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones 🧪 @plosbiology.org plos.io/3CTC8La

New preprint from the lab! www.biorxiv.org/content/10.1...

The Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US

Sharing outrage on social media is toothless and repetitive, only real protest matters.

While the US science ship is shaking, on a brighter note: two new preprints from the lab. In the first, we identify a long sought, enzyme of eicosanoid metabolism, 5-HEDH, which regulates inflammatory lipid synthesis and breakdown as a function of tissue redox state. www.biorxiv.org/content/10.1...

“But I don’t want to go among mad people," Alice remarked. "Oh, you can’t help that," said the Cat: "we’re all mad here..." (Lewis Carroll)

DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway https://www.biorxiv.org/content/10.1101/2025.02.05.636725v1

The G-protein coupled receptor OXER1 is a tissue redox sensor essential for intestinal epithelial barrier integrity. https://www.biorxiv.org/content/10.1101/2025.02.05.636712v1

While the US science ship is shaking, on a brighter note: two new preprints from the lab. In the first, we identify a long sought, enzyme of eicosanoid metabolism, 5-HEDH, which regulates inflammatory lipid synthesis and breakdown as a function of tissue redox state. www.biorxiv.org/content/10.1...

It’s so nice to be able to celebrate something this week. Newest work from the group! How are nuclear contents delivered to the cytosolic autophagy machinery while maintaining nuclear integrity? Nuclear envelope gymnastics! Cool role for Dnm1/Drp1. www.nature.com/articles/s41...

Are there any protests against these actions planned in the NYC area?

Capping the NIH indirects to 15% to save $4B makes as much sense as a person cutting their legs to lose weight.

🫣 All within one day: EOs to systematically weaken US research and put universities, innovation, and academic freedom on a chain. Meanwhile, one of the largest and most prestigious private research foundations is rolling over. Somebody turned off the lighthouse. What is happening here?

Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.

This is catastrophic for US research universities as it ignores the real cost of doing research. The US academic-gov’t partnership forged post-WWII is the greatest creator of knowledge in history and is critical to US economic and technological competitiveness.

www.statnews.com/2025/02/07/n...

IDCs are negotiated between Institutions and Congress. IANAL but so far as I can tell, this is totally illegal.

Researchers ‘stunned’ after HHMI abruptly cancels program to make science more inclusive www.statnews.com/2025/02/06/h... via @statnews.com

🙋Thought experiment: What would happen to science journals if HHMI, the MPG, NAS, and other prestigious science organizations would ask their members to refrain from providing any "impact" or "importance" assessment for any commercial journal whatsoever? And the rest of us would follow...?

The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...