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RIOK3 mediates the degradation of 40S ribosomes: Molecular Cell www.cell.com/molecular-ce...

submitted 2 days ago • 0 comments

The cover of the April issue of @cp-trendspharma.bsky.social. Gregory Howard and William Tansey review the current status, challenges, and future prospects of cancer treatments that target the ribosome. Aberrant ribosome production and function are hallmarks of cancer.

submitted 20 days ago • 1 comment

Nouvelle facette de la protéine Rqc2, sous-unité d’un système de sauvetage des ribosomes chez Saccharomyces cerevisiae

submitted 27 days ago • 0 comments

Congratulations to all the candidates who qualified for the #CNRS #CRCN competition in #Section21. Such brilliant science and incredible enthusiasm! Keep it up! c3n-cn.fr/2025/01/31/c...

submitted 31 days ago • 0 comments

A new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/

submitted 36 days ago • 1 comment

🚨New paper!🚨 A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬 Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏 Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social

submitted 49 days ago • 2 comments

Out just now @naturecomms.bsky.social: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: www.nature.com/articles/s41...

submitted 52 days ago • 2 comments

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...

submitted 53 days ago • 8 comments

#RésultatScientifique🔎 VIH : de nouvelles cibles pour l’immunité @onamy.bsky.social et ses collaborateurs révèlent que des antigènes du génome du VIH activent une forte réponse immunitaire, ouvrant de nouvelles pistes pour les vaccins ! 🧬

submitted 54 days ago • 1 comment

"these approaches estimate the number of ribosomes on a transcript, the translation initiation rate, and the overall number of translation events before its decay, all in a genome-wide manner" #rnasky #ribosome www.nature.com/articles/s41...

submitted 58 days ago • 3 comments

An important review we wrote with many colleagues! Important to read if you plan to use dual gene reporters! pubmed.ncbi.nlm.nih.gov/40033152/

submitted 69 days ago • 0 comments

Transcription & translation are central to molecular biology, producing mRNAs & proteins. While our cells compartmentalize these in nucleus & cytoplasm, in bacteria both occur simultaneously in the same compartment. Thus ribosomes translate mRNAs that RNA polymerase is currently transcribing 1/n 🧪

submitted 72 days ago • 5 comments

Don't miss the opportunity to come and work with us, as this is the last week to apply for our cell biology group leader position. Application deadline: Feb 28, 2025

submitted 77 days ago • 0 comments

Queuine: A Bacterial Nucleobase Shaping Translation in Eukaryotes #rnasky #rnabiology review by Ann Ehrenhofer Murray www.sciencedirect.com/science/arti...

submitted 83 days ago • 0 comments

I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...

submitted 83 days ago • 1 comment

www.cell.com/cell/fulltex...

submitted 101 days ago • 0 comments

A very interesting work from a great team! A must to read to understand stop codon readthrough. www.nature.com/articles/s41...

submitted 116 days ago • 0 comments

Congratulations to the Papenfort group and collaborators for this intriguing work uncovering the role of ProQ and its associated sRNAs in Vibrio motility! Grateful for the opportunity to be part of this discovery! academic.oup.com/nar/article-... #RNA #RIL-seq #Motility

submitted 132 days ago • 0 comments

Happy New Year 2025! I wish that this new year will be full of health, success, and happiness! 🎊@i2bcparissaclay.bsky.social

submitted 129 days ago • 0 comments

Bonne année 2025 à tous! J’espère que cette nouvelle année vous apportera tout ce que vous en attendez avec de beaux résultats et de passionnantes discussions scientifiques go.bsky.app/Kjf7vCa

submitted 130 days ago • 0 comments

#RNAsky #ribosomes Take notice!

submitted 135 days ago • 0 comments

I’m excited to speak at @KeystoneSymp #Microproteins: from Discovery to Applications, this February in Beverly MA! The deadline for Posters in January 15 2025. Join me to explore fascinating #Microproteins! keysym.us/KSMicroprote... #KSMicroproteins25 🧪🔎Microproteins

submitted 136 days ago • 1 comment

Boundaries between TADs often extend over considerable distance. But how variable is this width of boundaries? And does it matter? Find out in our new pre-print with the group of David Holcman. www.biorxiv.org/content/10.1...

submitted 137 days ago • 2 comments

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

submitted 142 days ago • 4 comments

Interesting work on a computational approach to develop orthogonal aminoacyl-tRNA synthetase/tRNA pairs in E. coli www.nature.com/articles/s41...

submitted 143 days ago • 0 comments

In vitro transcription (IVT) is a technology that facilitated the production of mRNA therapeutics and drove numerous breakthroughs in RNA biology. Our new study uncovers unexpected insights into the immunogenicity of in IVT RNAs. #RNA #IVT #Immunity academic.oup.com/nar/advance-...

submitted 143 days ago • 4 comments

Direct RNA sequencing is featured as one of The Scientist 2024 Top 10 Innovations. Read to find out how the latest direct RNA #nanopore sequencing kit and flow cell has improved accuracy and output, enabling a more complete picture of the landscape of RNA Read: www.the-scientist.com/2024-top-10-...

submitted 145 days ago • 0 comments

Bacterial ncRNAs influence various cellular functions & often have complex 3ry structures. ModT is a conserved #ncRNA found in 2,500 bacterial spp, shown here to regulate growth transition & sporulation in #Cdifficile via changes in c-di-GMP @helmholtz-hiri.bsky.social #PLOSBiology plos.io/4iIpgYm

submitted 146 days ago • 0 comments

I am taking advantage of the arrival of @i2bcparissaclay.bsky.social to remind #I2BC members that if you are not already listed in the starter pack please contact me. go.bsky.app/Kjf7vCa

submitted 146 days ago • 1 comment

Welcome @i2bcparissaclay.bsky.social on Bluesky! 👏

submitted 146 days ago • 0 comments

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center https://www.biorxiv.org/content/10.1101/2024.12.14.628468v1

submitted 147 days ago • 0 comments

Full room for the symposium « RNA small or long but all Champions » supported by sfgenetique.bsky.social

submitted 150 days ago • 1 comment

Ce soir c’est la remise de la médaille d’or du #CNRS à la #mutualite.

submitted 151 days ago • 0 comments

Demain remise de la médaille d’or du #CNRS à Edith Heard pour sa brillante carrière. Est que la #SNCF me permettra d’y aller en #RERB ? Mystère j’ai l’impression que pour le moment c’est du 20/80 😩

submitted 152 days ago • 0 comments

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

submitted 153 days ago • 1 comment

Evidence for the pairing of mRNA exiting ribosomes acting as a Driver of unidirectional forward bypassing: Its cessation permits Backwards scanning https://www.biorxiv.org/content/10.1101/2024.12.09.627546v1

submitted 153 days ago • 0 comments

La liste des postes ouverts au concours du CNRS est au JO. www.legifrance.gouv.fr/jorf/id/JORF...

submitted 153 days ago • 5 comments

Last month of the year! 🎊 Amazing things happened at #GenomeBiologyI2BC in 2024. Check out our #I2BC Scoop-it and see for yourself: www.scoop.it/topic/i2bc-p...

submitted 154 days ago • 0 comments