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peacockflu.bsky.social
Virologist - Influenza and Coronaviruses
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Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...

1 week left to apply for this!

Core-funded postdoc position at The Pirbright Institute, Surrey, UK (just outside London), in the group of Professor Ian Brown. Working on H5N1 avian influenza virus evolution and development of cross-reactive vaccines. www.pirbright.ac.uk/careers-and-...

Closing this friday!

Because there's not enough going on: Arizona has found #H5N1 #birdflu in milk and it looks like yet another spillover from wild birds. www.statnews.com/2025/02/14/a...

There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested: #immunosky #virology 🧪 www.jobs.cam.ac.uk/job/50254/

Just out: PhD opportunity with Dr Marie Di Placido, Dr Stephen Dunham, Prof Munir Iqbal, Prof. Janet Daley and myself looking at how different livestock species make antibody responses to H5N1. www.findaphd.com/phds/project...

Core-funded postdoc position at The Pirbright Institute, Surrey, UK (just outside London), in the group of Professor Ian Brown. Working on H5N1 avian influenza virus evolution and development of cross-reactive vaccines. www.pirbright.ac.uk/careers-and-...

Just out: PhD opportunity with Dr Marie Di Placido, Dr Stephen Dunham, Prof Munir Iqbal, Prof. Janet Daley and myself looking at how different livestock species make antibody responses to H5N1. www.findaphd.com/phds/project...

4 dairy herds in Nevada recently diagnosed with #H5N1 #birdflu were infected with a different version of the virus than has been spreading in cows elsewhere. Evidence of a second (at a minimum) spillover points to the challenge of stopping spread, experts say. www.statnews.com/2025/02/05/u...

The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain which has circulated in wild birds, making prospects for containment in cows appear dim.

This is major #H5N1 news: While, so far, dairy cows in the US were infected by genotype B3.13, genotype D1.1 was found in Nevada via the national milk testing strategy. If confirmed that it's not a bird intrusion into a milk tank, this means that there has been a new spillover into dairy cows.

Why can't these viruses be friends? During her PhD, Anna Sims showed that influenza viruses segregate into genetically-distinct lesion through a process called superinfection exclusion. In a new preprint, she shows that the same process also applies for SARS-CoV-2 www.biorxiv.org/content/10.1...

Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2) rdcu.be/d73te

Four years in the making, our paper is finally out! This was an enormous team effort and a great end to my time at @crick.ac.uk in @davidlvbauer.bsky.social 's lab 🧪🦠🧬

🎺 PhD studentship available at @lshtm.bsky.social and RVC! @influenzal.bsky.social and I are advertising for a project to investigate the unexpected phenomenon that mutagenic antiviral drugs can give rise to viruses with hundreds of mutations which are still viable. 🧵 www.lshtm.ac.uk/study/fees-a...

In new study, we find dramatic differences in specificities of serum neutralizing antibodies in infants w single infection by a recent SARS-CoV-2 strain versus adults/children imprinted by an early viral strain. www.biorxiv.org/content/10.1...

Here we provide evidence of henipaviruses in North America with the discovery of Camp hill virus in the Northern Short-Tailed Shrew, Alabama. Early release article available from EID wwwnc.cdc.gov/eid/article/... #virology

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Wendy Barclay and I are recruiting a postdoc for a project investigating the evolution of swine influenza viruses and how this impacts future pandemic potential. Job is based at Imperial's South Kensington campus. Drop me a DM/email for more details. www.imperial.ac.uk/jobs/search-...

Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome: [1/N] www.biorxiv.org/content/10.1...

Lots of new viruses (and other known pathogens) here, especially in carnivores and rodents. Of most interest, a bi-segmented coronavirus sampled from diseased red (lesser) pandas (Ailurus fulgens) and that represents a new genus. Work led my Mang Shi and Shuo Su. www.biorxiv.org/content/10.1...

Our lab's 2nd preprint is now on bioRxiv! Led by Jordan Ort, we made H5 datasets that enable rapid clade assignment with Nextclade. We released these builds in the spring (due to cow flu) & finally wrote the paper! TLDR: it's fast, easy, accurate, and we hope, useful www.biorxiv.org/content/10.1...

🚨 New preprint alert 🚨 We searched for the presence of coronaviruses in >200 bat individuals across Spain 🦠🦇. We recovered 6 complete coronavirus genomes, including 3 novel species. One of them could use bat and human ACE2 for entry. www.biorxiv.org/content/10.1...

It is finally out, our beautiful work 😍 You have never seen so many Spike at once 😎 But the best thing has been working elbow to elbow with my best pal, @wfurnon.bsky.social

Another PhD studentship is available for Oct 2025 start! In a collaboration between the @pirbrightinst.bsky.social and us, you will be investigating the role of novel avian coronavirus accessory genes. See here for more details! www.findaphd.com/phds/project... Deadline 17 Feb, funded for UK only.

Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. https://www.biorxiv.org/content/10.1101/2025.01.06.631435v1

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

🚨🔔 Delighted to see this piece of work from @cvrinfo.bsky.social now out in @naturemicrobiol.bsky.social ! Indeed, it really reflects what multidisciplinary team effort can be. Guess what? Spike of #SARSCoV2 is not just about antigenicity/immune evasion… doi.org/10.1038/s415...

Most of my time this year has been working on this new dengue nomenclature system with a huge and brilliant set of global collaborators!! Glad to see other people think it's worthwhile too 😎 @nathangrubaugh.bsky.social

Happy to share the first research article from my lab, now open access at Nature Communications! We report a single mutation (T199I) outside of the H5 receptor binding site (RBS) dramatically increases RBS flexibility and allows for broader binding to its receptor. www.nature.com/articles/s41...

I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant. If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch! Application deadline: January 19th. Please share with your networks 🙏 Job link: tiny.cc/7v33001

I’m pleased to share that we FINALLY submitted our latest manuscript on SARS-CoV-2 cryptic lineages and what they tell us about the origins of COVID-19. This was a ton of work. medrxiv.org/cgi/content/... 1/

Just in time for the holidays, our lab has just submitted our first lab led paper www.biorxiv.org/content/10.1...! We use phylodynamics to reconstruct how H5N1 got to North America and spread so rapidly. Full thread coming post holidays, but for now, super proud of @lambod50.bsky.social

In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation www.biorxiv.org/content/10.1...

CDC just confirmed the first severe case of #H5N1 in the US in a patient in Louisiana. This virus seems to be the same genotype D1.1 that is spreading in birds at the moment (so not the cattle genotype B3.13) that severely sickened the teenager in Canada.