physfoley.bsky.social
Physics of membranes and self-assembly || Biophysics postdoc at Johns Hopkins || Previously Penn State -> Carnegie Mellon || views are now yours, good luck || /dʒɪf/ ||
www.samuelfoley.com
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Actually on re-reading your reply I do think I have a nitpick that the size of the basin of attraction doesn't really matter, just that there is another basin of attraction (of equal or lower energy) that it switches between. The global lowest energy fixed point could have a tiny but steep basin.
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Yes, I agree. I think I would go as far as saying it has to be locally stable, otherwise it's hardly classifiable as a macroscopically observable state (in the sense of coarse-graining the region around a stable minimum into a meso-scale state). But this makes transition "states" iffy.
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I'm not sure that bite-sized social media posts are the best forum to debate the merits of different scientific frameworks.
I'm also not a major proponent of any particular raft hypothesis, but it seems rather likely that membrane phase behavior couples to membrane protein function.
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(To your point about distributions, here I'm being a bit looser by what I mean by "a structure", more referring to the average structure that an equilibrium distribution is "centered" on)
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This evolved out of someone repeatedly referring to a structure as metastable when in all examples given it is the "final" (average) structure arrived at by a system, without significant sampling of other structures. To me, that's stable (equilibrium), not metastable.
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en.m.wikipedia.org/wiki/Headlin...
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The one that I still hate the most is what I like to call the "tooth lattice", which shows up frighteningly often in pop-science articles related to membranes
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"LLM", sung to the tune of "monorail"
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There is an actual Star Wars comic where Indiana Jones discovers the skeletal remains of Han Solo on the crashed Millennium Falcon in the middle of a jungle.
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"jedis"
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Man you carefully constructed this to piss off Star Wars nerds, I am actively restraining myself
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It's wild how straightforward the problems & their metrics are here as well. They're just scaling the size of Tower of Hanoi, Checker Jumping & other well-defined puzzles to the point both LLM & LRM approaches fail & use simple metrics like accuracy/scale to compare models. This seems long overdue:
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If you burn down a forest, you don't miss out on lumber for just that season. You have to replant all the trees, nurture them, and wait for them to grow.
The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.
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I'm just sitting here trying to focus on finishing my NIH K99 application like
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What's fascinating to me here is that although the configuration space distance between them is increasing exponentially the whole time, it doesn't become visually noticeable until we've nearly maxed out that distance metric
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The scientific community needs to understand that the sort of people who used to fulminate about teaching evolution at school board meetings are now running federal agencies and eager to use that power.
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I cannot imagine the mental state I would have to be in to think of sending a research proposal to someone when I don't even know what's in the document.
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Also, $200 a year? For an individual license? Makes it tempting to drop Overleaf altogether.
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I think it's 15% of the 2.4+5.2+3.9, plus the first 8.6