planetaoptimism.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

youtube.com/watch?v=bnkK...

submitted 5 hours ago • 0 comments

Protective effects and mechanisms of #quercetin in animal models of #hyperuricemia: A systematic review and meta-analysis www.sciencedirect.com/science/arti...

submitted 9 hours ago • 0 comments

Comprehensive metabolomic/lipidomic characterization of patients with mitochondrial ATP synthase, short-chain acyl-CoA dehydrogenase and combined variant deficiencies www.sciencedirect.com/science/arti...

submitted 9 hours ago • 0 comments

#Cold and #longevity: Can cold exposure counteract #aging? www.sciencedirect.com/science/arti...

submitted 11 hours ago • 0 comments

Oleuropein increases resting skeletal muscle fractional PDH activity but does not influence whole-body metabolism Chronic OLE resulted in higher skeletal muscle fractional PDH activity in healthy, older males, which may impact resting energy metabolism www.sciencedirect.com/science/arti...

submitted 10 hours ago • 0 comments

#Exercise, Gut #Microbiome, and #Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms www.sciencedirect.com/science/arti...

submitted 12 hours ago • 0 comments

Improved glucose tolerance and low insulin make a person healthy and live longer. Triglycerides IR marker. youtu.be/YIfLuTkvawY?...

submitted 17 hours ago • 0 comments

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model https://www.biorxiv.org/content/10.1101/2025.02.20.639336v1

submitted 21 hours ago • 0 comments

After a long delay time to catch up on Unfoled Protein Response related papers! @biomednews.bsky.social biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/...

submitted 1 day ago • 2 comments

Americans proposed that Ukraine concede half of the profits from its mineral rights in perpetuity... in exchange for essentially nothing. This is not a monetary proposition, let alone a "deal," but rather the demand that Ukraine become a permanent American colony. snyder.substack.com/p/recoup-the...

submitted 1 day ago • 142 comments

Glyco-STORM: Nanoscale Mapping of the Cellular Glycosylation Landscape https://www.biorxiv.org/content/10.1101/2025.02.19.639131v1

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In a study involving >500 people, the AI identified a range of infections and health conditions, as well as whether participants had received a flu vaccine. https://go.nature.com/4gPUpGT

submitted 2 days ago • 2 comments

A little biochemistry to understand metabolism and healthy eating: youtu.be/cu8W9tqpARc?...

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www.frontiersin.org/journals/nut...

submitted 2 days ago • 0 comments

A little biochemistry to understand metabolism and healthy eating: youtu.be/cu8W9tqpARc?...

submitted 2 days ago • 0 comments

www.frontiersin.org/journals/nut...

submitted 2 days ago • 0 comments

The DOGE firings have nothing to do with “efficiency” or “cutting waste.” They’re a direct push to weaken federal agencies perceived as liberal. This was evident from the start, and now the data confirms it: targeted agencies overwhelmingly those seen as more left-leaning. 🧵⬇️

submitted 2 days ago • 244 comments

Trump’s Golden Era risks the tarnish of corruption. My thoughts on the pause on the enforcement of the Foreign Corrupt Practices Act in The Contrarian.

submitted 3 days ago • 31 comments

Hypoxia induces ferroptotic cell death mediated by activation of the inner mitochondrial membrane fission protein MTP18/Drp1 in invertebrates www.sciencedirect.com/science/arti...

submitted 4 days ago • 0 comments

The ongoing global epidemic of #MASLD & its close pathogenic and predictive relationship with the non-communicable diseases of #cardiovascular disease, #cancer, #obesity, & type 2 #diabetes, allow the inclusion of MASLD as a new non-communicable disease thelancet.com/journals/lan... #OpenAccess

submitted 4 days ago • 0 comments

Biologic interplay between the #gut #microbiota and hypothalamic-pituitary- #thyroid axis. Dysbiosis via increased production of proinflammatory cytokines and a molecular mimicry mechanism induces a decrease of short-chain fatty acids and abnormal iodine uptake. www.sciencedirect.com/science/arti...

submitted 4 days ago • 0 comments

Huge congratulations to @hagesprenger.bsky.social and the rest of the team for this great work Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST: Cell Metabolism www.cell.com/cell-metabol...

submitted 4 days ago • 1 comment

Any discussions regarding the future of Ukraine without Ukraine and Europe is doomed to fail. This didn't work out in Syria where the odds were even less in favor with the rebels and yet they won. Those involved in this folly will find that out pretty soon.

submitted 5 days ago • 15 comments

We summarize the specific mechanisms underlying "ammonia death" in CD8+ Teff cells and propose potential directions for future research that could leverage this knowledge to improve cancer treatment outcomes. www.sciencedirect.com/science/arti...

submitted 5 days ago • 0 comments

CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach https://go.nature.com/42XLYpK

submitted 5 days ago • 1 comment

#Mitochondrial targeted therapy in #MAFLD www.sciencedirect.com/science/arti...

submitted 5 days ago • 0 comments

Another mitoribosome structure hits the stage, this time from Danica and @fraserlab.bsky.social labs! The field is growing, expanding into antibiotics research with new groups and young talented scientists joining. Great to see fresh perspectives shaping the field! 👏 academic.oup.com/nar/article/...

submitted 5 days ago • 0 comments

A man who seemed genetically destined to develop Alzheimer’s disease while still young has reached his mid-70s without any cognitive decline ― in only the third recorded case of such resistance to the disease https://go.nature.com/4hUfvVy

submitted 6 days ago • 0 comments

Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle https://www.biorxiv.org/content/10.1101/2025.02.11.637778v1

submitted 6 days ago • 0 comments

Triterpenoid CDDO-EA Protects from Hyperglycemia, Hyperinsulinemia, and Obesity by Decreasing Energy Intake https://www.biorxiv.org/content/10.1101/2025.02.12.636924v1

submitted 6 days ago • 0 comments

Therapeutic Inhibition of Metalloproteases by Tetracyclines during Infection by Multi-Drug Resistant Pseudomonas https://www.biorxiv.org/content/10.1101/2025.02.14.638345v1

submitted 6 days ago • 0 comments

According to our review, the above natural products can effectively treat arthritis without causing any significant side effects. Anyone can consider the aforementioned products as dietary supplements for the management of arthritis. www.sciencedirect.com/science/arti...

submitted 7 days ago • 0 comments

#Quercetin preserves #mitochondria-endoplasmic reticulum contact sites improving mitochondrial dynamics in aged myocardial cells link.springer.com/article/10.1...

submitted 7 days ago • 0 comments

Sleep Loss and Substance Use Disorders: An Issue from Adolescents to Adults www.mdpi.com/3184230

submitted 7 days ago • 0 comments

This study has shown that chronic β-adrenergic receptor (β-AR) stimulation causes cardiac hypertrophy associated with sodium-driven water retention in the heart and increases the accumulation of body sodium, potassium, and water at the tissue level. www.sciencedirect.com/science/arti...

submitted 7 days ago • 0 comments

Our results provide a novel mechanism of #berberine action, which targets both the bacterium and the host to exert its #antibacterial effects. www.sciencedirect.com/science/arti...

submitted 7 days ago • 0 comments

The test could be used for routine screening to improve pancreatic cancer's low survival rate https://go.nature.com/3X03Oor

submitted 7 days ago • 1 comment

#Nrf2 activators for the treatment of rare #iron overload diseases: from bench to bedside www.sciencedirect.com/science/arti...

submitted 8 days ago • 0 comments

#Earthing is beneficial for improving reduced #stress, #insomnia severity & daytime sleepiness. Results contribute to increasing sleep time and provide preliminary evidence for the beneficial effect of increasing sleep quality via reducing #stress response. www.sciencedirect.com/science/arti...

submitted 8 days ago • 0 comments