popkirov.bsky.social
Neurologist interested in dissociative seizures and other functional neurological disorders
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Allerdings hat dieser sorgfältig recherchierte Artikel meine Einschätzung zu den gängigen POTS-Diagnosekriterien (wie sie auch im Kapitel wiedergegeben werde) etwas geändert: mecfsskeptic.com/the-problems...
Zumindest würde ich die Diagnose nicht mehr bei asymptomatischem Pulsanstiegs stellen.
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Orthostatische Intoleranz/POTS werden mit den relevanten Unterscheidungsmerkmale unter den Differenzialdiagnosen des chronische Schwindels gelistet. Bei den Sensibilitätsstörungen wird die Abgrenzung zur PNP besprochen, aber nicht auf die vielen Unterformen der PNP dezidiert eingegangen.
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Thanks Tim - would love to see those
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If you've made it to 55, your average life expectancy is 85, and at 85+ there'll be a solid rate of "lifetime" dementia defined strictly...
ourworldindata.org/grapher/life...
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Some relevant references:
doi.org/10.1016/j.co...
doi.org/10.1556/2060...
doi.org/10.1212/wnl....
Does your hand tingle? And do you have a favourite explanation for functional sensory symptoms?
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I like using the metaphor of a turned up sensory 'volume dial'. Once turned up, for example due to an injury, the dial can remain in this heightened state for a long time, making one persistently aware of unpleasant background noise where once there was silence.
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About 1/3 of people feel some tingling in their hand when looking at it intently for 20-30 s (left works better). This experience is an excellent starting point for explaining sensory gating, somatosensory amplification or central sensitization in simple terms.
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They write "self-reported physical function improved statistically and clinically significantly in the intervention group after 2 to 8 outpatient encounters" and I think that's correct. In the other two instances they add "compared to controls" which I agree can be challenged.
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I think it's fair to say that observed benefits were 'clinically important', and group difference were 'statistically significant' and effect size was moderate.
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Isn't there a difference between "treatment effect" as in how does the intervention affect participants, and "treatment effect" as in how much additional benefit does the intervention bring compared to placebo?
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The treatment effect was about +17 points in the intervention group, suggesting a clinically meaningful change (on average, not necessarily for every patient). The difference between groups should be calculated as effect size, not absolute points. Cohen's d looks to be around 0.5, which is solid.
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@ihoeritz.bsky.social
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I've heard good things about Models of the Mind by Grace Lindsay but haven't read it myself. My own attempts to get into computational neuroscience were repeatedly thwarted by mathematics...
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Look forward to this. Reminds of a great paper I keep coming back to: doi.org/10.3389/fnhu...