renesugar.bsky.social
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www.sciencedirect.com/science/arti...
"Desensitization provided a way to administer medications safely and may be extrapolated in future cases in patients with allergies or when starting new medications."
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www.sciencedirect.com/science/arti...
"Rapid desensitization protocols have been published for non-IgE-mediated reactions, but mechanisms of action are still largely unclear."
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www.sciencedirect.com/science/arti...
"Desensitization is a method of preventing a negative immune response by increasing progressive doses until a full therapeutic dose is achieved, thus providing basal and mast cell stabilization."
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www.sciencedirect.com/science/arti...
"Anaphylactoid reactions in contrast, are not mediated by IgE, but still result in a release of inflammatory mediators."
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www.sciencedirect.com/science/arti...
"Conclusion: Medication administration in the setting of MCAS is challenging as patients may react randomly."
"Drug-induced type I hypersensitivity reactions result from the release of mediators from IgE-sensitized mast cells."
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www.sciencedirect.com/science/arti...
"who underwent successful desensitizations with ceftriaxone as empiric pneumonia therapy and azithromycin to treat Chlamydia pneumoniae infection once cultures were finalized."
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www.sciencedirect.com/science/arti...
"Results: We present the first reported case of a patient with MCAS with a history of anaphylactic reaction to cephalosporins and azithromycin"
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www.sciencedirect.com/science/arti...
"Methods: In our patient with Chlamydia pneumoniae and hypersensitivity to cephalosporins and azithromycin, a protocol consisting of progressive amounts of ceftriaxone and azithromycin until therapeutic doses were clinically tolerated."
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www.sciencedirect.com/science/arti...
"The development of rapid desensitization protocols for the treatment of drug hypersensitivities is aimed at providing essential medications while protecting patients from severe reactions induced by anaphylactic and anaphylactoid mechanisms."
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www.sciencedirect.com/science/arti...
"Introduction: Mast Cell Activation Syndrome (MCAS), is defined by episodic symptoms consistent with mast cell mediator release, closely resembling anaphylaxis and may be triggered by multiple agents including medications."
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Fourth Kevin O'Leary today:
x.com/poneywilliam...
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Third AI generated Mark Carney:
x.com/KhurshiES/st...
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Second AI generated Mark Carney:
x.com/arta_harry/s...
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Third one with Kevin O'Leary:
x.com/bruna_corna/...
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Second one with Kevin O'Leary:
x.com/sarrahletty/...
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Another one picturing Kevin O'Leary:
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Another one picturing Mark Carney and Trump:
x.com/MmnMika/stat...
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3/ A much more detailed version of the first graph (same 830 day period). I think of my recent history in terms of the landscape of this productivity plot!
More recent improvements dwarf those I made a fuss about in my post-covid analysis threads: x.com/Z3R0Gravitas...
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Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter #HIF1α #EBV #MECFS #LongCovid
bsky.app/profile/rene...
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A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1α #MitoQ #HIF1α #MECFS #LongCovid
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Multiple Sclerosis and #MitoQ: A Personal Perspective #EBV #MECFS #LongCovid
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Multiple Sclerosis and #MitoQ: A Personal Perspective #EBV #MECFS #LongCovid
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ALSUntangled No. 29: MitoQ
www.tandfonline.com/doi/full/10....
"It should be noted that these trials were using MitoQ at 40 mg or 80 mg daily."
"This is much higher than the 10 mg daily dosage recommended on the MitoQ website."
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www.ncbi.nlm.nih.gov/pmc/articles...
"Further investigation shows that the mitochondria in cell lines with EBV Type 3 latency produce higher levels of mitochondrial ROS that are responsible for the activation of the Keap1-NRF2 pathway, compared with Type 1 latency."
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The master antioxidant defense is activated during EBV latent infection
www.ncbi.nlm.nih.gov/pmc/articles...
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Succinate undermines FOXP3 stability and disrupts Treg cell function #MECFS #LongCovid
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"We propose that drugs that induce HIF-1α protein accumulation are good candidates for development of a lytic-induction therapy for treating some EBV-associated malignancies."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"Thus, we conclude that HIF-1α plays central roles in both EBV’s natural life cycle and EBV-associated tumorigenesis."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"Furthermore, most BZLF1-expressing cells observed in lymphomas induced by EBV in NSG mice with a humanized immune system were located distal to blood vessels in hypoxic regions of the tumors."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"HIF-1α activity also accumulated along with Blimp-1α during B-cell differentiation into plasma cells."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"Human oral keratinocyte (NOK) and gingival epithelial (hGET) cells induced to differentiate by incubation with either methyl cellulose or growth in organotypic culture accumulated both HIF-1α & Blimp-1α, another cellular factor implicated in lytic reactivation"
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"Importantly, expression of HIF-1α induced EBV lytic-gene expression in cells harboring wild-type EBV, but not in cells infected with variants containing base-pair substitution mutations within this HRE."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"HIF-1α did not activate transcription from the other EBV immediate-early gene, BRLF1."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"HIF-1α directly bound the promoter of the EBV primary latent-lytic switch BZLF1 gene, Zp, activating transcription via a consensus hypoxia-response element (HRE) located at nt -83 through -76 relative to the transcription initiation site."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"ShRNA knockdown of HIF-1α significantly reduced deferoxamine-mediated lytic reactivation."
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pmc.ncbi.nlm.nih.gov/articles/PMC...
"or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens."