rhyscienceallan.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

One of the best workshops out there if you work on #Enhancers #GeneRegulation #Epigenomics 👇

submitted 6 days ago • 0 comments

Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations www.cell.com/cell-genomic...

submitted 6 days ago • 0 comments

Happy to share our lab's first review article. We provide an overview of the discovery of adaptive type 2 immunity and discuss the pathways regulating Th2 cell biology with a focus on chronic allergic diseases. Congrats to @jmannion.bsky.social. #ImmunoSky 🧪

submitted 7 days ago • 1 comment

Fun collaboration with @gebhardtlab.bsky.social and @akispapantonis.bsky.social: CTCF and cohesin bind increasingly efficiently to chromatin and instruct the establishment of chromosome structure in zebrafish embryos

submitted 10 days ago • 0 comments

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

submitted 10 days ago • 8 comments

The advert is officially live and you can apply online here: tinyurl.com/yd5bsvfb

submitted 10 days ago • 2 comments

Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqAr...

submitted 12 days ago • 0 comments

Fascinating functional genomics session at #lorneGenome25 - covering humans, bats, jellyfish, and snakes 🦇🐍 Live posting from the wonderful @lizworthey.bsky.social if you would like to follow along (now or later) 🌟

submitted 14 days ago • 1 comment

Up first Michael Wilson speaking on Evolutionarily conserved cis regulatory elements in cardiac development and congenital heart disease #LorneGenome25

submitted 14 days ago • 0 comments

It is another gorgeous morning in Lorne so I hope you’re all out enjoying it, or resting up after the poster session last night, so you’ll be ready for science at 9am. We’ve got some great research coming up in Session 7 - Transcriptional Regulation first up at #LorneGenome25 today.

submitted 14 days ago • 0 comments

Learning to catch a wave between sessions #lornegenome #lornegenome2025

submitted 15 days ago • 0 comments

Packed house for the first concurrent session-Genome in disease #lornegenome2025

submitted 15 days ago • 0 comments

Up next Timothy Johanson discussing Exploring the genome of immune memory in four dimensions #LorneGenome25

submitted 15 days ago • 0 comments

Up next Yi Zhang discussing Naïve pluripotent stem cell specification by GABPA and PRC2 #LorneGenome25

submitted 15 days ago • 0 comments

Up now Silvia Velasco speaking about Unlocking the potential of brain organoids for understanding and treating neurodevelopmental disorders #LorneGenome25

submitted 15 days ago • 0 comments

After morning tea, #LorneGenome25 delegates have a tough choice: Session 5A Computational Biology & Bioinformatics in the main heritage ballroom or Session 5B Genome in Disease in the Heritage Room behind the restaurant?! I’ll be running between the two as there are talks I can’t miss in both.

submitted 15 days ago • 0 comments

It’s a beautiful Monday morning in Lorne! Lovely to see so many delegates out enjoying it. Looking forward to seeing you all at 9am for some equally beautiful science in Session 4: Chromatin & Disease! #LorneGenome25

submitted 15 days ago • 0 comments

AV: BRCA2 single mutant alleles confer risk of breast, ovarian, prostate, oesophageal cancers via chromosomal instability - with many lesions being chromatid type suggesting defects in DNA repair (HR) and replication fork protection (RFP) #LorneGenome25

submitted 16 days ago • 0 comments

Up next Dr. Anne Goriely speaking on Selfish selection of de novo mutations in the male germline - Anne Goriely #LorneGenome25

submitted 16 days ago • 0 comments

Up now the Genetic variation session kicking off with Deciphering the cis-regulatory logic of plant genomics at single-cell resolution by Bob Schmitz #LorneGenome

submitted 16 days ago • 1 comment

I have created a Bsky account just in time for #LorneGenome25 so that I can post from (and about) the meeting. I am very proud of the program that the Organising Committee has pulled together (www.lornegenome.org) and can't wait to see you all on Sunday! Looking forward to some science by the beach!

submitted 18 days ago • 1 comment

Wow, this seems like an incredible opportunity!

submitted 19 days ago • 0 comments

Heading to #lornegenome25 #LorneCancerConference ? Looking for a computational postdoc to work on spatial and single nuclei transcriptomics of poor prognosis cancers, please DM me or see me at Lorne. We will be advertising soon. @ozsinglecell.bsky.social #LorneCancer2025 #Lorne2025

submitted 20 days ago • 1 comment

Our new paper examining how to analyse longread RNA-seq with no reference genome. We compare approaches for assembly and downstream analysis, from transcript accuracy to differential expression. Lead by @alexyfyf.bsky.social. Thnx to all contributors incl. @qgouil.bsky.social for the pea data!

submitted 22 days ago • 1 comment

This is not my normal field but it was written by my husband- he is meant to be promoting it but doesn't do social media so you have to make do with me instead 😄 Cohesin as an essential disruptor of chromosome organization: Molecular Cell www.cell.com/molecular-ce...

submitted 27 days ago • 1 comment

Thanks @immunolcellbiol.bsky.social for inviting Menno and I to write this commentary about the @bogunoviclab.bsky.social paper in @nature.com on monoallelic allele expression in inborn errors of immunity Monash Immunology and Erasmus MC #immunosky doi.org/10.1111/imcb...

submitted 26 days ago • 1 comment

We're #hiring a #postdoc to join our lab 🧪 in Melbourne 🇦🇺🦘 in #StemCell and #Cancer #Epigenetics. Great opportunity to lead a research project within the broader vision of the lab, with plenty of scope to develop as an independent leader 👩‍🔬🔬 Apply by 27 Feb careers.petermac.org/job/MELBOURN...

submitted 32 days ago • 0 comments

Go TADs! Very nice and elegant study showing enhancer-promoter connectivity within TADs genesdev.cshlp.org/content/earl...

submitted 34 days ago • 0 comments

Hear, hear! The Universtiy Medical Center Goettingen is inviting applications to its new Medical Scientist Program “Genomic responses to disease plasticity” funded by the EKF Stiftung. The program will support early-career bioscientists with a PhD eager to do clinically-oriented research... 1/n

submitted 36 days ago • 1 comment

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

submitted 37 days ago • 6 comments

Welcome to UC Irvine! We are really happy to have you join our department. To everyone else - it’s an amazing opportunity to study gene regulation and neural crest development in sunny Southern California!

submitted 42 days ago • 1 comment

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

submitted 47 days ago • 6 comments

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

submitted 46 days ago • 2 comments

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

submitted 46 days ago • 1 comment

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs: www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... Dimitra and I had the pleasure to write a Preview: www.sciencedirect.com/science/arti...

submitted 46 days ago • 0 comments

A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 46 days ago • 0 comments

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

submitted 47 days ago • 3 comments

Please see 🧵by @evhealy.bsky.social about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇

submitted 48 days ago • 0 comments

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

submitted 48 days ago • 3 comments

our newest preprint! Led by Zoe Grant in my lab and Shuzen Kuang in Katie Pollard's lab here at Gladstone. "Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor" 1/n www.biorxiv.org/content/10.1...

submitted 49 days ago • 5 comments

The single best career advice that I give PhDs is that there are multiple different pathways to success. It is the detours that make your insights unique. This is why @immunolcellbiol.bsky.social made #PathwaysToSuccess - get inspired from different journeys! onlinelibrary.wiley.com/page/journal...

submitted 50 days ago • 1 comment

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

submitted 73 days ago • 15 comments

"unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression." #ImmunoSky

submitted 53 days ago • 1 comment

Now for something a little different: our work on craniofacial development in new born fat tailed dunnarts, a tiny bitey carnivorous marsupial, is now out on eLife, and you can read it and the reviews while we work on the revisions :) elifesciences.org/reviewed-pre...

submitted 54 days ago • 0 comments

As a first #ImmunoSky post, I’m excited to share our latest pre-print, by the fantastic Mitchell Zheng! www.biorxiv.org/content/10.1... Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. 🧵 1/9

submitted 74 days ago • 4 comments

Superb work by Wouter @Zouters & @OlgaPushkarev developing ChromatinHD, two scale-adaptive #machinelearning models & interpretation tools that use #scRNAseq + #scATACseq data to better understand how chromatin accessibility relates to gene expression doi.org/10.1038/s414... Happy 2025 everyone 🎆 !

submitted 57 days ago • 1 comment

How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n

submitted 56 days ago • 4 comments

Delighted to share a 🧵on our recent papers: 1. Allergen-specific IgE as the main predictor of remission following 🥜 #peanut oral immunotherapy (#OIT) in kids. Younger age association primarily driven by ⏬lower levels of IgE in younger children (1/6)

submitted 57 days ago • 1 comment

A good start into 2025: www.cell.com/cell-reports.... High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo.

submitted 57 days ago • 4 comments