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rmgiadone.bsky.social
“Aging postdoc” using stem cells, organoids, and parabiosis to study the aging brain with Lee Rubin in the Dept. of Stem Cell and Regenerative Biology @Harvard CReM of BUSM and UMass Lowell alum, first gen college goer
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“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. AI co-scientist is a collaborative tool to help experts gather research and refine their work” blog.google/feed/google-...

A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations. @itamarchinn.bsky.social @pgmikhael.bsky.social www.science.org/doi/10.1126/...

wHy WoUlD aNyOnE nOt WaNt To WoRk In AcAdEmIa???//

www.nature.com/articles/s41...

New year, new lab! I’m excited to announce the opening of the Herriges lab at the Center for Regenerative Medicine of Boston University and @bupulmonary.bsky.social. Thank you to everyone at BU and in the wider pulmonary research community that has supported me throughout my career.

Absolutely GUTTED RIP to the 🐐🐐🐐

Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation www.science.org/doi/10.1126/...

An extensive review of clinical trials based on pluripotent stem-cell-derived cells. A true masterpiece in the making! 📊 116 clinical trials 🔬 83 hPSC products 👩‍⚕️ 1,200+ patients www.cell.com/cell-stem-ce...

Disagreement on foundational principles of biological aging academic.oup.com/pnasnexus/ar...

He is not a toy He is not a Christmas present He is a 30 year commitment

99% of the circulating cells, 84% of the cells in the body are RBCs. These 25 trillion cells shed 1 vesicle/h (more under stress). With >250 transporters and receptors, RBCs pick up/release metabolites, at times even against gradient, throughout the body. Yet, they are not part of 👇 conversation

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Think carefully before buying a Greenland shark for the holidays. They are, after all, the world’s longest-living vertebrate.

The deacetylase SIRT6 reduces amyloid pathology and supports cognition in mice by reducing the stability of APP in neurons 👨‍🔬Suggesting that "activating SIRT6 has therapeutic potential to reduce amyloid-associated pathology in patients with AD." www.science.org/doi/10.1126/...

Just came over here to take a peek and already found this warm welcome!!

Ageing of stem cells reduces their capacity to form tumours #Nature @natureportfolio.bsky.social "Most human cancers initiate at a young age, highlighting the importance of directing cancer prevention efforts towards young individuals." www.nature.com/articles/s41...

“ ‘When someone seeks,’ said Siddhartha, ‘then it easily happens that his eyes see only the thing that he seeks, and he is able to find nothing, to take in nothing. [...] Seeking means: having a goal. But finding means: being free, being open, having no goal.’ ” Hermann Hesse

Wow, wow, wow. Lovely work from Shigeki’s lab demonstrating morphological features of axons which have been a matter of some debate that are going to be important for modeling and understanding neuronal homeostasis and function.

The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity https://www.biorxiv.org/content/10.1101/2024.12.01.626216v1

Post an Onion headline that lives in your head rent free Biologist Completes 5-Minute Study Of Pathetic Organism In Mirror theonion.com/biologist-co...

Arise, UPR & ISR scientists ! I will have missed many, so please tag below go.bsky.app/8VzRKLW

Grateful for the opportunity to collaborate with @drgjmurphy.bsky.social on this project! A library of #centenarian iPSCs for #aging studies - an *open source* bank at the CReM of @bostonu.bsky.social

Work on something that everyone in the field has agreed about, but which your intuition tells you is wrong. – Geoffrey Hinton

A @science.org First Release: @tommyz626.bsky.social, Wei Zhou, @junyuecao.bsky.social & colleagues present #PanSci, a #SingleCell #atlas profiling >20 million cells from 623 #mouse tissues across various #ages & #genotypes w/ a focus on regulatory roles of #ImmuneSystem on #aging !

This is a super cool concept

2 new studies on brain aging with sex-specific findings —Angiogenesis factors www.science.org/doi/10.1126/... —Loss of gray matter press.psprings.co.uk/jnnp/novembe...

has anyone posted this here yet www.youtube.com/watch?v=aQUl...