rpdevrieslab.bsky.social
Virologist turned glycoscientist... Associate Prof @ Utrecht University Chemical Biology & Drug Discovery
28 posts
331 followers
273 following
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I like to think that this was the starting point of our recently awarded NWO-XLš. Great to see this on BioRxv now... many thanks to @uu-cbdd.bsky.social @uuuips.bsky.social
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Major work by @mriosc.bsky.social, and many thanks to @uu-cbdd.bsky.social
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Interestingly, the 2.3.4.4e HA only bound human-type receptors when the Q226L was introduced and also solely bound to human tracheal sections. Thus, the Q226L is quite context dependent!
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First, we do not observe human-type receptor binding for the 2.3.4.4b HA. The isolate used predates the current outbreak in cattle but only differs by 6 amino acids (and lacks an MBCS) outside of the receptor binding domain, compared to the A/TX/324/24 strain.
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Welcome to BSKY department! let the #glycotime commence!
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I also always wondered until i got that npj virus paper on my desk. You may question the biological relevance, but fun it is š
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www.nature.com/articles/s44...
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Enjoy!
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Many thanks to @TheBoonsGroup @UU_Glycoscience @uuuips.bsky.social @CICbioGUNE.
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We fell into a major epistasis "trap," but we figured it out. We also demonstrate that symmetrical tri-LacNAc N-glycans are not displayed in human and ferret respiratory tissues, while the asymmetric version is there.
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There were significant antigenic changes, and these often affect receptor binding. So Ruonan went on a quest to analyze which amino acids were responsible for the changes in receptor binding properties.
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Between 2000 and 2020, these viruses evolved to a strict specificity to branched polyLacNAc N-glycans, but recently, viruses regained binding to di-LacNAc structures. Regaining binding to erythrocytes is vital for antigenic analyses. doi.org/10.1021/jacs...
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I always thought that b3gnt2 is THE limiting factor? Interesting stuff here š
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As terminal GlcNAc on the outside of cells? I thought it would be more or less the same as high man
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Same! Makes me think of 2G12, an anti HIV nAb recognizing high-man, which can neutralize many other viruses.
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Could you add me? Many thanks