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sanderhouten.bsky.social
Scientist working on inborn errors of metabolism. Associate Professor at the Icahn School of Medicine at Mount Sinai. New York.
16 posts 68 followers 64 following
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Sad milestone: As of today more than half of scheduled study sections this year did not meet as scheduled. Sections not meeting as scheduled today (2/26): BCO, CIHB, HHD, LHB, MABS, PMDA, TAG, CDIN, MPPA, ZRG IIDB-F. As of now, the NIH has no new postings to the Federal Register since 01/21/25.

submitted 1 hour ago • 1 comment

I haven't been posting often on Bluesky. And the skies are not so blue these days in the US science world. One thing we can certainly do is to show that our work is important and contributes to progress in science. Two studies that my lab contributed to were posted on bioRxiv over the last 2 weeks.

submitted 2 days ago • 1 comment

I haven't been posting often on Bluesky. And the skies are not so blue these days in the US science world. One thing we can certainly do is to show that our work is important and contributes to progress in science. Two studies that my lab contributed to were posted on bioRxiv over the last 2 weeks.

submitted 2 days ago • 1 comment

A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism https://www.biorxiv.org/content/10.1101/2025.02.19.639093v1

submitted 5 days ago • 0 comments

Odd-chain dicarboxylic acid feeding recapitulates the biochemical phenotype of glutaric aciduria type-1 in mice https://www.biorxiv.org/content/10.1101/2025.02.13.637994v1

submitted 9 days ago • 0 comments

submitted 10 days ago • 0 comments

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

submitted 16 days ago • 1165 comments

There it is! The end of academic science in the US. grants.nih.gov/grants/guide...

submitted 18 days ago • 0 comments

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants. —> Deep budget cuts & program closures coming to a university near you. Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

submitted 18 days ago • 102 comments

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

submitted 18 days ago • 271 comments

Ik had een discussie met een vriend over #X en #BlueSky. Hij zit nog op X omdat hij niet gelooft in de impact en het bereik op BlueSky. Dus een weddenschap. Ik (wij) win(nen) als deze post binnen 24 uur minimaal 50x gedeeld en 100x geliked wordt. Dus ik heb jullie ff nodig. 🙏 HUP BlueSky! 💪 😊

submitted 30 days ago • 54 comments

www.theatlantic.com/science/arch...

submitted 30 days ago • 0 comments

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria

submitted 32 days ago • 19 comments

"The science of extreme longevity continues as an immense joke." —The first man to “survive” past 110 actually died at 65. —Blue zones are a myth —Pervasive false claims about longevity and supercentenarians Gift link www.nytimes.com/2025/01/20/o...

submitted 36 days ago • 26 comments

This is interesting. Second case identified of a disease caused by a mutation in ABCD3 gene (peroxisomal transporter)? pubmed.ncbi.nlm.nih.gov/39814052/

submitted 37 days ago • 1 comment

Now live - our review of neurodegeneration in lysosomal storage disease - comparing and contrasting disease mechanisms; emerging evidence of unifying convergence @jimd-editors.bsky.social @ucl-ifwh.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

submitted 39 days ago • 1 comment

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

submitted 43 days ago • 7 comments

Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)

submitted 44 days ago • 1 comment

Host metabolism balances microbial regulation of bile acid signalling www.nature.com/articles/s41...

submitted 48 days ago • 0 comments

I love a metabolic mystery and so I’m rather tickled by this new publication in Clinical Chemistry, detailing the: Diagnostic Odyssey in a Child with Red-Colored Urine and Proteinuria Brianna Guarino et al doi.org/10.1093/clin...

submitted 53 days ago • 0 comments

Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits www.nature.com/articles/s41...

submitted 54 days ago • 0 comments

NAPstars, a new genetically encoded NADP redox biosensor. Look forward to testing it. “A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes”https://www.nature.com/articles/s41467-024-55302-x

submitted 61 days ago • 1 comment

Christmas is a good time to throw Wikipedia a few bucks to thank them for the many times you relied on the site that year. Members of the billionaire class want to destroy it for some reason. (@archive.org is also under constant threat nowadays and in need of support)

submitted 63 days ago • 121 comments

This is a cool paper. A CRISPR/Cas9 loss-of-function library targeting nuclear-encoded mitochondrial genes and galactose-based screenings at various time points uncovers novel regulators of mitochondrial function www.biorxiv.org/content/10.1...

submitted 80 days ago • 0 comments

#autophagy is so hot right now! So here's an update on autophagy disorders Hormos Salimi Dafsari, et al https://doi.org/10.1002/jimd.12798

submitted 82 days ago • 0 comments

As the community grows fast, here is an updated Metabolism Starter Pack 2 with loads of exciting scientists go.bsky.app/CH1MctZ

submitted 84 days ago • 12 comments

I’m not sure why or how they picked me but it does feel like a life achievement unlocked to have been a clue on Jeopardy!

submitted 84 days ago • 18 comments

Quantification of nutrient fluxes during acute exercise in mice Wonder what happens in the brain? www.cell.com/cell-metabol...

submitted 84 days ago • 0 comments

Have you wanted to know more about philosopher Hannah Arendt, but not known where to start. Here is an excellent @britishacademy.bsky.social 10 Minute Talk from @lyndseystonebri.bsky.social which gives you some of the key concepts and why they matter today www.thebritishacademy.ac.uk/blog/hannah-...

submitted 183 days ago • 10 comments

Muri et al have previously demonstrated white matter changes in adults with early treated PKU. In new work they show that temporary exposure to high Phe levels leads to reversible white matter changes. doi.org/10.1002/jimd... #pku #phenylketonuria

submitted 88 days ago • 0 comments

Potential therapeutic uses of L-citrulline beyond genetic urea cycle disorders Keep to know more about the little Amino Acid that could? Then read on 👉 https://doi.org/10.1002/jimd.12810 #sicklecell #asthma #BPD

submitted 93 days ago • 0 comments

As the left flees and X loses broader relevance, it becomes a more overtly right-wing site, @alibreland.bsky.social writes. But the right needs liberals on X in order to push conservative perspectives into the mainstream.

submitted 95 days ago • 341 comments

Hi science friends. Let’s try this again!

submitted 94 days ago • 1 comment