seanamontgomery.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.   www.biorxiv.org/content/10.1...   With @benlehner.bsky.social [1/7]

submitted 20 hours ago • 2 comments

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

submitted 7 days ago • 12 comments

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

submitted 12 days ago • 2 comments

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14

submitted 12 days ago • 21 comments

Delighted to see our work now published in @currentbiology.bsky.social. A great place for Bostrychia to stake its claim as an emerging red algal model system. Check it out here: www.cell.com/current-biol...

submitted 23 days ago • 4 comments

Check out this tremendous work from @ianakim.bsky.social! An enormous effort to gather micro-C data from 9 species and uncover insights into how animal genome organization evolved and diversified!

submitted 26 days ago • 0 comments

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

submitted 33 days ago • 14 comments

Our preprint has now found a wonderful home in @molbioevol.bsky.social. Shout out to our collaborators in the Mozgova lab too 💚

submitted 45 days ago • 0 comments

In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology: rdcu.be/ehkWp

submitted 52 days ago • 8 comments

Excited to see all the EvoChromo people again at this meeting! A fantastic collection of kind and curious researchers made the last edition the top meeting I've attended, and I expect v2 to be even better!

submitted 53 days ago • 0 comments

Fantastic study on so many levels, check it out! DNA methylation, chromatin accessibility, developmental biology, horizontal gene transfer, and my favourite, Marchantia! This paper has it all

submitted 54 days ago • 1 comment

My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT! For more information see here: gahanlab.com tinyurl.com/34xke35d

submitted 55 days ago • 1 comment

wow, telomeric transposons in bacteria with linear chromosomes! (of course this was first figured out in flies, inc by Bob Levis, who i was happy to see few days ago at the fly meeting). 🪰 www.science.org/doi/10.1126/... www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

submitted 67 days ago • 0 comments

Interested in photosynthetic organisms? Looking for a space to focus on research and kick-start your journey as a group leader? We’d love for you to join us. We offer an incredibly competitive package—on par with about 2 ERC grants for 8 years—and a collaborative environment unlike anywhere else 1/2

submitted 67 days ago • 1 comment

Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement 🤯 #TEsky www.biorxiv.org/content/10.1...

submitted 70 days ago • 0 comments

🔬 PhD Opportunity in Evolutionary Cell Biology! Interested in how cell types evolve? Join us to investigate placozoan cell types using advanced microscopy, single-cell omics, and functional assays! Apply here: euraxess.ec.europa.eu/jobs/323665 #PhDPosition #EvolutionaryBiology #CellBiology🧪

submitted 84 days ago • 0 comments

Excited to share this story from the “Chromatin Dream Team” in the @arnausebe.bsky.social lab on chromatin evo across eukaryotes! 12 histone mark profiles from 12 species, including rhizarians, discobans, and cryptomonads. Read on to see what we found! www.biorxiv.org/content/10.1... 1/n

submitted 75 days ago • 1 comment

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

submitted 77 days ago • 11 comments

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...

submitted 80 days ago • 2 comments

After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo www.biorxiv.org/content/10.1...

submitted 81 days ago • 4 comments

We offer three new positions to join BCA Phase 0: 1. A full-stack developer to work on the BCA database with @ebi.embl.org 2. A senior research technician to develop sc methods 3. A bioinformatician to analyze new atlases with @sangerinstitute.bsky.social Details below. Please, share and repost.

submitted 91 days ago • 1 comment

🚨Preprint Alert🚨 I'm really happy to finally share our exploits in red algae and introduce the wider community to Bostrychia, the new model system we have been developing to tackle the molecular biology of red algae. Isn't she a beauty? Thread below 🧵 1/8 www.biorxiv.org/content/10.1...

submitted 111 days ago • 4 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

submitted 115 days ago • 3 comments

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

submitted 150 days ago • 1 comment

Intriguing work on an H3K27me3-reader protein leading to transcriptional activation: www.embopress.org/doi/full/10.... Ciliates continue to impress! The authors also draw nice parallels to Rhino (H3K9me3 reader) and piRNA cluster expression in Drosophila

submitted 177 days ago • 0 comments

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

submitted 182 days ago • 14 comments

The yeast genome is globally accessible in living cells [new from the group of David Clark] www.nature.com/articles/s41... ▶️Measured DNA accessibility in living budding yeast by inducible expression of methyltransferases ▶️The genome is globally accessible in living cells, unlike in isolated nuclei

submitted 186 days ago • 6 comments

behold our paper on Medusavirus nucleosomes. Fantastic work by Chelsea Toner, @nhoitsma.bsky.social, and Sashi Weerawarana This giant virus also encodes a linker histone, more about that in the paper 🧪👩‍🔬 🧵. www.nature.com/articles/s41...

submitted 222 days ago • 5 comments

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

submitted 188 days ago • 9 comments

Check out the lab website for more details on what we do! www.sebepedroslab.org

submitted 189 days ago • 0 comments

For my first post here, I am happy to share that our latest paper is out at #NAR. Thanks for the smooth and constructive reviewing process and the highlight #RNAbiology #TEsky #smallRNAs (1/8) doi.org/10.1093/nar/...

submitted 189 days ago • 6 comments

Very nice to see this work on silencers from the Stark lab! doi.org/10.1016/j.mo...

submitted 193 days ago • 0 comments

Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025

submitted 194 days ago • 2 comments

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ

submitted 201 days ago • 7 comments