sebatlab.bsky.social
Psychiatric genetics, complex trait genetics, genome sequencing, rare variants are my jam
121 posts
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Congrats! What proportion of pQTLs were clearly an aggregate burden of multiple independent variants? And what proportion were basically a single low frequency haplotype?
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The silver lining is the U.S. is utterly alone in abruptly reversing its position. Europe continues to fight for Ukraine.
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I forgot how much fun it is to argue with techbro trolls
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If he admits that he was wrong, then he was clearly not the typical true believer. But yeah, he could have figured it out sooner
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If you are wondering “how is this possible?”. Officially it’s not, so this is obviously an attempt to squeeze Universities and get some quick leverage over them
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I wonder how many grant proposals have an emoji for panel B
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I need to read this paper more carefully but I didn’t see how they distinguish between “early life contingency” and the subset of animals that carry a rare coding variant (which almost certainly exist)
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They are less identical than that because they are dizygotic, and will also carry heterozygosity from the lab’s line
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@abepalmer.bsky.social may have some thoughts
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Narrator: No inbred mice are "genetically identical"
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It genuinely makes me …. inwardly scream …. when I see/hear of/read of someone doing case/control epigenome wide association
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LOL
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Choose your weapon
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They are definitely sending a message. “So you like that cookie huh? Good because it’s all you’re gonna find across this 836,000 square miles”
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It’s called the molusc O’keeffe
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I still think the differential indications are a concern. Bipolar will correlate with higher SES in some cohorts. Other drugs will correlate with lower education and SES as you point out. Need better data on siblings
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The sibling point estimate for association of valproate with autism is was 1. Yes it was underpowered so not particularly informative. If these cohorts are independent of the cohorts that gave original negative results for Lamotrigne, that’s stronger. Were they?
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I'm curious how Lamotrigne became the comparison group. Lamotrigne is used in bipolar disorder. IF many in this group are being treated for bipolar, I would not consider it a representative sample of people that are getting a safe drug. Not sure I consider it a conservative control group either.