shazanfar.bsky.social
14 posts
1,023 followers
412 following
Regular Contributor
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:D Thanks Matt!
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Thanks Jovana!! :D
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Thanks so much Davis!!
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Thanks Tim!!
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Thank you Dana!!
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Thank you Bertie!
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I want to thank all the coauthors including @boyiguo.bsky.social, Caleb Hallinan, and most importantly, my partner in crime who co-led this work with me @shazanfar.bsky.social 😀
Finally, we want to thank @cziscience.bsky.social for the generous funding and support!
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The preprint is available on @biorxivpreprint.bsky.social and we would welcome feedback
📖 doi.org/10.1101/2024...
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Using simulated data, we show how spatialMNN can identify spatial domains across N=64 tissue sections with less than 5Gb memory (RAM) in under 10 mins! 🔥
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Using mouse Alzheimer's Disease tissue sections profiling genes and proteins on STARmap PLUS, we found spatialMNN is able to find disease-related niches (unsupervised clusters using gene expression) where the Abeta protein accumulates (dark blue dots)
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It's designed for barcode- or imaged-based spatial technologies and we compare the performance (accuracy, memory, and speed) of spatialMNN to other existing spatial clustering algorithms and find it's fast, memory-efficient, and accurate! 💃
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Biology is *spatiotemporal*
Processes such as cancer, wound healing, & embryonic development occur in both time AND space.
@shazanfar.bsky.social 5/
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They are specially evolved with a long beak to poke through rubbish bags and to reach into bins from the edge 🤣🤣 interestingly they honk like geese!!
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Thank you Andreas!!
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This is great Andreas! Could you please add me? Thanks :)