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steveroyle.bsky.social
I'm into chord changes and cell biology. Professor at University of Warwick. Director of The Company of Biologists. Affiliate of bioRxiv. Author of "The Digital Cell". Views my own. Mastodon: @[email protected] Lab: https://roylelab.org
207 posts 2,818 followers 1,136 following
Prolific Poster

Do not miss the #membrane seminars this THU! As usual zoom link and info here felixcampelo.wixsite.com/membranetraf... or via the mailing list lists.icfo.es/mailman/list... @felixmendu.bsky.social @ishier.bsky.social

Hi @bsky.app @support.bsky.team love your work and all but can you come out in support of the mental health of your many users and introduce the ability to turn off retweets for people you follow? People reading this, RT if you also want to see this feature introduced ASAP.

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

BIG news: Jason Chin is leaving the Division of Protein & Nucleic Acid Chemistry of @mrclmb.bsky.social to spend yet another billionaire's ££ in Oxford. This will create a gap that will need filling! So, if you're thinking of making a move, now is the time to reach out! www.eit.org/news/profess...

Two faculty positions in Computational Biology in Cambridge - one of them jointly with @geneticscam.bsky.social.

🚨Long term postdoc position available on the reconstitution of lipid kinases!🚨 Do you have a passion for protein reconstitution and lipid signalling? You will reconstitute lipid kinases from eukaryotic expression systems to determine their kinetic regulation. www.jobs.ac.uk/job/DLW981/r...

🔎 Looking to start a PhD in Sept 2025? The Crick Institute spring round for PhD recruitment is open! If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT www.crick.ac.uk/careers-stud...

We are featuring Michael Way, current Editor-in-Chief of @jcellsci.bsky.social and Principal Group Leader at @crick.ac.uk, as our next extraordinary biologist this week. To know more about JCS and Michael's role, read this Editorial: bit.ly/3CUARU1. #100biologists @drmichaelway.bsky.social

As part of @biologists.bsky.social 100-year anniversary, it has been fun to look at the older journal content. For this post, I went all the way back to 1853 to look at early efforts at segmentation, wise words on peer review and the benefits of sharing tips and tricks rather than whole stories.

The Warwick Integrated Structural Biology Centre Opening Symposium will be taking place on 27th March 2025 warwick.ac.uk/fac/sci/dept.... Offered talks are welcome – please submit an abstract by this Friday 21st Feb if you want to speak. Registration details are here: warwick.ac.uk/fac/sci/dept...

Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n

Are you a budding science writer? ✍️ Then enter our science writing competition. Entries can be fiction or non-fiction. Find out more here: bscb.org/competitions... Deadline 1st March

“Lab Girl” being censored is baffling. I’ve read this wonderful work; nothing offensive in it whatsoever — unless showing that women can be scientists is no longer “appropriate content” for children?? Everyone go buy a copy in protest. My 2016 review in Nature👇 www.nature.com/articles/532...

Not long until the deadline for this faculty position @dunnschool.bsky.social... Are you the one to lead a group doing great research in a special environment, while teaching outstanding students? www.path.ox.ac.uk/vacancy/asso...

Do you want one of the most influential jobs in dev bio? Would you like to work with the best group of editors & publishing professionals in the business? Are you interested in leading the premier not for profit community focussed journal in the field? Come be Development's next Executive Editor

Dishonest charts are coming from all directions, and they're only going to hit harder. Unless we push back. So, an interactive guide: Defense Against Dishonest Charts flowingdata.com/projects/dis...

Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

💥 Quick thread on some stunning actin filament swirls🌪️ spotted under platinum replica EM, often forming nest-like structures around caveolae🏐 #ActinAesthetics #ElectronMicroscopy

Did you know… It’s free to publish in JCS – there are no submission charges, membership fees, page charges, or colour charges. For details on this and other reasons to choose JCS, visit our website: journals.biologists.com/jcs/pages/re...

'For example, whereas more than 13,000 research articles have been published on TP53, half of human genes are barely mentioned in the literature (Fig. 1). It is estimated that 75% of all research on protein-coding genes has been focused on fewer than 10% of proteins' www.nature.com/articles/s41...

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

Over 300 signatures so far, listed here: occamstypewriter.org/scurry/2025/... - please keep signing and sharing.

I’m so grateful for all my wonderful colleagues in the Molecular Cell Biology of Autophagy Lab, who inspire, challenge and support me every day. Together we’re making an impact, breaking barriers and shaping the future of science #womeninSTEM #internationaldayofwomanandgirlsinscience

Don't forget to sign up for the Microtubule meeting UK on the 12th May, the registration just got cheaper, thanks to our sponsors! Lots of slots for talks and posters!

New preprint from the MemTraS team ! www.biorxiv.org/content/10.1... Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.

New blog post: Exploring the bioRxiv API with R, httr2, rvest, tidytext, and Datawrapper doi.org/10.59350/wzt... #Rstats

On my way to #bps2025 @biophysicalsoc.bsky.social I’m biking from SF to LA to promote low-emission transportation and raise money for World Bicycle Relief. Donations: 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten

Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify

Weekend reading: three nice preprints published yesterday. First is @mkiwanski.bsky.social et al. in Lucas Kapitein's lab using Motor-PAINT and expansion microscopy to visualize micotubule orientation in developing neurons: www.biorxiv.org/content/10.1...

Happy to share our paper’s final version on the evolution, structure, and membrane binding / remodeling of Asgard ESCRT-III proteins! And my first 🦋 post! www.science.org/doi/10.1126/...

Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards… What would you do with this? Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵

Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...

Heads up Early Career Researchers! You can apply for a funded place at the upcoming @biologists.bsky.social Workshop "Democratising Microscopy in Latin America: Imaging Across Scales and Regions". Deadline 14th Feb! www.biologists.com/workshops/gl...

We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !

Being critical is not the opposite of being optimistic. Its the opposite of not being critical. Optimism is a feeling, critical thinking is a process. A process that lets you see through the BS. Including the BS created by your feelings.

We invite you to submit your latest research to our special issue - Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social. journals.biologists.com/jcs/pages/ci...

Answering the call of @haesleinhuepf.bsky.social, Christian Tischer, Pete Bankhead, @kbias.bsky.social @bethcimini.bsky.social My Fiji training notes are now FAIR. All online in an open format to download and use for teaching and training. All in Google Doc or PDF formats bit.ly/4hkfEBF

Did you know that @biologists.bsky.social has a whole subject collection dedicated to articles discussing EDI topics such as this one?

📢 Submissions are now open for the CellMap Segmentation Challenge. Build the best method for segmenting cellular organelles in vEM using our 289 annotated volumes, 40 organelle classes, and 22 diverse cell and tissue types. 🔗 hhmi.news/410evJQ

Two new lab manuscripts describing new insight into VPS29’s role in Retromer vs Retriever, and the identification of a non-classical Commander pathway in melanosome biogenesis. Both with @BrettCollins.bsky.social lab. www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1...

Read this interview with Sarah Bray (@uniofcam.bsky.social) to learn more about her early association with @biologists.bsky.social, her responsibilities as the Chair of the Company's Board, and the Company's 100-year anniversary celebrations: journals.biologists.com/dev/article/...

Link: doi.org/10.1101/2025...