sudhirthakurela.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature perception can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

submitted 82 days ago • 37 comments

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O

submitted 97 days ago • 0 comments

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

submitted 91 days ago • 9 comments

Congratulations Dr. Chandrashekar 💐 Using human neurons homozygously-engineered with familial AD mutations, Harshini found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs doi.org/10.1101/2024...

submitted 93 days ago • 1 comment

How do cells remember transient signals? New work reveals that a transient pulse of histone deacetylase inhibition leaves a lasting mark on 3D genome architecture in mESCs, linking chromatin dynamics to cellular memory and gene expression robustness. www.biorxiv.org/content/10.1...

submitted 93 days ago • 2 comments

First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 : scidraw.io bioart.niaid.nih.gov www.phylopic.org More well known but very nice though: www.freepik.com

submitted 95 days ago • 59 comments

Pearl millet bread with ghee, with bottle gourd raita and sabji! The diversity of food options in India is at another level. #IndianFood #FoodDiversity

submitted 94 days ago • 0 comments

A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping www.nature.com/articles/s41...

submitted 95 days ago • 0 comments

Here is a #compbio starter kit! go.bsky.app/QVPoZXp To all the #Bioinformatics #Genomics #MachineLearning folks: please RP and let’s build this together!

submitted 95 days ago • 41 comments

It is so disappointing & disheartening to see that the grant was withdrawn stating that it is out of scope 😢. Developmemtal signaling, transcription network and chromosome structure, and epigenetic gene regulation are well within NIGMS stated scope. Any suggestions from experienced folks here?

submitted 95 days ago • 2 comments

Beautiful paper out today: “Intrinsic GATA4 expression sensitizes the aortic root to dilation in Loeys–Dietz” points to key developmental TFs specific to vascular segments impacting disease risk, implies a link between developmental programming and genetic disease www.nature.com/articles/s44...

submitted 96 days ago • 0 comments

www.cell.com/molecular-ce...

submitted 97 days ago • 0 comments

cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers. www.nature.com/articles/s41...

submitted 98 days ago • 1 comment

Hey, a question for the genetics community. Does genetic fine-mapping work well? How often does it miss? We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!

submitted 98 days ago • 9 comments

My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body. If you are interested in doing a Ph.D. with me at UMass Chan Medical (Genomics and Comp Bio Department), see the links below. Deadline is Dec 1st.

submitted 100 days ago • 7 comments

🚨Preprint alert! tinyurl.com/2zkmynsd Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays? Then Spatial-scERA is the method for you! #spatialOMICs

submitted 100 days ago • 2 comments

💫 Join us! We are looking for an enthusiastic #postdoc! Are you excited about #epigenetics, #neocortex development, neurodevelopmental #disorders, #evolution, #organoids? Apply until 27 Nov 2024! 4-year fully funded position tu-dresden.de/vacancy/11767

submitted 99 days ago • 0 comments

Latest publication from our lab! The project started during the pandemic! Was led by –the fabulous– Karen Cornejo (graduating in 2025). Also, awesome contributions from all authors, specially, Andie Venegas and @dykhuizenlab.bsky.social. This one is special! www.sciencedirect.com/science/arti...

submitted 100 days ago • 0 comments

Excited to see the second edition of this book on Transcriptional Regulation by Neuronal Activity (edited by Ramendra Saha and @serenadudette.bsky.social) officially published! Lots of great content here, may be useful for people new to this field. link.springer.com/book/10.1007...

submitted 101 days ago • 1 comment

Use this to search the starter pack directory and find areas of interests. #AcademicSky 🧪 #science blueskydirectory.com/starter-pack...

submitted 101 days ago • 1 comment

We are super happy to see our manuscript finally online! academic.oup.com/nargab/artic...

submitted 102 days ago • 2 comments

Delighted to share our work to develop a genomic DNN, Enformer Celltyping, to accurately predict epigenetic signals in previously unseen cell types has now been published doi.org/10.1038/s414...

submitted 100 days ago • 1 comment

Interesting, E-life has introduced new article formats including a short report format: elifesciences.org/inside-elife...

submitted 100 days ago • 0 comments

starter pack 2 for all things #chromatin, #transcription, and adjacent: go.bsky.app/Q5sXc6E - reply to self-nominate or suggest colleagues! check out pack 1: go.bsky.app/5zgpZfg and @sproullab.bsky.social's pack: go.bsky.app/TKp9YAn for more people to follow

submitted 105 days ago • 25 comments

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

submitted 107 days ago • 47 comments

Hi everyone on Bluesky! I’m Stelios, and I’m a senior editor at Nature Cell Biology. I handle #stemcell, #DevelopmentalBiology, #disease, and (pre)clinical papers at the journal. I will be posting relevant content (and not only) here and I’m looking forward to interacting with you all!

submitted 103 days ago • 3 comments

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

submitted 101 days ago • 12 comments

#RECOMB2025 will be in Seoul on April 26-29, 2025. Satellites on April 24-25, 2025. Save the date! #RECOMB2025 가 2025년 4월 26-29일에 서울에서 개최될 예정입니다. Satellites는 2025년 4월 24-25일에 있을 예정입니다. 날짜를 비워두세요!

submitted 101 days ago • 0 comments

EpiSci - www.cell.com/molecular-ce...

submitted 101 days ago • 0 comments

Assembloids have emerged as a powerful tool for studying previously inaccessible processes of development and tissue homeostasis. In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.

submitted 101 days ago • 1 comment

(1/8) 🚀 Excited to share our findings on a large-scale ChIP-seq assay for 166 previously uncharacterized human transcription factors (TFs) and their roles in both regulatory regions, and more strikingly, the “dark matter” genome. 🌌 doi.org/10.1101/2024....

submitted 103 days ago • 3 comments

go.bsky.app/SxcKi5z

submitted 102 days ago • 39 comments

www.cell.com/cell/fulltex... The chromosome folding problem and how cells solve it Great review by @jobdekker.bsky.social & Leonid Mirny

submitted 102 days ago • 1 comment

Haven't posted on here the news! I'm the new director of the UCSD Verge Center, a $12.5 million center focused on the many genes that we are finding in schizophrenia and autism. Our center will study how these genes regulate fetal brain development and influence mental health.

submitted 105 days ago • 10 comments

So, when one of the reviewers says that everything is known about these proteins & nothing new can be discovered by this proposal, can we safely assume that we will never see another paper with these proteins 😀.

submitted 103 days ago • 0 comments

SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6

submitted 104 days ago • 13 comments