tajfisher.bsky.social
Ph.D. student in Neuroscience at McGill University
Birds, cats, brains
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147 following
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in old age cause some dysregulation of amyloid production and clearance allowing it to accumulate and start causing damage.
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but once they have formed they wreak havoc. Clearing plaques doesn't prevent Alzheimer's anymore than cleaning up the accident scene stops the train crash. My take is that several insults over the course of a life i.e. cholesterol, TBI, hypertension, chronic inflammation, infection, etc. /
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Plaques seem to be the aftermath of the disease. One way to think about it is the oligomers are cutting the brakes on an out of control train going downhill, while the plaques are the accident scene after the crash. We don't know why too many oligomers start to form and can't be controlled, but /
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Hey, I'm working on this for my PhD right now. So, yes amyloid is definitely still important. The main distinction is amyloid plaques, non-soluble, vs amyloid oligomers, smaller soluble assemblies of amyloid-Beta protein. Best evidence suggests ABeta42 oligomers are toxic, especially at synapses. /
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Whats that saying, "historic facts appear twice: first as tragedy, second as farce" Marx was wrong because both times are tragedy, but the second time nowadays seem to be so fucking cringey but still just as tragic. I guess he didn't forsee the Spectacle consuming all
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Well, for the top half of the picture. Yeesh, there's a lot going on here
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For B, it looks like they just took the green channel from the first image, duplicated it and turned up the gain and put it as the green channel in the second image too
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But, hey, I get it. Being a scientist is sexy and dangerous right now, and being a lawyer is boring and stuffy. If I were a lawyer, I might also try and do some science stolen valor
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Other health care systems largely don't make those decisions based on personal financial gain. Regardless, it's just the pearl-clutching of it all from journalists in response to this that gets me
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gun lobbies influence America's homicide rate, and just equate them
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I agree murder is wrong and social murder is not acceptable.
It is dishonest to lump delusional ideology i.e. anti-vax & climate change denial, together with ideological stances that deal with reality i.e. health insurance companies do kill people with their policy decisions &
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#neuroskyence
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Looks like the B actin bands are the same between figures and then they again duplicated 2 of the bands for last 2 lanes
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Crazy they don't even try that hard to fabricate images. Just the audacity of it all