trubianojason.bsky.social
Prof/Director of Infectious Diseases & Immunology @austin_health. UoM Research Fellow @ID_austin @CAAR_Aus @TheDohertyInst @UniMelbMDHS #AMS #AMR #penicillinallergy #drugallergy #TID
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Loved this ❤️ Talk of the #drugallergy town!
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What a great Forbes Fellow you have been! Thanks for coming to visit us ❤️
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Correct!
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PROSPECTOR 2 is going to be our international multicentre superiority study of single dose vs. multi dose challenge, informed by the pilot RCT of PROSPECTOR 1. We hope the findings from both these studies answer the controversial question once and for all.... Is one dose enough!?
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Many honourable mentions too many to mention! Didn't make the list because technically an antiviral, but abacavir HLA-B*57:01 changed the face of preventive medicine in #ID #HIV forever...
www.nejm.org/doi/10.1056/...
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My Top 5 Antibiotic Allergy Papers - #1
The birth of RCTs in penicillin allergy. Inspiration for #PALACE #PENFAST
▶️Mustafa et al. JACI In Pract 2019
💠159 low-risk pen allergy RCT 1:1 - skin testing vs. DOC
💠No significant differences. Unpowered but informative
www.jaci-inpractice.org/article/S221...
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My Top 5 Antibiotic Allergy Papers - #2
The start of the oral challenge era. Mighty paper... years ahead of its time!
▶️Mill et al. JAMA Paed 2016
💠816 👶 - 94% negative on penicillin DOC
💠DOC in anaphylaxis, no SCAR
💠High degree of follow up & toleratance pen post
jamanetwork.com/journals/jam...
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My Top 5 Antibiotic Allergy Papers - #3
Cheating.... best cross-reactivity
▶️Strom. NEJM 2003
❌ cross-reactivity b/w antibiotic- & non-anti "sulfurs"
www.nejm.org/doi/10.1056/...
▶️Picard. JACI In Prac 2019
Meta-analysis, 2% cross-reactivity. All great Romano📜
www.jaci-inpractice.org/article/S221...
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My Top 5 Antibiotic Allergy Papers - #4
▶️Bourke et al. JACI In Pract 2015; 3(3): 365
▶️The modern beta-lactam allergy clinic. Built our service on this!
▶️ NPV (skin testing & OC) - 99.2% [all risk]
▶️ Algorithms, cross-reactivity, sensitisation/time. HAD IT ALL!
www.jaci-inpractice.org/article/S221...
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Maybe will self indulge with the next Top 5 🤣
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Friday afternoon special!