trujillolab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... #PlantScience

submitted 1 day ago • 1 comment

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!! www.science.org/doi/10.1126/...

submitted 3 days ago • 0 comments

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

submitted 7 days ago • 16 comments

The next frontier in #autophagy is understanding how it functions across cell types to maintain organismal homeostasis. w/ @moritznowack.bsky.social lab, we present TWO #preprint on cell type spec. autophagy in root hairs‼️ #plantscience www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

submitted 12 days ago • 3 comments

Back-to-back on bioRxiv by @plantophagy.bsky.social and @moritznowack.bsky.social Cell-type specific upregulation of autophagy in Arabidopsis root hair cells promotes 1) root hair lifespan by suppressing cell death 2) plant salt stress resilience by ion sequestration See links to 2 papers below!

submitted 12 days ago • 2 comments

#PlantSciJobs #PlantSciJob 10 PhD positions: Communication + Dynamics of Plant Cell Compartments Research Training Group @unihalle.bsky.social and @ipbhalle.bsky.social Start: July 2025 Deadline: 31 March 2025 www.deutsche-botanische-gesellschaft.de/en/job-openi...

submitted 13 days ago • 0 comments

Yeii! nice to see our molecular pharming manuscript in its final form. Congrats to all authors!

submitted 17 days ago • 0 comments

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis www.nature.com/articles/s41...

submitted 18 days ago • 0 comments

Vector-borne viral pathogens are threats to crops, and so trigger plant immune responses. Studying rice, authors @nature provide molecular-level insights into the first steps of plant antiviral response. www.nature.com/articles/s41...

submitted 18 days ago • 0 comments

Yesterday we have just submitted our manuscript - you can find an updated version of our #preprint led by @manuelgonzalezfuen.bsky.social "Bacteria use processing body condensates to attenuate host translation during infection" with some new data on #bioRxiv 🤓 👇 www.biorxiv.org/content/10.1...

submitted 20 days ago • 0 comments

We are looking for a postdoc to study the impact of interspecific variation of ELF3 at the #mlu-halle within the EU-funded research consortium #ValuePlant. www.verwaltung.uni-halle.de/dezern3/Auss... Please share within your networks!

submitted 20 days ago • 0 comments

For all of you who cannot access pubmed, here is a good alternative: europepmc.org

submitted 29 days ago • 8 comments

Validated in 3 fungal species including Magnaporthe, the causal agent of rice blast that destroys enough rice to feed more than 60 million people every year.

submitted 31 days ago • 0 comments

🍾Big Congratulations to my dear colleague Uli Schaffrath @rwth.bsky.social and collaborators! Beautiful work showing that plant pathogenic fungi hijack phosphate signaling with conserved enzymatic effectors www.science.org/doi/10.1126/... #PlantSci #effectors #immunity #MolPlantPhys

submitted 31 days ago • 1 comment

Yes, that's a proteasome! Guess where it is....in the apoplast! Nice to see Richard Vierstra's work out! #PPStasis #proteostasis #proteasomes #PlantSci www.nature.com/articles/s41...

submitted 41 days ago • 0 comments

DELLA family proteins function beyond the GA pathway #plantscience

submitted 41 days ago • 0 comments

Our latest BioRxiv by @cmzammit.bsky.social, Cory Nadel, @pottslab.bsky.social on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to @amgen.bsky.social, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!

submitted 42 days ago • 0 comments

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

submitted 43 days ago • 0 comments

‘The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance’ www.cell.com/immunity/abs...

submitted 42 days ago • 0 comments

Really cool work identifying RIOK3 as a Ubiquitin-binding factor for 40S ribosome degradation: www.cell.com/molecular-ce...

submitted 44 days ago • 0 comments

🚨 The #Ubiquitin Congress is back in Würzburg! 🚨 Excited to host it again, June 2-4, 2025! 🌟 ✨ Still time to submit your abstract for a Short Talk! 🗓️ Registration Deadline: March 1st 📝 Abstract Submission Deadline: April 15th Don’t miss out—register now! ➡️ www.ubiquitin-wuerzburg-2025.de

submitted 63 days ago • 0 comments

Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/

submitted 63 days ago • 0 comments

Context is everything! (N-) #degron specificity of a #ubiquitin ligase reprogrammed under #proteotoxic stress. Interesting implications for biology, drug design and how we assess E3 specificity....

submitted 49 days ago • 0 comments

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work. #1 www.nature.com/articles/s41...

submitted 393 days ago • 5 comments

Deep learning for proteins tutorial: github.com/Graylab/DL4P...

submitted 93 days ago • 1 comment

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

submitted 47 days ago • 5 comments

Open call for DAAD funded PhD students of our graduate school of biology and medicine @uni-freiburg.de Please apply, if you are interested in joining us or one of our fantastic colleagues! www.daad.de/en/studying-...

submitted 52 days ago • 0 comments

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage. Check it out here: www.nature.com/articles/s41...

submitted 52 days ago • 2 comments

Happy to see that our Cell wall integrity #CWI & #ATG8ylation #preprint found a home @natureplants www.nature.com/articles/s41... Congrats Jose, Peng, Alessia & everyone involved. Stay tuned for exciting updates on this story…

submitted 52 days ago • 8 comments

Cool model of polyubiquitin chain length dictating ribosome stall resolution rdcu.be/d8iMr #ribosome #RQC

submitted 57 days ago • 0 comments

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

submitted 60 days ago • 2 comments

New in @plantphys.bsky.social - Destined for destruction: The role of methionine aminopeptidases and plant cysteine oxidases in N-degron formation academic.oup.com/plphys/article… from @emilyflashman.bsky.social @oscarlorenzos.bsky.social et al

submitted 59 days ago • 0 comments

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

submitted 61 days ago • 3 comments

On the degradation of damaged cellular proteins via C-terminal amidation. By Alfred Freeberg & @micharapelab.bsky.social. @ispt-proteinterm.bsky.social www.nature.com/articles/d41...

submitted 61 days ago • 0 comments

IS-MPMI 2025 abstract submission is open! Submit to our concurrent session "Spatial & Temporal Resolution of the Interaction Interface" if your research explores heterogeneity or spatiotemporal dynamics in plant-microbe interactions. Due March 11. See you in Cologne! www.ismpmi.org/Events/2025C...

submitted 62 days ago • 2 comments

Our latest story: a protein-protein interaction between an E3 ubiquitin ligase and an autophagy adaptor affects liquid-liquid phase separation and sequestration of a key mediator of antioxidant signaling — but not via ubiquitination! Bravo to Lin Luan and Xiaofu Cao! doi.org/10.1101/2025...

submitted 65 days ago • 0 comments

POSTDOC POSITION AVAILABLE, Geneva, Switzerland - Applications are invited for a postdoc position to study UV-B perception and signalling in plants. Please apply, forward to suitable candidates, and/or repost; many thanks! Deadline February 24, 2025. See www.ulm-lab.ch for more information.

submitted 67 days ago • 0 comments

Inspired by recent discoveries on ubiquitin-mediated condensates under physiological and stress conditions, we wrote this review on the intersection of protein quality control, phase separation, and function! #PQC #UPS #autophagy #ubiquitin #condensates

submitted 83 days ago • 0 comments

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

submitted 70 days ago • 1 comment

Beautiful work from the Torii lab showing a toggle switch mechanism for the ERECTA receptor #proteostasis

submitted 66 days ago • 1 comment

Our latest @pnas.org! Preventing inappropriate signals pre- and post-ligand perception by a toggle switch mechanism of the plant receptor kinase ERECTA. Its unique C-terminal alpha-helix domain inhibits the receptor active state. Congrats, all!🌱🥰 www.pnas.org/doi/epub/10....

submitted 68 days ago • 2 comments

TSL alumni & friends at Gordon Conference Plant Proteolytic Pathways, Tuscany, Italy 🇮🇹 Standing (l to r): Steven Spoel, Tolga Bozkurt, Marco Trujillo, Suayib Ustun, Enoch Lok Him Yuen Sitting: Yasin Dagdas, Ari Sadanandom, Saskia Hogenhout, Sophien Kamoun

submitted 67 days ago • 0 comments

Shedding light on plant proteolysis: genetically encoded fluorescent sensors as tools for profiling protease activities. www.biorxiv.org/content/10.1...

submitted 67 days ago • 0 comments

This is not proteolysis, it’s autophagy! #PacMan

submitted 67 days ago • 1 comment