walterwchen.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

submitted 20 hours ago • 1 comment

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...

submitted 1 day ago • 0 comments

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social! www.cell.com/current-biol...

submitted 6 days ago • 0 comments

Another great day for #relentlessdiscovery & #CancerResearch: 🟠 Sam McBrayer, Ph.D., received $1.19M to study developmental origins of IDH-mutant glioma in adolescents 🟠 Michalis Agathocleous, Ph.D., received $900K to study role of glutathione in leukemia development from CPRIT 🧪 shorturl.at/pgKmG

submitted 5 days ago • 0 comments

🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics 🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social

submitted 7 days ago • 3 comments

1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer This long-term commitment allowed us to connect tumor metabolic features to patient outcomes We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC

submitted 7 days ago • 4 comments

Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶

submitted 8 days ago • 0 comments

What an honor to be included in this lineup! Looking forward to speaking at the International Webinars on Cell and Tissue Engineering this spring. Thanks to João Mano for the invitation!

submitted 8 days ago • 0 comments

Incredibly proud of @larawahlster.bsky.social from our group, who received the 2025 @[email protected] Pediatric Cancer Research Fellowship!!! Congratulations, Lara!!! www.damonrunyon.org/news/entries...

submitted 12 days ago • 1 comment

excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!

submitted 14 days ago • 2 comments

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

I'm co-organizing a Cell Symposia on Metabolites in Organellar Communication with @robzonculab.bsky.social, Kivanc Birsoy, and Allyson Evans (@cp-cellmetabolism.bsky.social). It will be in Sitges May 11-13. Submit an abstract by Feb 14. Hope to see you in Spain! cell-symposia.com/metabolites-...

submitted 12 days ago • 0 comments

Tremendous honor to receive this award from @socpedresearch.bsky.social ! The past recipient list is truly amazing with many of my mentors and role models.

submitted 13 days ago • 3 comments

Tremendous effort and great native organellar interactome resource from Miguel and co in @harperlabhms.bsky.social : a crosslinking-MS, co-fractionation, and alphaFold interactome on isolated EEA1+ endosomes (+discovery/validation!) | www.biorxiv.org/content/10.1...

submitted 13 days ago • 0 comments

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

submitted 15 days ago • 1165 comments

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

submitted 16 days ago • 86 comments

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6 www.science.org/doi/10.1126/...

submitted 18 days ago • 9 comments

Excited to share our new study on translocation RCC (tRCC) in collaboration with @liron1bar-peled.bsky.social. We reveal how the TFE3 fusion drives a key oxidative phosphorylation (OXPHOS) metabolic program in this rare kidney cancer. trebuchet.public.springernature.app/get_content/... 1/

submitted 19 days ago • 2 comments

Congrats, Gerta! Sandwiched between two spectacular scientists, @seanjmorrison.bsky.social & @rjdlab.bsky.social. This photo shows the possibilites with #CRIcollaboration and #relentlessdiscovery. 🧪 Onward! 2025 TAMEST Mary Beth Maddox Award. #TAMEST2025 Read more 👉 cri.utsw.edu/hoxhaj-named...

submitted 19 days ago • 0 comments

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC: www.cell.com/cell/fulltex...

submitted 20 days ago • 4 comments

🧪Thrilled to share the latest research from the lab of my awesome @umasschan.bsky.social colleague Jessica Spinelli (who isn't on here yet) and collaborators: www.cell.com/cell/fulltex...

submitted 21 days ago • 3 comments

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria

submitted 31 days ago • 19 comments

Deeply honored to receive the Presidential Early Career Award for Scientists & Engineers (PECASE) from the White House - 7 years after becoming a U.S. citizen! Grateful for the family, friends, teachers, mentors, & students who have supported my journey 🙏🏽 www.whitehouse.gov/ostp/news-up...

submitted 41 days ago • 15 comments

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

submitted 42 days ago • 7 comments

⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development! keysym.us/KSMetabDev25 The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!

submitted 50 days ago • 0 comments

One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...

submitted 48 days ago • 0 comments

Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease. So proud of our lab & their cell biology adventures! #onward_science

submitted 49 days ago • 4 comments

The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!

submitted 52 days ago • 0 comments

New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social rdcu.be/d5ptF

submitted 53 days ago • 1 comment

Very impressive application of the organellar tag immunopurification techniques for studying organellar biology. Congrats to all the authors! www.cell.com/cell/fulltex...

submitted 55 days ago • 0 comments

Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...

submitted 56 days ago • 6 comments

Helpful infographic from the NCI on the new K32 mechanism

submitted 57 days ago • 0 comments

Congrats Hank!! 🎉🥳

submitted 59 days ago • 1 comment

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ

submitted 61 days ago • 0 comments

Happy holidays from RJDLab, whose fantastic and creative members surprised the PI with this series of photos spelling out our full name. -RJD

submitted 63 days ago • 1 comment

www.statnews.com/2024/11/27/p...

submitted 64 days ago • 0 comments

Any lab would be so lucky to get someone like @dwendscheck.bsky.social as a postdoc! Having worked with him on a complex research project, I can confidently say that he is an excellent scientist and person!

submitted 65 days ago • 1 comment

Congratulations to the amazing Gerta Hoxhaj! #TAMEST. -RJD cri.utsw.edu/hoxhaj-named...

submitted 69 days ago • 0 comments

Christmas came early with a copy of the new textbook on cancer metabolism from #NoTwitterNav, @labvousden.bsky.social, @rjdlab.bsky.social 🥳 Happy to contribute a section on MITO-IP and other rapid organellar immunopurification techniques for studying organellar metabolism!

submitted 68 days ago • 1 comment

Still at ASCB tomorrow? Excited about the endoplasmic reticulum in neurons and other cell types? Join us in the Endoplasmic Reticulum Structure and Function Across Different Cell Types subgroup Dec 18th at 9:00am in Room 28C.

submitted 69 days ago • 0 comments

Had a wonderful time at #CellBio2024 catching up with old friends and making new ones! Thanks @nieminm.bsky.social @labfriedman.bsky.social for the opportunity to speak and organizing an excellent session on organelles!

submitted 70 days ago • 2 comments