A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6 www.science.org/doi/10.1126/... - ThreadSky

soleimanpourlab.bsky.social • 18 days ago

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6
https://www.science.org/doi/10.1126/science.adf2034

Comments

elias-adriaenssens.bsky.social•17 days ago

This sounds super interesting! Congratulations, can’t wait to read it!

soleimanpourlab.bsky.social•17 days ago

Thank you much! We really appreciate it!!!

soleimanpourlab.bsky.social•18 days ago

We found that interrupting distinct mitochondrial quality control pathways in several metabolic tissues (pancreatic beta cells, liver, brown fat) led to a common program in both mouse and man to elicit cellular immaturity, rather than death, and induce metabolic dysfunction. 2/6

soleimanpourlab.bsky.social•18 days ago

We could not have finished this story without these two amazing first authors, Emily Walker and Gemma Pearson, who gave everything to get this paper to the finish line. I am so lucky to work with the most amazing people who are way smarter than me! 3/6

soleimanpourlab.bsky.social•18 days ago

I also have to thank everyone in my lab and our wonderful collaborators, who all pulled together to see this through. 4/6

soleimanpourlab.bsky.social•18 days ago

This was a true testament to the power of wonderful science, brilliant colleagues, and teamwork after >10 years of work, 27 figures, 218 panels of data, and 2.5 years of peer review. Also deepest gratitude to the amazing editor and reviewers who helped make our work stronger! 5/6

soleimanpourlab.bsky.social•18 days ago

A thank you for generous support from the NIDDK,
@breakthrought1dhq.bsky.social, the VA, the ADA, as well as organ donors and their families. And a special thank you to our families and friends who supported all of us to see this through! We can never thank you enough! 6/6