wyd20.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

It’s #WorldImmunizationWeek Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute. A reminder of what is #HumanlyPossible. Science saves lives. #VaccinesWork bit.ly/wiw2025

submitted 1 day ago • 12 comments

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

submitted 15 days ago • 3 comments

Interesting!

submitted 22 days ago • 0 comments

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

submitted 60 days ago • 13 comments

What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?

submitted 73 days ago • 0 comments

Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design

submitted 73 days ago • 0 comments

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

submitted 75 days ago • 3 comments

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

submitted 75 days ago • 50 comments

No idea how the academic world would cope without pubmed

submitted 85 days ago • 0 comments

Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS) media.springernature.com/full/springe...

submitted 93 days ago • 0 comments

Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence evidence.nejm.org/doi/full/10....

submitted 106 days ago • 1 comment

This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1. #H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it. www.nejm.org/doi/full/10....

submitted 114 days ago • 8 comments

Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease #nephsky #medsky #pedsky

submitted 117 days ago • 0 comments

😱 Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔

submitted 125 days ago • 0 comments

#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating

submitted 129 days ago • 4 comments

A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social

submitted 136 days ago • 0 comments

Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".

submitted 137 days ago • 0 comments

Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍 In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/ #KidneyCareUK #CKD #CKDSupport #Dialysis

submitted 146 days ago • 0 comments

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

submitted 150 days ago • 35 comments

1/9 🤔 Why doesn't an elevated BUN lead to extreme thirst? If increased serum osmolarity compels us to seek water, uremia should be a significant driver of this craving. And yet, it isn't. Let's examine why.

submitted 148 days ago • 6 comments

❤️Great visual abstract of the original ISKDC study for NS from 50 years ago! high dose steroids magically melts away childhood NS but can we do better? In an ideal world: ✔️equally efficacious induction therapy ✔️minimal side effects ✔️cost effective-equal access in LMICs where NS incidence higher

submitted 148 days ago • 0 comments

😱 although hopefully a risk factor only in select age groups.

submitted 150 days ago • 0 comments

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d6: you guessed it - postrenal AKI

submitted 159 days ago • 1 comment

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d5: intrarenal AKI

submitted 160 days ago • 1 comment

Loving these kidney cartoons 🥰

submitted 152 days ago • 0 comments

theipna.org/ipna-2024-pr... Please support the phenomenal @RukshanaShroff who is running as President Elect for @IPNA_PedNeph - the future of paeds neph would be in safe hands if successful.

submitted 155 days ago • 0 comments

Looks like a great resource, will be directing vaccine hesitant parents to this, as often tricky to cover this in any great detail in a paediatric nephrology clinic.

submitted 153 days ago • 0 comments

& Paediatrics starter pack here

submitted 157 days ago • 0 comments

Starter pack specific for #PedNeph professionals. Hard to keep to with everyone joining so please let me know if you want to be added or see anyone missing! go.bsky.app/DEJdD5

submitted 165 days ago • 3 comments

Bristol Royal Hospital for Children Journal Club today: NefIgArd (Lancet 2023). Really promising data showing oral targeted-release Budesonide for 9 months results in significant eGFR difference (5.05ml/min/m2, p<0.0001) and reduction in proteinuria at 2 years when compared against placebo. 1/

submitted 157 days ago • 1 comment