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zaminiqbal.bsky.social
Professor of Algorithmic and Microbial Genomics at the University of Bath (UK). Pangenomes, drug resistance (esp TB), data structures for DNA search, plasmid evolution, global microbial surveillance. Open Data, reproducibility
519 posts 5,501 followers 4,254 following
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globally, there are ~3500 described mosquito species in the Culicidae family and many of these are important vectors of disease but only a small percentage have genomic resources. we are launching a pilot project to generate high quality reference genomes for 100 important mosquito species [1/3]

Btw this is an actual movie, shot with a Canon DSLR in a photo studio incubator, of fluorescence-expressing plasmids competing and segregating inside cells

What can I do that’s cheap, not affected by the rain/weather for 20 kids for a 10th bday party? Southeast London.

"ROCKET.. refines [Alphafold2] predictions using cryo-EM, cryo-ET, and X-ray crystallography data... this approach captures biologically important structural variation that AlphaFold2 does not... ROCKET automates difficult modeling tasks, such as flips of functional loops and domain rearrangements"

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

This is AMAZING work

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

🚨 #PhD opportunity! 🚨 Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬 Details here: www.strath.ac.uk/studywithus/...

Does anyone here have experience with MCMCglmm? I'm using a multivariate model to estimate correlations behaviors variables, and I find that the strength of the correlations are impacted by scaling the data (which doesn't make sense to my little lmer brain). I want to know why! #BlueSci #Stats ‪

With @CostaT_Lab, we challenged AI co-scientist to generate scientific hypotheses. It correctly predicted how cf-PICIs spread between bacterial species, matching our unpublished, experimentally confirmed mechanism! 🤯 @imperialcollegeldn.bsky.social www.biorxiv.org/content/10.1...

ok, this I did not expect!

AI is poised to accelerate understanding in infectious diseases, but its value needs to be demonstrated through close collaboration between research, industry, society, and policy. Paper free to read: rdcu.be/eaxEw Summary here: www.ox.ac.uk/news/2025-02...

A rebuttal of the paper that looked at historical samples and found evidence of natural selection due to the Black Death at immune loci. Multiple lines of evidence, incl that observed freq changes were an artefact. By Alison Barton, @mathiesoniain.bsky.social et al www.nature.com/articles/s41...

New guidelines recommend shorter treatment for both drug-susceptible and #AMR #tuberculosis, significantly reducing treatment duration for most patients. These regimens aim to improve adherence, reduce side effects, and lessen the burden on healthcare systems. #TB www.atsjournals.org/doi/full/10....

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

New preprint, in these chaotic times: www.biorxiv.org/content/10.1... in which we use digital droplet PCR to detect scarce & tiny tapeworms in zooplankton samples from lakes (their 1st host)

Doing the unthinkable: The deep cuts to the #CDC's workforce today are expected to decimate the Epidemic Intelligence Service, a program that has trained public health rapid responders for decades. Envy of the world. Poof! www.statnews.com/2025/02/14/t...

Latest blogpost on Musk/Royal Society debacle: deevybee.blogspot.com/2025/02/seve... I look at the reasons that have been given for inaction, and find them wanting. @royalsociety.org

𝗣𝗿𝗼𝘃𝗼𝗰𝗮𝘁𝗶𝘃𝗲: 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗳𝘂𝗲𝗹𝘀 𝗔𝗠𝗥 Staphylococcus aureus evolves antibiotic resistance rapidly in diabetic mice, as hyperglycemia aids the expansion and takeover of resistant mutants VISA strains have a large fitness defect in control mice but not in diabetic mice ➡️ www.science.org/doi/10.1126/...

This is amazing. Via @nytimes.com

New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social! How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair! Read more 👉 https://doi.org/10.1101/2025.02.10 Follow along for key insights! 🧵

Writing this with a heavy heart: the refugee citizenship ban is the single most unconscionable policy Labour has proposed since it entered power. It’s the moment that I felt my support for this administration begin to crumble inews.co.uk/opinion/colu...

Better performance bounds on search in an open addressing hash table, O(log(n)^2) (I would put !!! But it might be misinterpreted) Paper arxiv.org/abs/2501.02305 Write up www.quantamagazine.org/undergraduat...

This is batshit mad.Things that spread between bacteria by hijacking phage tails "These subcellular entities then interact with phage tails from various species, forming chimeric particles that inject DNA into different bacterial species depending on the tail present" www.biorxiv.org/content/10.1...

“This is bad, full stop. It creates a class of person who are forever excluded from civic life no matter how long they live here. It’s also a clear breach of the refugee convention.” Damn straigt, @colinyeo.bsky.social www.theguardian.com/politics/202...

Huge analysis out as a preprint today! For every 9 years an animal spends in the wildlife trade, it shares an additional pathogen with humans. Clear long-term impacts based on 40 years of global trade data 🧪😷 biorxiv.org/content/earl...

A thread on my latest paper, Adenovirus-Specific T Cells in Adults Are Frequent, Cross-Reactive to Common Childhood Adenovirus Infections and Boosted by Adenovirus-Vectored Vaccines onlinelibrary.wiley.com/doi/full/10.... #ImmunoSky #Virology @geneticscam.bsky.social

The beautiful pink forced rhubarb is around now, and while I do love to make a crumble with it, it’s also at the centre of this special cake, a wonderful way of celebrating the sherbetty stalks. That’s to say, #RecipeOfTheDay is my Toasted Marshmallow and Rhubarb Cake www.nigella.com/recipes/toas...

Watercolor skies

An important study showing that prolonged exposure to higher temperatures makes #Aedes albopictus more tolerant of #viral infection - with important implications for vector-borne diseases in a warming world. #symbiosky #evovir @uoe-eid.bsky.social

Did you know that a famous math reference – most physicists have owned a copy at some point – is the result of a New Deal project to employ scientists and mathematicians? Thread incoming.