I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful... - ThreadSky

roisinmcmanus.bsky.social • 134 days ago

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
https://www.cell.com/immunity/fulltext/S1074-7613(25)00032-9

Comments

grampafan.bsky.social•134 days ago

Keep up the good work.

aosasmita.bsky.social•134 days ago

Massive congrats on the fascinating work!! 🎉

murphyroyallab.org•134 days ago

Really nice paper Róisín, congrats!
Will I see you at EuroGlia this summer?

roisinmcmanus.bsky.social•132 days ago

Oh I’m not going this year 🙈 have another appointment. Hope we can catch up soon!

hubbubhullabaloo.bsky.social•134 days ago

I’m going to ask AI to dumb this down for me. 😂

roisinmcmanus.bsky.social•134 days ago

It was a long journey, where I led this study through 2 postdocs & did some revisions in my new lab @dzne.science. Thanks to @Michael Heneka & @Eicke Latz, & all our collaborators across Germany, Luxembourg, Northern Ireland, Spain, Sweden, Switzerland and USA (2)

roisinmcmanus.bsky.social•134 days ago

Thanks to the reviewers and editors @cellpress.bsky.social for their insightful comments and helpful suggestions (3)

roisinmcmanus.bsky.social•134 days ago

From my side this work would not have been possible without generous support from @afi-ev.bsky.social, @immunosens.bsky.social , @sfb1454.bsky.social @dfg.de and the @alzassociation.bsky.social (4)

roisinmcmanus.bsky.social•134 days ago

If you’re curious whether this mechanism is relevant for other pathways or cell function, stay tuned for our next story from the McManus lab that we will be submitting soon! (5)

roisinmcmanus.bsky.social•134 days ago

A thread on our main findings:
During my postdoc I noticed something surprising, where NLRP3-/- microglia were much better at #phagocytosis than wild-type cells even under basal (unstimulated) conditions (6)

roisinmcmanus.bsky.social•134 days ago

To uncover what was driving this, we did single cell RNAseq. This unveiled a population of NLRP3-/- microglia with a strong metabolic and phagocytic signature, and the most significantly changed gene was the glutamate transporter Slc1a3 (7)

neuroscientistt.bsky.social•134 days ago

Congrats Róisín 👏🏼

ruizdealmodovar.bsky.social•134 days ago

Congrats!

barryboland.bsky.social•131 days ago

Well done!

Comments

Posting Rules

Reply