Very happy that this story is now published in @plosbiology.org. It includes lots of additional data, (creation of the G215S mutant) & demonstrates the increased growth/ oligomerization of N is specific to the cysteine at 215. Thanks to the coauthors, reviewers and editors who helped improve it!
Reposted from
Emily Bruce
1/n Very excited to share my lab's latest manuscript, 3 years after I started my independent group! This was a fantastic collaboration with Bryan Johnson and @themenacherylab.bsky.social , led by joint 1st authors Hannah Kubinski and Hannah Despres in my lab www.biorxiv.org/content/10.1...
Comments
We observed some 214C lineages under omicron without much success.
I was thinking of this paper just a few days ago as I read a study about a model of the replication-transcription complex proposing that dimerized N loads the TRS-L & holds it just above exiting RNA.