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drchrispook.bsky.social
Biochemistry, mass spectrometry, metabolomics, chromatography, metabolism, health, nutrition, physiology, chemoinformatics, computational mass spec, Python. Personal account. #SexMatters #SexNotGender https://projectnettie.wordpress.com/
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Really looking forward to my lecture on LC and mass spec today. Actually struggling to keep the enthusiasm in check. #LCMS 🀩

archive.is/eUZ3c

Today's XKCD comic receives douze points from the mass spec jury (and popular vote, I am sure):

"Targeted" metabolomics. πŸ™„

Wow, look at this: the carbon intensity of UK electricity is currently only 32g/kWh and 86.5% of our electricity right now is coming from renewables. Come on world, this IS possible! And it will only get better (meaning: cleaner, healthier, less intrusive) πŸŽ‰ (graphic from grid.iamkate.com )

Wow! Mitochondria can actually be transferred to other cells if needed through nanotubes, in extracellular bubble-shaped vesicles, or by free floating through the blood. buff.ly/33kcDdS Donating mitochondria to another cell may help to repair damaged cells or support immune function. #medsky πŸ§ͺ

Following the Supreme Court judgment on the meaning of "sex" in the 2010 Equality Act, we have published an addendum to our report on data and statistics on sex and gender. This explains how the judgment dovetails with the recommendations of the review. www.sullivanreview.uk/addendum.php

This paper represents a great effort by @roman-bushuiev.bsky.social and his brother @anton-bushuiev.bsky.social. The DreaMS foundation model for mass spectra of small molecules now opens lots of avenues for possible downstream applications. It might be a game changer for computational metabolomics.

OpenAI just updated ChatGPT to be able to use RDKit, a cheminformatics Python package. OpenAI's president says this makes ChatGPT "useful for scientific work across health, biology, and chemistry," but it is hilariously still not good at chemistry (🧡) #chemsky #AI βš—οΈπŸ§ͺπŸ–₯️

Metabolomic biomarkers in vitreous humor: unveiling the molecular landscape of diabetic retinopathy progression #IJRV journalretinavitreous.biomedcentral.com/articles/10....

This is "Staniland's Razor". Kudos and respect to @helenstaniland.bsky.social

New preprint! 🚨 Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies doi.org/10.1101/2025...

A massive failing in our time is political and cultural incuriosity. If you treat disagreement as a problem rather than an opportunity to gather more information and weigh your own views, then you stagnate

I am registered for #Metabolomics2025. Looking forward to meeting some of the #metabolomics legends I interact with here in person.

Science! Γ‡a marche!

Good morning, bleeps. 🌺

One is blessed with rather exceptional sunsets here in Samoa.

New release of my "Hands-on Introduction to Data Science with Python" textbook! Contains many text edits and figure updates. For instance, in the sections on Clustering and Machine Learning. All fully #opensource and #openaccess. Figures are #CCBY. --> florian-huber.github.io/data_science...

Good morning, Auckland. 🌺🌺

Our latest manuscript describes an #LCMS platform profiling Phase II metabolites. We annotated 424 mercapturates, glucuronides, sulfates linked to over 200 environmental chemicals. This demonstrates ILGA's value for advancing #Exposomics Link doi.org/10.1016/j.en... #MassSpectrometry #Metabolomics

Very cool study from @nadlerlab.bsky.social and @pavelbarahtjan.bsky.social β€” why do cells have asymmetric membranes? Among other reasons, it is a way to store potential energy. Fascinating! #lipidtime

Morning mental health break. 🌺🌺🌺🌺

This is a very complex and expensive way to show that nurses eat more chocolate than office workers. #theophylline LOL, just kidding! 😁 It's a really neat application of #untargetedMS.

GPT-like models trained with bio data (mostly RNA) are likely to learn correlation patterns and make useful interpolations (predictions). Since their correlative patterns reflect indirect correlations, extrapolations should be interpreted with caution.

🎀 Pitch Perfect: EMCR Presentation Practice 🎀 Got a talk at #AUSoMicS? Or just want to polish your pitch? Join this session to practise, get expert feedback & boost your confidence! πŸ—“οΈ Re-scheduled: 7 May 🎟️ Limited spots tinyurl.com/8u8aue25 #Metabolomics #ANZMetSoc #Student #ECR #Presentation

What is the most compelling vision you have seen on how AI can contribute to biomedical research ? I am particularity interested in specific, tangible proposals that go beyond obvious applications to supervised learning. Supervised learning models ... 1/2