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drchristhorpe.bsky.social
Immunology/bioinformatics. Working towards higher fidelity models of MHC:peptide complexes/tools for immunologists/equity in data EMBL / Marie Skłodowska-Curie Actions ARISE fellow. https://orcid.org/0000-0002-4341-0320 https://www.histo.fyi/
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Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells @natcomms.nature.com @drakesmith-lab.bsky.social www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

🧪 We're beta testing - and we want your thoughts! Try the redesigned PDBe entry pages & let us know: 🔸 What’s working? 🔸 What’s confusing? 🔸 What features do you miss? 💬 Feedback form: tinyurl.com/pdbe-beta-form #PDBeBeta #Bioinformatics #Biochemistry #Science #UserVoice

submitted 4 days ago • 0 comments

www.theguardian.com/society/2025... Ondine did such a huge job to get recognition for all with Long Covid👇

submitted 4 days ago • 2 comments

We're recruiting three roles at @sangerinstitute.bsky.social! ➡️ Principal/senior data scientist and a (senior) postdoctoral fellow in the Lotfollahi group. Closes 6/8 July ➡️ Advanced Research Assistant to join Open-IBD with @carlanderson.bsky.social. Closes 25 June www.opentargets.org/jobs

submitted 4 days ago • 0 comments

Here's an interesting finding about antibody-antigen binding data: the most common antigen-binding AA in antibodies is tyrosine, but the most common AA in antibody mutagenesis datasets is alanine; as a result, most ML methods suck at generalizing antigen binding to non-alanine mutants

submitted 8 days ago • 2 comments

Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.

submitted 5 days ago • 1 comment

Very interesting preprint from @opig.stats.ox.ac.uk arxiv.org/abs/2505.077... From a quick play with Claude Sonnet yesterday, it seems to understand quite a lot about SMILEs representations.

submitted 18 days ago • 0 comments

Can we get to 40K by midnight? Yes, if we try - please sign or ask a friend to sign

submitted 19 days ago • 10 comments

The EMBL #ARISE2 Fellowship Programme, funded by MSCA, will open for applications on 30 June. This unique opportunity trains researchers to lead #ResearchInfrastructures & innovate in the #LifeSciences. 🧪 🗓️ Join our webinar on 17 June at 15:00 CET: embl-org.zoom.us/meeting/regi... #careers

submitted 21 days ago • 0 comments

Another fascinating group of T-cells with exceptionally interesting functions/locations. www.nature.com/articles/s41...

submitted 24 days ago • 0 comments

A reminder that South African researchers gave the world crucial early insights into the Beta, Omicron BA.1 and BA.4/5 variants, as well as valuable ongoing work into many other pathogens/outbreaks…

submitted 31 days ago • 2 comments

Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto www.science.org/doi/10.1126/...

submitted 32 days ago • 2 comments

🌈 Let's celebrate diversity in immunology across immune responses, research & researchers! Join us in London on 11 July for #LIG2025 - abstracts are due 1 June, early bird tickets until 25 June. Submit your abstract, register & join the conversation 👉 https://bit.ly/3CLQTj7

submitted 32 days ago • 0 comments

Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans: Cell Reports Medicine www.cell.com/cell-reports...

submitted 33 days ago • 1 comment

Michael Rosen on the 'island of strangers'. www.youtube.com/watch?v=ih0W...

submitted 34 days ago • 0 comments

Very happy for Palace and their fans. Thinking @benansell.bsky.social will be very happy right now.

submitted 36 days ago • 0 comments

Anyone who has benefitted from the outstanding NHS knows that we live on a rich, multicultural society wth the very best of people; these are not strangers they're heroes.

submitted 36 days ago • 0 comments

Absolutely wonderful words from Michael Rosen responding to Starmer’s “Island of Strangers” with the caring vital role people of all nations are cornerstones of our health care

submitted 37 days ago • 1 comment

I've been working on this for a while... llm --functions ' def multiply(x: int, y: int) -> int: """Multiply two numbers.""" return x * y ' 'what is 34234 * 213345' -m o4-mini https://simonwillison.net/2025/May/14/llm-adds-support-for-tools/

submitted 40 days ago • 1 comment

Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur www.nature.com/articles/s41...

submitted 40 days ago • 3 comments

New ways/data to dial the immune system up or down —Probiotics to increase Treg cells, potential adjunct for multiple sclerosis and autoimmune diseases www.thelancet.com/journals/ebi... —NK cells for cancer www.nature.com/articles/s41...

submitted 41 days ago • 3 comments

We shipped multi-agents today! Our chemistry design agent can now call Crow, our scholarly research agents, to bring in data from literature/clinical trials/open targets while designing molecules. platform.futurehouse.org

submitted 41 days ago • 0 comments

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis: Immunity www.cell.com/immunity/ful...

submitted 41 days ago • 0 comments

"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."

submitted 42 days ago • 2 comments

2050: All video call services are now heavily AI moderated. Due to poor choice in training data you must now wear a fake beak in order to join a call. Push to squawk.

submitted 42 days ago • 0 comments

The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution Thanks for coming to my TED talk

submitted 142 days ago • 5 comments

www.nature.com/articles/s41...

submitted 43 days ago • 0 comments

Just appalling. Destroying the air quality of a local Black community, with raised hospital admissions for asthma. www.politico.com/news/2025/05...

submitted 43 days ago • 0 comments

On the Covid SARS-CoV-2 variant front, new CDC update today —LP.8.1 furthers its dominance —No new emerging one of concern (some increase in XFC noted and will keep an eye on that) —good, important for these reports to continue

submitted 45 days ago • 9 comments

Really fascinating looking fellowship with the Ghafari group in Oxford, including analysis of structural predictions through a pathogen evolution lens. my.corehr.com/pls/uoxrecru...

submitted 45 days ago • 0 comments

An atlas predicting protein interactions in 11 human tissues created by @pedrobeltrao.bsky.social's team at @imsb-eth.bsky.social will help uncover cell-type specific functions, elucidate disease mechanisms, and choose safer targets for drug discovery 🧬🖥️ blog.opentargets.org/an-atlas-of-...

submitted 48 days ago • 0 comments

Very important work! We've been waiting for someone to do this. It has been clear for some time that a proportion of aggregated TCR-pMHC data might not be reliable. It will be interesting to reassess performance in light of this more robustly validated data.

submitted 52 days ago • 0 comments

One in six people live in Sub-Saharan Africa, but it accounts for two-thirds of global extreme poverty

submitted 54 days ago • 2 comments

That point in writing a document where only the wonderful music from the Opening Ceremony of the London 2012 Olympics and a Calippo as a treat will do.

submitted 56 days ago • 0 comments

Blog—Unlocking innovation & the critical shortage of lab technicians @athenedonald.bsky.social explores how local investment in growth requires a skilled workforce, which must include technicians to support innovation in life sciences & digital sectors. www.bennettinstitute.cam.ac.uk/blog/unlocki...

submitted 56 days ago • 1 comment

petition.parliament.uk/petitions/71... What do you mean, you haven't signed the Parky Charter petition calling for better Parkinson's care?? We Parkies have an excuse - one of the symptoms of PD is apathy. But as for the rest of you, jump to it! (pretty please..)

submitted 64 days ago • 21 comments

Super excited to be presenting Dyna-1 next week with @hkws.bsky.social !!

submitted 61 days ago • 2 comments