eugenevalkov.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

submitted 1 day ago • 8 comments

I guess it depends on which humans he’s referring to

submitted 3 days ago • 0 comments

Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores). Spirit: chembio-shop.fourthwall.com/products/grc... World Tour: chembio-shop.fourthwall.com/products/spi...

submitted 4 days ago • 6 comments

Please check out our new approach to modeling somatic mutation signatures. DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪 www.biorxiv.org/content/10.1...

submitted 4 days ago • 0 comments

Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators. www.science.org/doi/10.1126/...

submitted 6 days ago • 0 comments

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath Was just told they're looking for a structural biologist using cryoEM (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

submitted 7 days ago • 1 comment

😬

submitted 10 days ago • 0 comments

#RNAsky #RNAbiology

submitted 11 days ago • 0 comments

LocScale-SURFER is now also available for quick install via the ChimeraX toolshed: cxtoolshed.rbvi.ucsf.edu

submitted 12 days ago • 0 comments

#RNAsky #RNAbiology

submitted 12 days ago • 0 comments

This is cool! The Every Kid Outdoors pass allows fourth graders and their families to receive free entrance to Federal public lands and waters during their fourth-grade school year (September-August). 1/n everykidoutdoors.gov/index.htm

submitted 13 days ago • 6 comments

#RNAsky #RNAbiology

submitted 17 days ago • 0 comments

Our trainees invited @nickingolia.bsky.social as speaker in the RNA Biology seminar series. Cool insights into roles of protein disordered regions in mRNA decay regulation!

submitted 18 days ago • 0 comments

And this is the presumed prey- Eastern Chipmunk (Tamias striatus)

submitted 19 days ago • 0 comments

Northern Black Racer (Coluber constrictor constrictor) in our garden

submitted 19 days ago • 1 comment

Show us your writing process in a gif

submitted 20 days ago • 0 comments

Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates. Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪

submitted 22 days ago • 4 comments

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

submitted 23 days ago • 3 comments

As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...

submitted 24 days ago • 0 comments

Australian Gruffalo

submitted 29 days ago • 0 comments

A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography journals.iucr.org/a/issues/202...

submitted 32 days ago • 1 comment

More funding is always good, but frankly not much “top global talent” will be attracted by €500M

submitted 32 days ago • 1 comment

This funding will be competed for and divided among already well funded European labs.

submitted 32 days ago • 0 comments

The perfect end to the weekend

submitted 33 days ago • 0 comments

How does yeast count to 60? #RNAsky #RNAbiology

submitted 35 days ago • 0 comments

Nothing like a good-looking Nanopore run!

submitted 35 days ago • 1 comment

And how was your day, Ivy?

submitted 36 days ago • 0 comments

Woah- going to try this out!

submitted 37 days ago • 0 comments

A collection of horrors👇🏻

submitted 37 days ago • 0 comments

My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681

submitted 37 days ago • 0 comments

One person’s junk is another’s treasure. Pulled this out of our surplus equipment store - and it works! $1000s saved

submitted 37 days ago • 1 comment

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵 🌐 afesm.foldseek.com 📄 www.biorxiv.org/content/10.1...

submitted 41 days ago • 4 comments

#RNAsky #RNAbiology

submitted 39 days ago • 0 comments

Scientists from the IIMCB described a new mechanism that improves the efficiency of mRNA-based therapies. The research findings will facilitate the development of novel therapeutics against cancers and infectious diseases. #NaturePublication #mRNA #RNAResearch #IIMCB #FunduszeUE

submitted 39 days ago • 0 comments

show me a picture on your phone that has your energy that isn’t a selfie

submitted 39 days ago • 0 comments

In December I accepted a position as a senior investigator at the NIH in the National Human Genome Research Institute & Center for Genomics and Data Science Research. Bringing the party in the desert to Maryland. We are hiring postdocs & postbacs! Please reach out :)

submitted 40 days ago • 13 comments

A Salt & Battery calamari & chips at St Lucia, Brisbane, Australia

submitted 42 days ago • 1 comment

I watched this movie as a kid maybe 30 times?

submitted 42 days ago • 1 comment

Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism Peter Andersen @germline.bsky.social and collaborators www.embopress.org/doi/full/10....

submitted 43 days ago • 1 comment

#RNAsky #RNAbiology

submitted 43 days ago • 0 comments

💡Protein lovers - a brand NEW video exploring AlphaFold's pLDDT score in Jalview is out! Find out how you can select, hide and colour your alignments using this 3D structure prediction confidence metric. ▶️ Watch the full video here: www.youtube.com/watch?v=WVCM...

submitted 45 days ago • 1 comment

#RNAsky #RNAbiology

submitted 44 days ago • 0 comments

Will be taking a deep dive into this today. Congrats to Joe Lobel and Nick Ingolia! #RNAsky #RNAbiology www.nature.com/articles/s41...

submitted 44 days ago • 0 comments