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hamishs.bsky.social
Analyzer evangelist and mass spectrometry enjoyer. Read about the Astral analyzer: https://pubs.acs.org/doi/10.1021/acs.analchem.3c02856
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Posts 12 Comments 38

A new dimension for multiplexing mass spec analysis -- time -- is enabling scaling up throughput at new levels. We demonstrate 27-plex DIA enabling over 500 samples / day. We project that timePlex will enable throughputs exceeding 1,000 samples / day. www.biorxiv.org/content/10.1...

submitted 1 day ago • 2 comments

News in Proteomics Research blog post | MAP-MS! Get more Orbitrap dynamic range for free! proteomicsnews.blogs... --- #proteomics #prot-other

submitted 9 days ago • 0 comments

Neil Kelleher: The Human Proteoform Project Could Transform Medicine theanalyticalscienti... --- #proteomics #prot-article

submitted 25 days ago • 1 comment

Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: www.hecklab.com/advanced-pro...

submitted 30 days ago • 1 comment

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm that deconvolves any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying analysis of bottom-up proteomics data. @msaid-de.bsky.social @kusterlab.bsky.social www.nature.com/articles/s41...

submitted 36 days ago • 0 comments

Nice reassuring thread on Astral uptime. Trends away from large injections and towards wider adoption of FAIMS are a boon.

submitted 49 days ago • 0 comments

Mass spectrometers appearing in the news, in this case the work of the Murdoch Children's Research Institute. www.foxnews.com/health/inter...

submitted 73 days ago • 0 comments

We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work

submitted 83 days ago • 0 comments

Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates. They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice. www.biorxiv.org/content/10.1...

submitted 92 days ago • 3 comments

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

submitted 132 days ago • 2 comments

Enlightening and accessible work from Josh Coon's group. It's good to see comparisons coming up. Wonder how many more Olink proteins would be shared with the deeper multi-fraction Seer/Astral analysis with 6k IDs.

submitted 133 days ago • 1 comment

New publication by Serrano et al. describes deep analysis of the human proteome in less than 1 hour! This paper describes the process and how it takes advantage of the new Orbitrap Astral mass spec high acquisition speeds. www.mcponline.org/article/S153...

submitted 142 days ago • 0 comments