Results 10 yrs metagenomic sequencing for CNS infections https://www.nature.com/articles/s41591-024-03275-1
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
Impressive.
Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.
1 / 2
Comments
1,053 UCSF patients > 220 infectious diagnoses > 48 by mngs alone. So 21.8% or 4.5% depending on denominator.
Clearly a good test in people who have an infection - but most people didn't end up with an infection diagnosis reflecting the heterogenous population tested.
I suspect there are lots of ways to make this better - some the technology & some the targeting to correct populations.