alexludwig.bsky.social
Cell biologist and nature lover interested in epithelial cell junctions, mechanobiology, and cell polarity. Asst Prof at NTU Singapore.
Check out the ALab homepage:
https://blogs.ntu.edu.sg/alabntusg/
30 posts
1,164 followers
602 following
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You don’t have to be German to know what this means - it’s clear as mud - and it’s disgusting
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Beautiful! Great work
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Would love to be added here - thank you!
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Oh wtf
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oh... what happened here? why overlapping holes? two grids on top of each other?
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:( I know. Never give up!
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thank you!
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great! could you add me please?
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Great! Could you add me please?
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thank you!
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3) we have interesting new data on the functions of the Homer proteins in epithelial cells (which we recently identified to interact with the Crumbs complex), and we have news on how apical proteins are trafficked during epithelial lumen formation. All unpublished - stay tuned!
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2) Using time-resolved proximity proteomics with APEX2 we have identified a membrane tension-sensitive caveolin-1 interactome that is likely to be important for the function of caveolae at the rear of migrating cells. elifesciences.org/articles/85601.
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Our data indicate that ARHGAP12 suppresses the activity of N-WASP to dampen actin assembly via Arp2/3 complex. This limits junctional tension and makes tight junctions more leaky. The story is currently under revision. Thanks to the two reviewers who have been very kind to us!
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Some recent highlights from the lab: 1) In a recent preprint we have identified a molecule (ARHGAP12) that controls the junctional actin cytoskeleton to regulate the paracellular flux of small macromolecules across tight junctions. doi.org/10.1101/2024...
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Beyond the ordinary repertoire of cell biological and biochemical approaches, we use various imaging techniques (incl. EM+CLEM) and proximity proteomics (our favourite tool is the APEX enzyme). We have also established zebrafish models in the lab, which I'm very excited about.
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My lab is interested in anything to do with cell polarity and cell-cell junctions. We currently focus on the organisation and regulation of tight junctions and the functions of the Crumbs polarity complex in epithelial tissue morphogenesis. We also have a long-standing interest in caveolae.
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Please add me - thank you
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Please add me here too :)
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Would love to be part of the group. Thank you
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Thank you so much! Would love to be part of the group
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Great - thanks Guillaume
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Nice! Would love to be included. Thanks!