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aweinstock.bsky.social
Immunologist interested in obesity and its related inflammation, macrophages, immune progenitors and more @UChicagoMed (weinstocklab.owlstown.net)
63 posts 931 followers 91 following
Prolific Poster

Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them! @standupforscience.bsky.social

I can't be more excited to be calling this inspiring scientist my colleague and neighbor 🎉🎉🎉🤩🤩🤩

#WeekendRead! #WeAreWhatWeEat! Lesbats, Garaude &co show @nature.com that macrophages recycle phagocytosed bacteria to fuel their metabolism but that dead, compared to live, bacteria still feed macrophages but reduce the induction of ROS & the secretion of IL1b! www.nature.com/articles/s41...

STAND UP FOR SCIENCE, Chicago March 7, 12-3pm Federal Plaza (211 S Clark St) standupforscience2025.org/chicago-il/

Abstracts for #METPHYS2025 are due this Friday! There are multiple short talks available! FEB28 is also the deadline for the Vanderbilt Vibrant program This initiative will provide several awards of $2000 to help new investigators attend www.sablesys.com/metphys2025-...

I appreciate this response from Ed Yong on why he requests that people mask at his events. www.nytimes.com/2025/02/22/m...

🚨PA colleagues: "Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania." "If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC Get out your Other Support and share that info!

#WeekendRead. #ImmunometabolismPower! Rodriguez Colman &co show @cp-cellmetab.bsky.social that lactate maintains stemness of #cancer cells to favor tumor growth by acetylation & epigenetic activation of MYC! #ScienceSavesLives dlvr.it/THwCvc

Disease diagnostics using machine learning of B cell and T cell receptor sequences www.science.org/doi/10.1126/... TL;DR: BCRs ARE ALL YOU NEED! (Well actually .... keep reading) 1/

Here, we go. Starting 2025 best lung papers. Will add as I go along and also updated on the blog. payalyokota.com/lung-macroph...

Oh no, it's Friday

Congratulations to Dr Eden Faneuff for her great thesis defense. Her accepted paper will be out soon!!!

Introducing the Adipose Tissue Knowledge Portal integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men @cp-cellmetabolism.bsky.social @ki.se www.cell.com/cell-metabol...

Anyone interested in physiological metabolism should follow @danieljdrucker.bsky.social - really insightful posts on diabetes, obesity and other metabolic diseases Glad to see him in the good platform 🙂

These are challenging times for science, but I'm happy to share a bright moment: our work is on the cover of Cell today. We built a compendium of human gut microbiomes integrating 168K worldwide samples, revealing patterns of microbiome variation across the globe www.cell.com/cell/current...

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.” I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

We have to fight now for research that we know benefits all of humanity, we have to stand up for our colleagues at the NIH, we can’t lie down and take it, we stand against this madness #standupforscience2025

Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...

#WeekendRead. #LiveForever. Lantz, Thorp &co show @cp-immunity.bsky.social that in neonatal, not adult, macrophages efferocytosis following heart injury leads to the production of throboxane, that acts on cardiomyocytes promoting proliferation & repair. #ScienceSavesLives

Today, send a note to your NIH program officers to thank them for the amazing work they have done to support your research. They have been critical in making this country a leader in life sciences. Do it now.

Bluetorial: The rationale for the “NIH” indirect cost “plan” is based on misunderstood (unintentional or intentional) accounting and math The value of real government transparency

#girl #women #diversity #science 💪💪💪 All these words banned from NIH apps are celebrated in the Weinstock lab #ProudMentor

Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH. Very thorough and clear. If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this... www.aau.edu/key-issues/i...

How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.

Government isn't a business. The goal isn't to save money. Success isn't measured by budget surplus. The goal is to spend money, investing in society. Every dollar spent on education, healthcare, and science is an investment in our collective wellbeing.

#WeekendRead! #LipidPower! @miriammerad.bsky.social &co show @natimmunol.bsky.social that to get activated, #DCs steal from cell debris & produce their own cholesterol which is organized in plasma membrane lipid nanodomains! AXL reduces this process & its deletion augment anti-tumor immunity!

#ScratchingIsGood… sometimes! @danhkaplan.bsky.social Liu &co show @science.org that the itch-scratch cycle drives a neuropeptide from pain-sensing neurons which further activates antigen-stimulated mast cells, favoring neutrophil recruitment & enhancing protection against Staph skin infections!

New review out spearheaded by Amanda Doran. This one is comprehensive review of the bone marrow niche in CVD and will be one of those I refer back to often. The figures are beautiful too. www.ahajournals.org/doi/10.1161/...

A soft, small, hopeful thing.

Submitting an NIH grant right now

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.

Why compete when you can collaborate?! Everyone wins with less stress. I wish it was like this all the time

Use the Human Microbiome Compendium data! We made the data and code available, & created a website and R package to navigate the compendium. Links: - Website: microbiomap.org - Data: zenodo.org/records/1373... - R package: blekhmanlab.github.io/MicroBioMap/ - Code: github.com/blekhmanlab/...

This primer aims to close gaps in understanding functional genomics study design by providing an accessible, math-free resource. It’s designed to encourage early, thoughtful planning for functional genomics experiments, even for those with no prior background in statistics. shorturl.at/eVa1w

The Early Bird Deadline for METPHYS2025 is Jan 31! This year @lucidsci is providing 3x $750 travel awards to outstanding trainees & the Vanderbilt Vibrant Program is providing up to 10x $2,000 travel awards to eligible persons www.sablesys.com/metphys2025-... redcap.link/Vibrant.MetP...

Amazing findings by our favorite microbiome neighbours! Check out regional differences in gut microbes and much more here 👇

Bluetorial-A dream and a bit of a nightmare Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.

www.nature.com/articles/s41... very interesting on real world changes in disease risk from taking GLP-1 receptor agonists. As effect estimates get more precise, this may be useful to benchmark genetic strategies for predicting obesity mediated disease risk.

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

So grateful for my (8!) amazing colleagues who read my entire grant proposal and trashed it without filters in my presence. They had awesome suggestions and now I have to rewrite it. This is the true academic language of love 🥰🥰🥰

#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance

Why is having a junior faculty mentor (with a senior mentor, of course) still a major criticism for postdoc fellowships?! 😤 Many junior faculty put immense effort into training, and have more time to do it since they're not travelling and often lighter on admin responsibility #newPI