cosimocommisso.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

80% of pancreatic cancer research comes from the federal government—funding that’s now at risk. Don’t let progress stop. 🚫💜 Tell Congress: Protect and increase research funding NOW! Take two minutes to message your members of Congress and share why this matters to you. p2a.co/PDtC4d7

submitted 5 days ago • 0 comments

Join us on March 12 at 2pm ET for our webinar on Pancreatic Cancer Risk Factors & Screening. With pancreatic cancer set to become the 2nd leading cause of cancer deaths by 2030, early detection is critical. Learn from Dr. Raymond Wadlow & patient advocate Andy Lyons. Register now!

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Important article by Pete Shultz about how NIH cuts will impact biomedical research in San Diego and beyond www.sandiegouniontribune.com/2025/02/25/o...

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Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives. An assault on science anywhere is an assault on science everywhere; the global community must unite 🧪 www.nature.com/articles/d41...

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Important article by Pete Shultz about how NIH cuts will impact biomedical research in San Diego and beyond www.sandiegouniontribune.com/2025/02/25/o...

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Special Conference | “Metabolic Stress and the Tumor Ecosystem: New Paradigms for Tumor Progression and Therapy” a conference by Cosimo Commisso. 📅 Tuesday, March 11 at 11 a.m. at the IRCM and online 🔗Learn more: bit.ly/4gVKbVm Not to be missed! @cosimocommisso.bsky.social

submitted 7 days ago • 0 comments

I keep thinking about the campaign slogan "We Are Not Going Back," which I didn't like....but it turned out to be prescient. As in Orwellian 1984. A tough road ahead to get us back on track. But we will. #standupforscience2025

submitted 7 days ago • 21 comments

🚨This should be amplified!! Study sections and council meetings are still being cancelled despite the court order unblocking NIH freezes, effectively halting any new research grant from being funded: www.thetransmitter.org/funding/fede...

submitted 11 days ago • 2 comments

The Paul Marks Prize for Cancer Research recognizes a new generation of leaders in cancer research who are making significant contributions to the field through basic or clinical research. Know someone who fits the bill? Nominate them for the 2025 prize. bit.ly/3ETXE2I

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Our CEO, Eric Verdin answered questions about the administration’s proposed budget cuts to the NIH at a hearing before the Senate Special Committee on Aging this afternoon. Hear his exchange with Angela Alsobrook D-MD here: youtu.be/XrhHldez1AI

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Have you called your congressional office yet today about the NIH cuts to research? The person I spoke to didn't know what I was talking about. We have more work to do!

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"The indirect cost rate is calculated based on historical costs...carefully evidenced through established accounting practices...[it] is not expected to be uniform due to regional variations in prices and activities" scholarlykitchen.sspnet.org/2025/02/10/n...

submitted 21 days ago • 1 comment

📢 NIH funding has been the backbone of groundbreaking discoveries—from basic biology to lifesaving cancer treatments. But with recent attacks on research funding, our ability to innovate and cure diseases is at risk. goodscience.substack.com/p/indirect-c...

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Trying to focus on inspiring activities… join us for 3rd annual SoCal Metabolism Symposium this year hosted by @petemullen.bsky.social at USC in Los Angeles. gero.usc.edu/event/third-...

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Now online in Cancer Discovery: Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression - by Kathrina Oñate, @marasherman.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social

submitted 24 days ago • 0 comments

I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field. www.cancermetabolismshowcase.org

submitted 39 days ago • 0 comments

Just returned from a wonderful visit to the University of British Columbia in beautiful Vancouver where I had the honor of delivering a seminar. A heartfelt thank you to my gracious host, Dr. Janel Kopp. I was also thrilled to catch up with Dr. Seth Parker, Ph.D. and @tanentzapflab.bsky.social.

submitted 41 days ago • 0 comments

Activity-based sensors identify cuproplasia and ferroplasia as druggable metal vulnerabilities in cancer! With @ginadenicola.bsky.social and Adam Renslo, we profile cancer cell lines to find those sensitive to Cu or Fe chelation www.pnas.org/doi/10.1073/... www.pnas.org/doi/10.1073/... #chemsky 1/n

submitted 45 days ago • 1 comment

Our lab's first paper of 2025. With @christhechang.bsky.social we find that NRF2 active lung cancer cell lines suppress labile copper and are vulnerable to copper chelation (1/3).

submitted 42 days ago • 5 comments

Today we celebrate Zena Werb with an inspirational memorial lecture delivered by @carolynbertozzi.bskyverified.social who is a former UCSF Dept of Anatomy postdoc alum !

submitted 47 days ago • 2 comments

Lots of press📰 on a bioRxiv study: 30% men, 40% women stopped publishing after 5 yrs; reasons not explored. Some press called it "leaving science" or "quitting". Many are advancing science in industry, clinic, etc. They didn't quit. Let's address inequities without assuming or stigmatizing.

submitted 51 days ago • 0 comments

🔬🩺 Breakthrough: Enzyme MICAL2 identified as key driver in pancreatic cancer progression, offering new hope for targeted therapies.

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Ludwig @harvard.edu’s @alextoker.bsky.social discusses his work, what drew him into a life of science and what compels him to contribute to cancer research. youtu.be/IIG5VD8EHB8 #CancerResearch #CancerChat #ImmunoSky

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@ucsdmedschool.bsky.social researchers have identified a key enzyme that promotes the growth and spread of the most common form of pancreatic cancer. @CR_AACR today.ucsd.edu/story/enzyme...

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New preprint from the lab just posted to bioRxiv. Our first foray into antisense RNAs, led by postdoc Manon Chadourne, with implications for mRNA translation. Great collab with Alex Jaeger and his lab!

submitted 66 days ago • 1 comment

🎄✨ Happy Holidays from the Commisso and Emerling labs! ✨🎄 We had an amazing time at our annual Christmas outing, celebrating another year of science, teamwork, and friendship. Wishing everyone a joyful holiday season filled with happiness, laughter, and some well-deserved rest. 🎅🔬❄️

submitted 73 days ago • 1 comment

Join us for the final TPD webinar of 2024 on 12/19. @fleurmferguson.bsky.social & Eric Wang - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"

submitted 75 days ago • 0 comments

Excited to share our new opinion piece in Trends in Cancer: “A hormetic response model for glutamine stress in cancer.” Shout-out to grad student Shea Grenier for leading this bold work! Dive into the complexities of glutamine metabolism and cancer here: www.sciencedirect.com/science/arti...

submitted 76 days ago • 0 comments

@robzonculab.bsky.social lab representing at #CellBio2024 San Diego - great talks in the #Lysosome session by @hrshin.bsky.social @cri-utsw.bsky.social and @aakritijain.bsky.social 🙌 Lysosomes are amazing !

submitted 77 days ago • 0 comments

In case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy. www.biorxiv.org/content/10.1...

submitted 81 days ago • 0 comments

Congratulations to the new #AACR #TME working group Chair elect!!! The one and only (best friend and colleague) @ashi-w.bsky.social www.aacr.org/professional...

submitted 81 days ago • 4 comments

The #TME torch has been passed to yet another fearless and inspiring leader!

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On December 6, we remember: Geneviève Bergeron Hélène Colgan Nathalie Croteau Barbara Daigneault Anne-Marie Edward Maud Haviernick Maryse Laganière Maryse Leclair Anne-Marie Lemay Sonia Pelletier Michèle Richard Annie St-Arneault Annie Turcotte Barbara Klucznik-Widajewicz

submitted 87 days ago • 0 comments

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer #PancreaticCancer 🧪 biorxiv.org/cgi/content/...

submitted 87 days ago • 0 comments

#Weekendreading Terrific study by the amazing @cosimocommisso.bsky.social and his super talented team and colleagues 💜 showing how #macropinocytosis modulates pro- #pancreaticcancer #CAF function in the #TME

submitted 87 days ago • 0 comments

🚨 New bioRxiv study! 🚨 PDAC adapts to glutamine depletion via macropinocytosis, reshaping CAF subtypes & tumor stroma. Blocking it sensitizes tumors to therapy. Shoutout to Dr. Yijuan Zhang for leading this amazing work! Read more: 🔗 www.biorxiv.org/content/10.1... #CancerResearch #PDAC #TME

submitted 87 days ago • 1 comment

Hey scientists - another incentive to share your research articles here on bluesky 😁😁😁💪💪💪❤️

submitted 89 days ago • 0 comments

I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities. www.nature.com/articles/s41...

submitted 89 days ago • 4 comments