davidesanin.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)

submitted 5 days ago • 68 comments

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.” I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

submitted 6 days ago • 46 comments

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n

submitted 8 days ago • 8 comments

Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social (I sure needed an injection of great science in these times) @mathcancer.bsky.social closing out the show...

submitted 12 days ago • 0 comments

I'm co-organizing a Cell Symposia on Metabolites in Organellar Communication with @robzonculab.bsky.social, Kivanc Birsoy, and Allyson Evans (@cp-cellmetabolism.bsky.social). It will be in Sitges May 11-13. Submit an abstract by Feb 14. Hope to see you in Spain! cell-symposia.com/metabolites-...

submitted 12 days ago • 0 comments

Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH. Very thorough and clear. If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this... www.aau.edu/key-issues/i...

submitted 13 days ago • 5 comments

The #SACB2025 immunology session closes out with @davidesanin.bsky.social discussing myeloid cell regulation in prostrate cancer

submitted 13 days ago • 0 comments

Enjoying day one of #SACB2025! Amazing line up of speakers today!! Good reminder of the amazing communities of scientists using all kinds of tools and working towards helping patients with cancer!

submitted 13 days ago • 0 comments

How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.

submitted 14 days ago • 10 comments

submitted 14 days ago • 1 comment

Interesting (and thorough) demonstration that tissue resident macrophages (at least Alveolar ones) can be far from their niche for a VERY long time and still retain their identity when they get back! Also remarkable epigenetic and transcriptional plasticity! Cool paper!!! rdcu.be/d8BBH

submitted 20 days ago • 0 comments

Asteroid fragments upend theory of how life on Earth bloomed Samples from Bennu contain the chemical building blocks of life — but with a twist. www.nature.com/articles/d41...

submitted 22 days ago • 1 comment

My lab studies how immune cells use the nutrients to effectively combat diseases. We proudly collaborate with a large group of clinicians and other researchers to advance therapies to treat metastatic prostate cancer. A terrible disease that kill thousands of men every year. Help us help them!

submitted 29 days ago • 0 comments

More than ever, researchers need to explain how they use taxpayer money to provide tangible benefits. I'll start: My lab has developed a completely novel way to make cellular therapies a lot more effective. Our approach shows promising results in pancreatic, ovarian and lung cancer.

submitted 29 days ago • 16 comments

Really interesting paper 🧪 🤩 Immune evasion through mitochondrial transfer 😮 Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity www.nature.com/articles/s41... www.nature.com/articles/d41... @nature.com

submitted 32 days ago • 42 comments

Exploring Augur!! Such a cool tool to run an unbiased exploration of the effect of a treatment at the single cell level! Also very important discussion around the effect of cell number on the apparent number of DEGs detected! rdcu.be/d64P8

submitted 33 days ago • 0 comments

A favorite commission this year, a dividing cell with an extra detail. Colleagues of a retiring researcher commissioned me to add the specific structure she worked on—the spindle pole body—to the sculpture. Here it is close up, in sterling silver embedded in the bronze nuclear membrane. 🔬#SciArt

submitted 58 days ago • 65 comments

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

submitted 63 days ago • 6 comments

We were seeing a 98% drop in exposure over on Twitter. The censorship was so extreme we thought it best to start over somewhere else. We chose Bluesky. Help us gain our following back Follow Retweet Repeat Join the park side @altyellonatpark.org

submitted 65 days ago • 860 comments

Such a cool paper showing how NAD+ pools interact with one another and how the mitochondrial NAD+ pool is a rheostat for the cell! Incredible tools here! rdcu.be/d3O14

submitted 69 days ago • 0 comments

Woo hoo! Our latest neoadjuvant clinical trial results are out! www.cell.com/iscience/ful...

submitted 71 days ago • 0 comments

Celebrating Christmas with my lab!

submitted 73 days ago • 0 comments

submitted 73 days ago • 1 comment

Happy to share an educational case that demonstrates that selection can drive acquired therapy resistance in metastatic prostate cancer rdcu.be/d15Ph Wonderful collab with @rachelkarchin.bsky.social @davidesanin.bsky.social

submitted 77 days ago • 0 comments

Really cool paper delving into the way macrophages limit the effectiveness of ICB therapy in prostate cancer!! rdcu.be/d2MPC

submitted 79 days ago • 0 comments

A common question nowadays: Which is better, diffusion or flow matching? 🤔 Our answer: They’re two sides of the same coin. We wrote a blog post to show how diffusion models and Gaussian flow matching are equivalent. That’s great: It means you can use them interchangeably.

submitted 84 days ago • 7 comments

Hopkins faculty: Need editorial assistance for a proposal or an article? Make use of our services at no charge. Contact my office here: research.jhu.edu/rdt/easi/ Happy writing!

submitted 83 days ago • 2 comments

Methods for exploring the geography of molecular-scale processes within tissue samples are transforming cancer research, but the toolbox can be daunting. Read the Nature technology feature. 🧪

submitted 87 days ago • 0 comments

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity 🧪 www.cell.com/cancer-cell/...

submitted 94 days ago • 0 comments

Will be interesting to find out how IMI (intrinsic molecular identifiers) will perform vs UMI in scRNAseq data! Specially with the issues like dropout and zero-inflation that UMIs correct for! www.biorxiv.org/content/10.1...

submitted 96 days ago • 0 comments

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. www.nature.com/articles/d41...

submitted 96 days ago • 3 comments

Would love to build this out!! Let me know if you want to join!

submitted 96 days ago • 1 comment

Interested in #singlecell and #spatial #metabolomics? Then book your calendar for December 10th! – Our online, free event will summarize major achievements of the field in 2024. #metabolism #omics #MALDI #EPFL With Giovanni D'Angelo and our #PhD students we prepared for you a fantastic lineup. 🧵 1/5

submitted 97 days ago • 2 comments

Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors doi.org/10.1016/j.cr...

submitted 100 days ago • 5 comments

Post a picture you took (no description) to bring some zen to the timeline

submitted 100 days ago • 0 comments

Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...

submitted 100 days ago • 1 comment

The slide that you insist on keeping even though it'll make your presentation go over time

submitted 100 days ago • 5 comments

Excited to announce my move to a new role as Director of @genomescience.bsky.social at University of Maryland starting in Dec! www.medschool.umaryland.edu/news/2024/le...

submitted 101 days ago • 64 comments

So cool! Understanding how mtDNA regulates their movement inside cells will be possible with tools like these!

submitted 101 days ago • 1 comment