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davidusharauli.bsky.social
Immunologist & biotech startup co-founder (tregeutix.com) on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey 🚀
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"The intelligence community also determined that, in the autumn of 2019, three of Shi’s researchers fell ill with COVID-like symptoms." #covid19 #lableaktheory

"Stopping renewals of Title 42 employees would be devastating to the intramural research program and to #NIH as a whole” "staff scientists, research fellows, and tenure-track investigators, most of whom are hired under a statute known as Title 42."

"G+ index’ — G representing generosity, giving, and other ‘good things’ in academia." I thought this person had just woken up from hibernation but close, they’re writing from Australia. #science #NIH

What you see is the top of a fence. In western Georgia, the snowfall is too great. Families are trapped without heating, electricity, and food supply for days now. An elderly home asks for a rescue. The regime’s resources are fully immersed in hunting peaceful protesters though.

I found a Science news & comments article from 1983 titled 'NIH Seeks Reduction in Indirect Costs.' Seems like this fight has been going on for 40 years. @NIH #NIH #science

"it appears that in vaccinated adults (without reference to any high-risk subgroups) that Paxlovid is not making much of a difference at all" #paxlovid

The Weekend Tunes Papi Hans - Song for Her (🇧🇬 Bulgaria) A touching ballad about a lost love that will never return. [Once she says "no" it's a "no". She's stubborn like a child. And when she says "no" it's ay-ay-ay-ay-ay-ay, Ay-ay-ay "no"] www.youtube.com/watch?v=y0LF...

Late yesterday, Trump issued an executive order that terminates HHS's Long COVID advisory committee. The committee's focus was bringing perspectives from outside government to inform action of the Executive Branch on Long COVID and other infection-associated chronic conditions.

A bit of amusing news about Georgia too. Stay tuned for the establishment of the dictatorship and the Georgian resistance though.

Sequence clustering confounds AlphaFold2 "This demonstrates conclusively that AF-cluster lacks predictive and explanatory power." #science #AI

"Despite the GZMB reactivity against multiple neoepitopes, the patient’s disease progressed, suggesting underlying mechanisms of immune failure" This remains a key unresolved question that current models of the adaptive immune system struggle to explain.

Wait, is the whole Gordon Research Conference #GRC for #SexDifferencesInImmunity just ... gone? Understanding the fundamentals of sex differences contributes to precision medicine. It helps everyone. Eliminating this meeting or targeting these scientists harms everyone.

The Weekend Tunes Nutsa Topuria - 'gift' in Abkhazian (🇬🇪 💔) Nutsa sings an Abkhazian song (originally by Saida Gabnia). Abkhazia, a region in the western Caucasus, was once part of Georgia but is now under Russian occupation. youtu.be/LvZ5irKUPQ8?... youtube.com/watch?v=mDPf...

Since the MYD88/TRIF double knockout debacle 15 years ago, which revealed that their absence doesn’t impact antibody production, the entire adjuvant field has collapsed. You can't fit a square peg into a round hole. #immunology

CDC source: “We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff. They are calling this ‘Phase 1’.”

The National Institutes of Health and some VA regions are scouring existing grants using lists of flagged words, which include not just known trigger words for the Trump administration — trans, nonbinary, and diversity — but also “women” and “Covid.”

There hasn’t been an NIH-related post since 1/21. Despite seeing upcoming study section & council dates in eRA commons, these will not take place if they weren’t announced. They’re starving us out until the next budget unless Universities step WAY up.

1/ Generally speaking, reviews that only compile existing experimental results without contributing theory, hypotheses, unpublished data, or personal communications are unproductive and merely serve to pad one's CV or ego. #science #review_article #immunology

"That may mean laying people off and maybe putting hiring freezes on new faculty," he says. "We will have to make up for the difference through cost cutting in some way.’ #NIH #science

A new book is coming out about how fraudulent data supporting the amyloid hypothesis derailed Alzheimer’s research for two decades, squandering vast amounts of biotech and academic funding. #Alzheimer #science #fraud

A Dapl1+ subpopulation of naive CD8 T cells contains committed precursors of memory lineage doi.org/10.1101/2025...

instances of #GIGO (Garbage In, Garbage Out) data statements: 1. "Each unique motif is represented by a term in these models whose coefficient indicates the extent to which that motif contributes to predicting accessibility changes" #science 🤔

NIH radically cuts support to universities. The sudden & drastic $4B cut will make it hard for rsrchrs to keep the lights on & will have devastating consequences for medical rsrch, particularly in critical areas such as cancer, heart disease, & infectious diseases. arstechnica.com/science/2025...

The next @NIH memo may recommend using Sci-Hub, LibGen, Anna’s Archive, or the Telegram Nexus bot to access research papers, citing the high costs of journal subscriptions and open-access fees. Technically, their point about the fees would be valid. #NIH

#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through science

The Weekend Tunes Avaz Akimov & Aydana Deka - Gülüm Ay (🇰🇬 Kyrgyzstan) This is a remake of a 1992 disco/pop song by Bek Borbiev & Asel Turdalieva that was popular in 1990s Kyrgyzstan. https://www.youtube.com/watch?v=6ur_wkcjVP0&ab_channel=AvazAkimov

1/ Another rollercoaster of a paper on Foxp3+ Tregs, this time from Rudensky’s lab. It took over two years to get published, and I wouldn’t be surprised if some well-placed "connections" helped push it through. #immunology #science #Foxp3 #Tregs #ImmunoSky www.nature.com/articles/s41...

"Indo–European tongues originated from the Caucasus mountain region."