drharrycostello.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

What symptoms do people tell their GP about when they are developing dementia? Lots of non-cognitive symptoms - and in a highly diverse population we can see that it is culturally influenced. Recognising this is key to equitable diagnosis alz-journals.onlinelibrary.wiley.com/doi/full/10....

submitted 2 days ago • 2 comments

FDA removes risk evaluation and mitigation for clozapine, including neutrophil monitoring www.fda.gov/drugs/postma...

submitted 2 days ago • 1 comment

When I worked in UK academia I recall hearing of a Japanese man who was baffled at how Britain had decided to run its universities like firms. “Why? Your universities are excellent and your firms are terrible.”

submitted 2 days ago • 21 comments

Psychiatrist Allan House was permitted, like me, to speak to the assisted dying committee - but only after it first tried to ban @rcpsych.bsky.social’s testimony. Pls read his letter. How is the committee remotely serious about protecting the vulnerable if it dismisses the doctors who treat them?

submitted 10 days ago • 8 comments

There is evidence that Gardisil has largely eliminated cervical cancer in highly-vaccinated populations. Couldn't agree more with @drneilstone.bsky.social academic.oup.com/jnci/article...

submitted 11 days ago • 3 comments

Terrific piece about the challenge facing Europe and what we must now do in this weekend's @financialtimes.com:

submitted 12 days ago • 12 comments

Medication Treatment Challenges in Mood Disorders: A Discussion with Jim Phelps Reevaluating the emphasis on efficacy vs risks www.psychiatrymargins.com/p/medication...

submitted 12 days ago • 1 comment

Will we choose to – divide et impera – divide and conquer, or will we continue to clump all cases of Parkinson's? Substantia nigra and locus coeruleus are early brain regions affected by PD? These regions are important to learning and cognitive (thinking) functions, but in very different ways.

submitted 13 days ago • 0 comments

1/3 Tutorial on exploring ecological momentary assessment data is online at AMPPS, with: - Accessible ways to visualize data for better understanding - Models to get some first insights - Further reading boxes for more advanced topics - Reproducible pipeline you can run over your own data

submitted 15 days ago • 6 comments

this is super interesting... nice work!

submitted 16 days ago • 0 comments

www.nature.com/articles/s41... an inexpensive, simple method for breathing out alcohol effectively w/o hyperventilation, to get sober quicker

submitted 17 days ago • 0 comments

In this ancient Assyrian letter, astronomers complain that they can’t do their jobs or teach astronomy “because of the ilku-duty”, a type of taxation in the form of labour. “we cannot keep the watch of the king, and the pupils do not learn the scribal craft” cdli.mpiwg-berlin.mpg.de/artifacts/33...

submitted 18 days ago • 15 comments

Anatomy of Moncrieff's Anti-Medication Playbook A 3-step strategy of attacking medical psychiatry www.psychiatrymargins.com/p/anatomy-of...

submitted 19 days ago • 0 comments

🚨🚨New pre-print!🚨🚨 Check out our latest work, where we focus on the effects of LSD and MDMA on a so-far somewhat neglected (but important) set of brain hubs - the striatum. Led by the very excellent Natalie Ertl and a couple of undergraduate students. www.biorxiv.org/content/10.1...

submitted 19 days ago • 1 comment

come and work in the UCL Neuroscience & Mental Health group, with @olijrobinson.bsky.social!

submitted 21 days ago • 0 comments

Phase IIb trial of 5-MeO-DMT in depression reports big results: -15.5 MADRS reduction -57% remission by day 8 But where has the placebo response gone? Barely there: 0% remission, +0.3 MADRS at day 8. 🤔 investor.ghres.com/news-release...

submitted 20 days ago • 0 comments

The first phase III trial of a #GLP-1 drug (Exenatide) for a neurodegenerative disease (#Parkinson's disease) found no effect: www.thelancet.com/journals/lan... Epidemiological studies had shown large effects. Potential implications for the repurposing of GLP-1 drugs in other conditions?

submitted 23 days ago • 0 comments

Thanks to all who came to support and watched online! A recording is available here: www.youtube.com/live/6LSfkQk...

submitted 31 days ago • 4 comments

I can be as critical as anyone of the government's occasionally muddled message on growth but Look! At! This! Chart!! Anything they've done pales next to this GIGANTIC UNFORCED ERROR COMMITTED IN 2016! (fagpacket maths follows) on.ft.com/4hzyvbJ

submitted 30 days ago • 41 comments

New from us, and first study from the PhD of Dr @elisavetpappa.bsky.social Delusional Themes are More Varied Than Previously Assumed academic.oup.com/schizophreni... A global meta-analysis of the prevalence of delusional themes in psychosis, examing association with clinical features and culture

submitted 30 days ago • 3 comments

A speculative take on the DeepSeek fiasco: Chinese firms, under resource constraints, will be more likely to build architectures and algorithms closer to what the brain implements (i.e., highly energy and data efficient learning/computation).

submitted 31 days ago • 3 comments

Our new paper. Why we should be suspicious of claims based on meaningful within-individual change from parallel-group trials of Alzheimer’s treatments. Avoiding causal fraud! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 31 days ago • 2 comments

One rule for #psychotherapy research, another for #pharmacology in #mentalhealth? How much of the psychotherapy evidence base would hold up to medication trial standards? Brilliant paper led by Prof Stringaris: mentalhealth.bmj.com/content/28/1...

submitted 35 days ago • 0 comments

That reassuring thump as the #weeklypapers arrive on your Bluesky doorstep. What’s caught my eye in #mentalhealth research and comment this week?

submitted 35 days ago • 1 comment

Where do the dopamine hits does from? A new reward center in the brain is discovered (yes, single cell, spatial omics at work again) @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

submitted 35 days ago • 3 comments

Check out this sweet new blog post from Julia, which also references one of my old blog posts (solomonkurz.netlify.app/blog/2022-06...).

submitted 36 days ago • 7 comments

Here is an important paper asking hard questions about psychotherapy and pharmacotherapy in the setting of youth depression treatments: mentalhealth.bmj.com/content/28/1.... Patients in medication trials are more severely ill; and the standard comparators in psychotherapy trials are easier to beat.

submitted 37 days ago • 1 comment

Thrilled to have our collaboration with Dr Laramie Duncan out in @natureneuro.bsky.social! We leveraged two landmark datasets (GWAS + snRNA-seq from 105 regions of human brain) to infer the cell types involved in the etiology of psychiatric phenotypes (SCZ, AUD, Sleep) www.nature.com/articles/s41...

submitted 38 days ago • 2 comments

This 👇👇👇. Every trust I’ve worked at has struggled to roll out in-house electronic prescribing and has either completely ignored or made electronic community prescribing seem like a distant dream. Why???

submitted 37 days ago • 1 comment

V interesting finding! Check this out

submitted 39 days ago • 0 comments

Completely agree with Luke's journey here. While there's much bad faith commentary from papers read by retirees and owned by those with commercial property investments, there's a huge amount lost if WFH becomes the default everywhere.

submitted 40 days ago • 3 comments

Shots fired! «There is no convincing evidence that long and intensive therapy [for personality disorders] is more effective than short and less intensive therapy.» journals.lww.com/co-psychiatr...

submitted 41 days ago • 1 comment

submitted 44 days ago • 0 comments

"“Let’s edit your baby’s genome and hope for the best” is not exactly a compelling marketing slogan. It’s certainly not a responsible medical attitude." This is a typically first-class analysis from @wiringthebrain.bsky.social. www.wiringthebrain.com/2025/01/euge...

submitted 45 days ago • 3 comments

Dummies Guide to “The British Professor Leading the Controversial Backlash Against Antidepressants” British journalists and editors, this is for you www.psychiatrymargins.com/p/dummies-gu...

submitted 45 days ago • 10 comments

I am delighted this work by @gerardosalvato.bsky.social et al on the relationship between disturbances in the sense of body ownership & temperature regulation is finally published! doi.org/10.1038/s414... Here is a thread on the long, scientific whodunit 1/11

submitted 48 days ago • 2 comments

Nice review highlighting the associations between neuropsychiatric conditions and #cerebrovascular deficits doi.org/10.1111/eci.... #BloodBrainBarrier #Psychiatry

submitted 51 days ago • 1 comment

Our review on the theoretical status of oscillations and field potentials is out! What are their effects, and what can electrophysiology signals reveal about how the brain works? w/ @dlevenstein.bsky.social @prokraustinator.bsky.social Bradley Voytek @rdgao.bsky.social www.cell.com/trends/cogni...

submitted 53 days ago • 1 comment

Fascinating #Nature study highlighting the importance and predictive power of personalized set points rather than one-size-fits-all reference intervals for blood counts. Potential implications for #Clozapine monitoring in #psychiatry? www.nature.com/articles/s41...

submitted 53 days ago • 0 comments

Excellent review paper (by @rob-mccutcheon.bsky.social @mattnour.bsky.social & others) Clearly lays out the historical challenges and future frameworks to guide drug development in psychiatry. www.biologicalpsychiatryjournal.com/article/S000...

submitted 56 days ago • 0 comments

Striatal stimulation enhances cognitive control and evidence processing in rodents and humans www.science.org/doi/10.1126/... #neuroscience

submitted 57 days ago • 1 comment

How can sharing our uncertainty with others alter our confidence when we're alone? Delighted to share the lab's new paper, with Einar Andreassen and @cdfrith.bsky.social. Particularly pleased as it's Einar's first! Link: osf.io/preprints/ps... 🧵👇 #PsychSciSky #neuroskyence

submitted 57 days ago • 1 comment

1. New big meta-analysis on interventions for treatment resistant depression. Important work! Below I pasted the main result. You can see that ECT favors best. I was mainly interested in (es)ketamine and after a closer look I found some oddities www.nature.com/articles/s41...

submitted 58 days ago • 6 comments

Do you know about PIEZO receptors? We're learning more about their expansive role every day. A new podcast (with transcript and full video) with @ardemp.bsky.social, my friend and colleague @scripps.edu, who discovered these channels erictopol.substack.com/p/ardem-pata...

submitted 60 days ago • 10 comments

Another trial indicating that eye movements doesn’t contribute to outcomes of EMDR. bmcpsychiatry.biomedcentral.com/articles/10....

submitted 61 days ago • 3 comments

Another paper that had a big impact on my thinking in 2024: a meta-analysis showing that behavioral change interventions targeting HABITS may be more effective than those targeting knowledge/beliefs/attitudes (@natrevpsych.bsky.social again!). Habit really matters! #psychology (a short 🧵1/3)

submitted 62 days ago • 7 comments

www.thelancet.com/pdfs/journal... which is the best treatment for adult ADHD ?

submitted 61 days ago • 0 comments

Au contraire. LLMs show why Kant was right and Hume was wrong: you don't get causal understanding just from predicting correlations (and they don't even strictly speaking predict anything; we use them to do that). www.cell.com/trends/cogni...

submitted 62 days ago • 6 comments