karimaj.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

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I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...

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RNA xkcd.com/3056

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Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response

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While artificial intelligence and quantum computing insiders have both been guilty of hyping up their products, only the latter group appears to still be applying proper scientific rigour to their field

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In 2017 I had the absolute privelege of hearing a plenary by Sean B Carroll at #Dros17. He told the story of Albert Camus and Jacques Monod. In 1940 occupied France, Monod pursued his Nobel-winning research by day & resistance by night. Read "Brave Genius": www.seanbcarroll.com/brave-genius... 1/2

submitted 20 days ago • 5 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

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Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

submitted 22 days ago • 3 comments

Very happy to see some of my unpublished PhD data (more than 10 years ago) eventually ending up in a paper ! Argonaute 2 targets viral transcripts but not genomes of RNA viruses during antiviral RNA interference in Drosophila. Congrats to Joao T. Marques, @cmeignin.bsky.social and all co-authors !

submitted 22 days ago • 1 comment

Check out our most recent preprint where we describe Mecp2 as a régulatrice of cGAS-STING associated signaling. 🧪🔥

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Happy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...

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www.forbes.com/sites/roncar...

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@irim-life.bsky.social @biolum-montpellier.bsky.social

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📢Job alert We have two postdoctoral positions available, starting in Spring 2025. These positions are part of research funded by an ERC Advanced Grant, focused on exploring evolutionary immunology (Evo-Immuno). #Postdoc #InnateImmunity Do not hesitate to contact us. ibmc.cnrs.fr/en/laboratoi...

submitted 43 days ago • 0 comments

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

submitted 36 days ago • 1 comment

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

submitted 35 days ago • 55 comments

A Boa Constrictor brain-derived cell stained for Actin ⚪, cell membranes🟣 and DNA 🔵. #FluorescenceFriday #sciart

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I am thrilled to share our latest work, released today 🤩 www-nature-com.insb.bib.cnrs.fr/articles/s41... It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.

submitted 38 days ago • 11 comments

It’s crazy how talking with a science buddy is simultaneously what’s most likely to move the project forward and the thing that’s least prioritized in our schedule.

submitted 65 days ago • 4 comments

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Anti-venom spat out of a computer ! Thank you David Baker !

submitted 44 days ago • 0 comments

BREAKTHROUGH REPORT: Super-resolution expansion microscopy in plant roots (Michelle Gallei, Sven Truckenbrodt, Caroline Kreuzinger, et. al.) https://doi.org/10.1093/plcell/koaf006

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Obituary for computational chemistry pioneer Martin Karplus in the New York Times (gift link). #CompChem #ChemSky 🧪 www.nytimes.com/2025/01/13/s...

submitted 46 days ago • 2 comments

A review on TLR4 and viral infections , I contributed to with eric Kremer’s lab and Fabien Blanchet ! @cp-trendsmicrobiol.bsky.social

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For those wondering, epsiloncoronavirus has already been described (www.sciencedirect.com/science/arti...). It’s from European badgers and related to Zeta, but distant enough to be a new genus. Not clear if segmented. So, there’s huge untapped diversity out there.

submitted 48 days ago • 0 comments

www.nature.com/articles/s41...

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A monolayer of Boa Constrictor 🐍 cells stained for Actin 🔵 and DNA 🟠 #FluorescenceFriday #sciart

submitted 49 days ago • 3 comments

I released the LUT finder: A plugin to see all your ImageJ / Fiji LUTs in a table with previews, auto generated descriptions and filtering! You can try it with the KTZ_LUTs update site or from github.com/kwolbachia/L.... I'm looking for your feedbacks! #FluorescenceFriday #MicroscopyMonday

submitted 50 days ago • 2 comments

RNA control of reverse transcription in a diversity-generating retroelement www.nature.com/articles/s41...

submitted 51 days ago • 2 comments

Finally, some good news!

submitted 51 days ago • 1 comment

Joe is my favorite microscopist - artist, so lucky to have him in our lab @viroscope.bsky.social 😊

submitted 55 days ago • 1 comment

To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below. www.nature.com/articles/s41...

submitted 57 days ago • 3 comments

A Boa Constrictor cell issued from a brain-derived culture, with actin in yellow and DNA in pink. Check out those crazy stress fibers! #FluorescenceFriday #sciart

submitted 57 days ago • 1 comment

Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 https://buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling

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