markjamesadams.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

💫Wanted: a 3-year postdoctoral fellow interested in epigenomics, lifecourse health, and anti-poverty interventions — to be based in Berlin in the Biology, Social Disparities, and Development group led by @laraffington.bsky.social. postdocprogram.mpg.de/node/692

submitted 16 hours ago • 2 comments

"Why don't you buy a new centrifuge" Because everyone knows that any appliances in that shade of yellow will outlive you and your entire family, look at it

submitted 1 day ago • 73 comments

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

submitted 14 days ago • 1 comment

Mastodon threads with technical details of why PubMed is down for some but not others. Something is wrong with the NIH nameservers. tldr.nettime.org/@ww/11408991...

submitted 19 days ago • 1 comment

Exciting new role for a Computational Genomics Research Associate in the lab of @sj-marzi.bsky.social at the UK DRI at King's! Lead projects exploring the epigenome and transcriptome of brain cells in neurodegenerative diseases 🧠 🗓️ Deadline: 08 March 2025 Full info & to apply 👉 shorturl.at/fk7jS

submitted 22 days ago • 0 comments

1/ What do people perceive as causes for depression, poverty, & mortality—and are social or non-social causes more important? New preregistered study led by Emma Bridger in a n=1000 UK sample, including a wide variety of perceived causes. #episky #psychscisky #PublicHealth 🧪

submitted 22 days ago • 4 comments

Really excited to share our next population-scale WGS work preprint. Here, we analyse three anthropometric traits in nearly 700,000 individuals (discovery UKB ~450K, replication AoU). We show, for these traits, that common and rare variant heritability is convergent www.biorxiv.org/content/10.1...

submitted 23 days ago • 1 comment

"the random‐effect based test for multinomial logistic regression ... is not invariant to the choice of the reference level" This "can be problematic ... because researchers may draw potentially contradictory conclusions due to different choices of the reference level" DOI 10.1002/gepi.22427

submitted 23 days ago • 1 comment

Horicon National Wildlife Refuge, 2015

submitted 24 days ago • 0 comments

How does the quality of pedigrees impact genetic studies? Based on genealogical data, bigger and deeper pedigrees improve precision, but even small errors skew results! Our work highlights the need for careful sensitivity analyses: doi.org/10.1093/jeb/... @wmawass.bsky.social and E. Milot

submitted 24 days ago • 0 comments

Excited to finally share that our paper looking at the effect of rare non-coding variants using WGS on circulating protein levels in the UKB has been released in Nature Genetics @naturegenet.bsky.social! We now analyse the full 3,000 circulating proteins in all 50,000 individuals rdcu.be/ea16i

submitted 25 days ago • 1 comment

Our new methylation study of active antidepressant treatment, identifying hypermethylation at genes with roles in mitochondrial metabolism and neurite outgrowth. www.nature.com/articles/s41...

submitted 25 days ago • 0 comments

"Music To Refine To" youtu.be/JRnDYB28bL8

submitted 27 days ago • 0 comments

Fancy a 4-year post-doc in Cambridge, working in both the biggest biomedical centre in Europe @cambridgebrc.bsky.social and the genetic powerhouse of the @sangerinstitute.bsky.social?

submitted 27 days ago • 1 comment

The advert is officially live and you can apply online here: tinyurl.com/yd5bsvfb

submitted 28 days ago • 2 comments

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

submitted 28 days ago • 6 comments

I'm happy to announce a postdoctoral position is available in my lab. We have lots of great data to analyze with respect to transposons & epigenetics and cool biological questions to answer. Please reskeet and share.

submitted 58 days ago • 3 comments

Why does a congressionally chartered, quasi-independent, nonprofit learned society give two licks about what the executive branch thinks? Defeatist. www.statnews.com/2025/02/20/n...

submitted 28 days ago • 0 comments

Calling all final-year PhD students in human genetics - reminder that the deadline for the Leena Peltonen School closes 7 March. Fantastic opportunity for great discussions with faculty, journal editors and other students from across the globe, and for finding postdoc mentors!

submitted 29 days ago • 0 comments

I argued yesterday with both a head of a law department who'd written a book on AI accountability and a young PhD student, neither of whom really understood how or when to use generative AI. Please consider this a draft and give me feedback or other links. joanna-bryson.blogspot.com/2025/02/gene...

submitted 30 days ago • 13 comments

Wow. This is sooo good. Echoing @urbanevol.bsky.social this user’s manual for Ne should be required reading for popgen and conservation genetics folks. onlinelibrary.wiley.com/doi/10.1111/...

submitted 32 days ago • 1 comment

Wild name for a journal spamming my inbox: "Prevention and Treatment of Natural Disasters".

submitted 31 days ago • 0 comments

So…you want more flavours? Sumstats for the PGC MDD2025 meta-analysis now also available as daner and GWAS-SSF, to ease the way in getting them hooked into your analyses. (GWAS-VCF next? 👀) figshare.com/articles/dat...

submitted 32 days ago • 0 comments

submitted 41 days ago • 0 comments

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

submitted 45 days ago • 2 comments

Censor CDC scientists and ask them to withdraw papers from medical journals? This is not how it works, Mr President. Our response @bmj.com on the Trump Executive Order and his "forbidden words" www.bmj.com/content/388/...

submitted 45 days ago • 73 comments

We have two new PDRA positions for folks interested in working on the intersection of stats gen and neurodevelopmental research. Will be based in Cambridge, working closely with @hilarycmartin.bsky.social. Funded until Jan 2027. Deadline: 16 February. here:https://www.jobs.cam.ac.uk/job/50147/

submitted 49 days ago • 0 comments

Report-Negative-Log10-P* Crew checking in. *I'm actually guilty of not doing this.

submitted 49 days ago • 0 comments

🌟 Our new website is live! 🌟 It's designed to provide information and resources for mental health researchers and the wider community. You'll find: 👉Why we need the MHP 👉More about our research Hubs 👉How to get involved #MentalHealthResearch 🔗

submitted 109 days ago • 0 comments

You might forget how much you drink… but your body remembers. Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!) clinicalepigeneticsjournal.biomedcentral.com/articles/10....

submitted 53 days ago • 1 comment

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

submitted 55 days ago • 6 comments

impressive, superhelpful review listing 100s tools for GWAS analysis, with important focus on summary data interpretation biodatamining.biomedcentral.com/articles/10....

submitted 57 days ago • 0 comments

New insight from the PGC #GWAS: Genetic differences in bipolar disorder vary across clinical, community-based, and self-report samples, mainly driven by different prevalences of bipolar subtypes (BDI vs. BDII). Data-gathering strategies matter. 🧬 go.nature.com/3PJhi3W

submitted 57 days ago • 0 comments

1/A fascinating figure that reveals so much about both genetics and clinical psychiatry from a great new #bipolar #genetics paper out in @nature.com www.nature.com/articles/s41...

submitted 58 days ago • 1 comment

We had an amazing time filming yesterday with our incredible volunteers, team, and researchers, filmed by the talented Helios media team! We discussed the importance of young people being involved in research!👩‍🔬🧑‍🔬 We are looking forward to sharing the videos with you soon! 🥳

submitted 58 days ago • 1 comment

Celebrating 100 years of the Pauli exclusion principle www.chemistryworld.com/opinion/cele...

submitted 59 days ago • 0 comments

I discovered my new superpower. As a reviewer I am calling for an end to p values set to 0 (or 1e-300 or 1e-308). If you're fortunate enough to have extreme p-values, report the -log10(p). Who's with me?

submitted 60 days ago • 2 comments

📢 Quantgen friends: We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁 Check out our latest program and apply now! www.grc.org/quantitative...

submitted 60 days ago • 0 comments

We're looking for a talented statistical geneticist to come work with us! www.23andme.com/careers/jobs...

submitted 64 days ago • 0 comments

The Dean Kissick dustup 🧵

submitted 106 days ago • 1 comment

We are part of the @circadianmhnetw.bsky.social which has just launched a study on mental health and body clocks, with public-designed questions on topics you want more research on! Over 12 and in the UK? Help us find the most important ones to you🥰: edinburgh.eu.qualtrics.com/jfe/form/SV_...

submitted 65 days ago • 0 comments

3.1 deca-analysts, 3.78 hecto-scientists, 5.05 mega-participants.

submitted 66 days ago • 1 comment

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

submitted 66 days ago • 4 comments