metastasisresearch.bsky.social
The Metastasis Research Society (MRS) is dedicated to supporting progressive metastatic cancer research with the goal of improving treatments and patient lives.
http://www.metastasis-research.org
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10/ Dr. Lucotti recently published her postdoctoral work on Extracellular vesicles driving lung metastasis through thrombosis in @cellpress.bsky.social.
Read more on this novel and exciting work here π www.cell.com/cell/abstrac...
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9/ How do you envision the ECLC evolving in the near future?
"The future is collaboration, not competition. I envision the ECLC becoming more interdisciplinary, involving diverse perspectives to promote patient health and quality of life."
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8/ In your opinion, what are the biggest obstacles for early career researchers in academia?
"Early career researchers face hardships like fair compensation, workload protections, and immigration rights. I hope that, by offering a collaborative space, the ECLC can help address these issues."
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7/ What do you consider the ECLC's most impactful contribution to early career researchers' development?
"I believe that by organizing regular events, the ECLC offers a platform for connection and collaboration, which hopefully positively impacts research and career success."
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6/...that will bring together senior MRS members with early career investigators to navigate the world of metastasis research and career building. We are also organizing monthly webinars as well as the 2nd Annual ECLC Virtual Meeting (November 2025)."
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5/ How are you working to strengthen the early career researcher community during your tenure?
"I have only been chair for a few months, but together with the amazing ECLC team we are working to implement a new MRS Mentorship program...
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4/...In addition to the amazing activities that the ECLC was already doing before I assumed the role of chair, we are now actively focusing on expanding the early career MRS community and offering financial support for conference attendance via travel bursaries."
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3/ What was your vision for the ECLC when you became chair?
"I become ECLC chair after the 2024 MRS Congress in London. The camaraderie and collaboration within the society are unparalleled and motivated me to reach out to as many ECRs as possible to get involved with the MRS.
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2/ Could you introduce yourself and describe your research?
"I am an instructor at the Department of Pediatrics at Weill Cornell Medicine and my research focuses on the crosstalk between disseminating cells and their microenvironment, particularly platelets, during cancer progression."
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Thanks for flagging that. We've updated the post π
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Done βΊοΈ - If you're not already a member of the society, please consider joining (metastasis-research.org)
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π«Ά
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Done! If you're not already a member, you should consider joining the society (metastasis-research.org)
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Done π
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Added! If you're not already a member, you should consider joining the society (metastasis-research.org)
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Added! If you're not already a member, you should consider joining the society (metastasis-research.org)
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Added! If you're not already a member, you should consider joining the society (metastasis-research.org)
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Done βΊοΈ
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Added! βΊοΈ
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Added! If you're not already a member, you should consider joining the society (metastasis-research.org)
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Added βΊοΈ
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Added βΊοΈ
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Done π
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5/What were your goals as MRS president? π©πΏβπ¬π¨π½βπ¬π©π»βπ¬
To make MRS more welcoming to scientists and clinicians interested in metastasis research, promote junior researchers, enhance ties with patient advocacy groups such as @metavivor and @SusanGKomen, and strengthen our finances.
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4/...My favorite project is our study of Metadherin (MTDH) which is a classic example of cancer fitness genes and ideal therapeutic target to prevent or reduce metastatic cancers.
www.nature.com/articles/s43...
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3/What is your research focus area? π§¬π¬
Our research focuses on tumor cell-intrinsic mechanism (cancer fitness genes) and stromal elements (stromal niche) that relieve the stresses tumor cells encounter during tumor progression and metastasis...
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2/When did you first get involved with the MRS? π
In 2004, when transitioning from my postdoc at MSKCC to my faculty position at Princeton University, Danny Welch invited me to give a talk at the 10th MRS meeting in Genoa, Italy. I have been an active MRS member ever since.
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7/Epigenetic states define disseminated tumor cell (DTC) fate. In this study, the authors find that hypomethylated DTCs respond to WNT ligands, extravasate and undergo dormancy, while methylated DTCs proliferate intravascularly.
@hellmutaugustin.bsky.social
www.nature.com/articles/s43...
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6/Timing of pancreas cancer metastasis. By profiling patient samples, the authors reveal immune remodeling in the pre-metastatic liver and propose liver sampling to determine pancreas cancer metastatic propensity.
David Lyden Weill Cornell
www.nature.com/articles/s41...
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5/Sex and age in metastasis. In this study, the authors find that aged, male fibroblasts intrinsically downregulate EZH2 resulting in elevated BMP2 secretion which drives a highly invasive and therapy-resistant melanoma.
Yash Chhabra @ashi-w.bsky.social
www.cell.com/cell/abstrac...
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4/Astrocyte-mediated upregulation of CDK5 in breast cancer brain metastases drives immune evasion! The authors find that the CDK5 inhibitor roscovitine antagonizes this pathway for immune-eradication of brain mets!
Dihua Yu @mdanderson.bsky.social
www.nature.com/articles/s41...
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3/Chronic stress drives metastasis! Here the authors reveal that exposure to chronic stress results in neutrophil-mediated remodeling of the tumor microenvironment through glucocorticoids for metastasis!
Xueyan He @megeblad.bsky.social
www.cell.com/cancer-cell/...
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2/ The relative scarcity of interactions between dormant disseminated tumor cells (DTC) and antigen specific T-cells explains immune evasion for metastasis! The authors reveal immune-strategies to overcome this for DTC eradication.
Cyrus Ghajar @fredhutch.bsky.social
www.cell.com/cancer-cell/...
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7/Uncover the immune landscape of metastatic niches. This study maps single-cell profiles, identifying TREM2+ regulatory macrophages at invasive margins as drivers of immune evasion.
Ido Yofe, Ido Amit
pubmed.ncbi.nlm.nih.gov/37756565/
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6/Macrophages in the lungs suppress breast cancer metastasis. This study shows alveolar macrophages induce metastatic dormancy by TGF-Ξ²2 signaling, offering new therapeutic insights.
Erica Dalla @micpapanicolaou.bsky.social @miriammerad.bsky.social Julio Aguirre-Ghiso
www.cell.com/cell/abstrac...
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5/Immune dynamics in metastasis. This study maps immune profiles in breast cancer metastatic niche formation, revealing key inflammatory programs, NK cell regulation, & anti-metastatic pathways.
@cmcginnis.bsky.social @jwinkler.bsky.social, Ansu Satpathy
www.cell.com/cancer-cell/...
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4/Delve into the role of vasculature in brain metastases. This study reveals immune-regulatory vascular subtypes in metastatic sites using single-cell RNA-seq & identifies CD276 as a potential target.
Leire Bejarano, @johannajoyce.bsky.social
www.cell.com/cancer-cell/...
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3/Explore how breast cancer cells colonize the brain in this study on triple-negative & HER2+ brain metastases. Unique tumor architectures & microenvironment interactions reveal new mechanisms of brain metastasis.
Joan MassaguΓ©, Siting Gan @mskcancercenter.bsky.social
www.cell.com/cancer-cell/...
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2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes.
@karunamdphd.bsky.social @mskcancercenter.bsky.social
www.nature.com/articles/s41...