msuskiewicz.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

A small-molecule STING agonist is conjugated to a nanobody that binds to serum albumins to increase tumor accumulation and augment antitumor immunity www.nature.com/articles/s41... www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation @cp-immunity.bsky.social www.cell.com/immunity/ful...

submitted 3 days ago • 0 comments

🧬 New from crystal structures from our lab in EMBO Journal! We reveal how the FANCM enzyme, an emerging therapeutic target it cancer, has evolved to specifically recognise branched DNA and activate the Fanconi anaemia pathway of DNA repair. doi.org/10.1038/s443... 🧵👇

submitted 13 days ago • 2 comments

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

submitted 6 days ago • 3 comments

🎉 New paper out in Science! In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer. Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social

submitted 15 days ago • 1 comment

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

submitted 8 days ago • 10 comments

A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

submitted 9 days ago • 0 comments

Congratulations @tbharat-lab.bsky.social !

submitted 9 days ago • 1 comment

ICYMI: New online: Remote on–off switching of protein activity by intrinsically disordered region

submitted 9 days ago • 0 comments

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

submitted 10 days ago • 0 comments

Excited to share that my work in the @aaronwhiteley.bsky.social lab describing chaperone-mediated phage sensing by a bacterial NLR-related protein is out in @plosbiology.org!

submitted 10 days ago • 1 comment

If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!

submitted 10 days ago • 0 comments

My former lab at the University of Oxford is looking for a postdoc to study ADP-ribosylation and ubiquitination signalling in DNA damage using biochemistry and structural biology. my.corehr.com/pls/uoxrecru... Informal inquiries can be sent to Prof Ivan Ahel via email: [email protected].

submitted 10 days ago • 0 comments

Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.

submitted 11 days ago • 0 comments

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

submitted 11 days ago • 0 comments

A potentially very useful tool to assess Cys ligandability on proteins www.sciencedirect.com/science/arti...

submitted 11 days ago • 0 comments

Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice www.nature.com/articles/s41... @natmicrobiol.nature.com

submitted 11 days ago • 0 comments

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening www.nature.com/articles/s41...

submitted 11 days ago • 0 comments

PUPS - prediction of unseen proteins' subcellular localization - uses machine learning models to predict the localization of unseen proteins in unseen cell lines from sequence and cellular images. www.nature.com/articles/s41...

submitted 32 days ago • 0 comments

🚀 Excited to release BoltzDesign1! ✨ Now with LogMD-based trajectory visualization. 🔗 Demo: rcsb.ai/ff9c2b1ee8 Feedback & collabs welcome! 🙌 🔗: GitHub: github.com/yehlincho/Bo... 🔗: Colab: colab.research.google.com/github/yehli... @sokrypton.org @martinpacesa.bsky.social

submitted 12 days ago • 1 comment

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

submitted 18 days ago • 0 comments

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1 www.nature.com/articles/s41...

submitted 14 days ago • 10 comments

Structure determination of stubborn membrane proteins by de novo design of huge, cryo-EMable soluble domains www.biorxiv.org/content/10.1...

submitted 15 days ago • 1 comment

BRAF oncogenic mutants evade autoinhibition through a common mechanism @science.org www.science.org/doi/10.1126/...

submitted 16 days ago • 0 comments

Super cool work on the function of intrinsically disordered regions in regulating transcription factor DNA binding.

submitted 17 days ago • 1 comment

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

submitted 17 days ago • 2 comments

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

submitted 19 days ago • 1 comment

For the DNA polymerase θ afficionados: www.nature.com/articles/s41... This N&Vs by Sylvie Doublié nicely contextualises the progress imparted by this NSMB paper www.nature.com/articles/s41... by ‪@landerlab.bsky.social and this NatComms paper www.nature.com/articles/s41... by the Chen/Pomerantz labs

submitted 18 days ago • 0 comments

Are there spatial restrictions in NLRP3 #inflammasome activation? I am super excited to share our new study spearheaded by amazing @elvirab.bsky.social www.nature.com/articles/s41...

submitted 18 days ago • 0 comments

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

submitted 19 days ago • 12 comments

A protein-DNA surface hydrogel mechanically protects the cell nucleus https://www.biorxiv.org/content/10.1101/2025.05.21.655270v1

submitted 19 days ago • 0 comments

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

submitted 22 days ago • 1 comment

Happy that my work on RNF213 has been published as a part of doi.org/10.1038/s414...! Many thanks to all the groups involved: @clausenlab.bsky.social @e3chembio.bsky.social @fletcherlab.bsky.social Have a look at the summary from Fletcher lab for an insider perspective of the paper's history:

submitted 23 days ago • 0 comments

A very interesting new paper from the Vertegaal lab on noncovalent SUMO binders that do not depend on the canonical SIM-binding groove. Identifies certain WD40 repeat domains as SUMO binders.

submitted 19 days ago • 0 comments

Super cool story on branched UB chain formation. Congrats Sam!

submitted 19 days ago • 1 comment

Come work with me an Sarah and become a part of DDLS danaher.wd1.myworkdayjobs.com/CytivaJobsPP...

submitted 19 days ago • 1 comment

Looking forward to attending, for the first time in my life, the congress of the Polish Biochemical Society, held this year in Poznań on 17-20 September.

submitted 20 days ago • 0 comments

A few years back we discovered a novel dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub): pubmed.ncbi.nlm.nih.gov/36197986/

submitted 22 days ago • 1 comment

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

submitted 23 days ago • 1 comment

Elated to share that this story about an unexpected and important finding is now published @pnas.org www.pnas.org/doi/10.1073/... These findings have laid a strong foundation for us to now identify proteins critical for cell proliferation at 37°C in a human fungal pathogen.

submitted 21 days ago • 1 comment

ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription

submitted 21 days ago • 0 comments

Our review on #AlphaFold focussing on prediction classes beyond simple protein monomers (PPIs, conformational changes, protein-ligand complexes, etc) royalsocietypublishing.org/doi/10.1098/...

submitted 53 days ago • 1 comment

This is just an excellent preprint by Rasmus Jensen and colleagues from Julia Mahamid's lab @embl.org - a tour de force of Cryogenic electron tomography to do in cell structural biology in which they discover a new complex and solve its structure and function! www.biorxiv.org/content/10.1...

submitted 23 days ago • 2 comments

Happy to share a new little paper from our team - by @origichals.bsky.social et al. It describes a strategy to make SUMO1 more crystallisable by fusing it with a helper domain. Check out the nice ITC showing it still binds to SIM motifs. We are now working on co-crystallisation with SIM peptides.

submitted 22 days ago • 1 comment